Figure 3.

Schematic representation of the genes regulated by Ashwagandha extract in JAK-STAT signaling pathway. The genes highlighted with an asterisk (*) are significantly regulated by Ashwagandha and are important in the regulation of cell proliferation, regulation of apoptosis and immunomodulation.

Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-proliferative Effects of Dietary Flavonoid--'Ashwagandha' in Prostate Cancer Cells

Evid Based Complement Alternat Med. 2010 June;7(2):177-187.
Figure 1.

Ashwagandha treatment inhibits cell proliferation in PC-3 cells. Results show that treatment with Ashwagandha significantly decreased cell proliferation. Data are the mean ± SD of three separate experiments done in triplicate. Statistical significance was determined by ANOVA.

Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-proliferative Effects of Dietary Flavonoid--'Ashwagandha' in Prostate Cancer Cells

Evid Based Complement Alternat Med. 2010 June;7(2):177-187.
Figure 5.

Ashwagandha treatment significantly modulates protein expression in PC-3 cells. Graphical representation of quantitative changes in protein expression by Western blot analysis. Data are the mean ± SD of three separate experiments done in triplicate. Statistical significance was determined by ANOVA.

Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-proliferative Effects of Dietary Flavonoid--'Ashwagandha' in Prostate Cancer Cells

Evid Based Complement Alternat Med. 2010 June;7(2):177-187.
Figure 6Recovery of neuronal cell differentiation markers in scopolamine-treated cells in response to Ashwagandha i-Extract and withanone treatment.

Level of MAP2, NF-H, GAP43 and PSD-95 expression in IMR32 neuroblastoma cells treated with either scopolamine or scopolamine and i-Extract/withaferin A/withanone as described in material and methods. Levels of expression as detected by western blotting (A) and immunocytostaining (B) are shown. Quantitation was performed as described for Figure 5.

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells

PLoS One. 2011;6(11):e27265.

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Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. [Altern Med Rev. 2000]
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
Mishra LC, Singh BB, Dagenais S. Altern Med Rev. 2000 Aug; 5(4):334-46.
Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. [Cent Nerv Syst Agents Med Chem...]
Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha.
Ven Murthy MR, Ranjekar PK, Ramassamy C, Deshpande M. Cent Nerv Syst Agents Med Chem. 2010 Sep 1; 10(3):238-46.
Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. [Int J Ayurveda Res. 2010]
Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults.
Sandhu JS, Shah B, Shenoy S, Chauhan S, Lavekar GS, Padhi MM. Int J Ayurveda Res. 2010 Jul; 1(3):144-9.

87 free full-text articles in PubMed Central

De Novo Assembly, Functional Annotation and Comparative Analysis of Withania somnifera Leaf and Root Transcriptomes to Identify Putative Genes Involved in the Withanolides Biosynthesis. [PLoS One. 2013]
De Novo Assembly, Functional Annotation and Comparative Analysis of Withania somnifera Leaf and Root Transcriptomes to Identify Putative Genes Involved in the Withanolides Biosynthesis.
Gupta P, Goel R, Pathak S, Srivastava A, Singh SP, Sangwan RS, Asif MH, Trivedi PK. PLoS One. 2013; 8(5):e62714. Epub 2013 May 8.
Overexpression of WsSGTL1 Gene of Withania somnifera Enhances Salt Tolerance, Heat Tolerance and Cold Acclimation Ability in Transgenic Arabidopsis Plants. [PLoS One. 2013]
Overexpression of WsSGTL1 Gene of Withania somnifera Enhances Salt Tolerance, Heat Tolerance and Cold Acclimation Ability in Transgenic Arabidopsis Plants.
Mishra MK, Chaturvedi P, Singh R, Singh G, Sharma LK, Pandey V, Kumari N, Misra P. PLoS One. 2013; 8(4):e63064. Epub 2013 Apr 30.
Identification of antifungal principle in the solvent extract of an endophytic fungus Chaetomium globosum from Withania somnifera. [Springerplus. 2013]
Identification of antifungal principle in the solvent extract of an endophytic fungus Chaetomium globosum from Withania somnifera.
Kumar S, Kaushik N, Proksch P. Springerplus. 2013 Dec; 2(1):37. Epub 2013 Feb 6.