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Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk.
Kulminski AM, Philipp I, Shu L, Culminskaya I. Kulminski AM, et al. Neurobiol Aging. 2022 Feb;110:122-131. doi: 10.1016/j.neurobiolaging.2021.09.009. Epub 2021 Sep 15. Neurobiol Aging. 2022. PMID: 34625307 Free PMC article.
Despite advances, the roles of genetic variants from the APOE-harboring 19q13.32 region in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach to gain insights into a more homogeneous genetic architecture of AD in this region. …
Despite advances, the roles of genetic variants from the APOE-harboring 19q13.32 region in Alzheimer's disease (AD) rem …
Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait association analysis.
Guo P, Gong W, Li Y, Liu L, Yan R, Wang Y, Zhang Y, Yuan Z. Guo P, et al. BMC Med. 2022 Jun 22;20(1):214. doi: 10.1186/s12916-022-02404-2. BMC Med. 2022. PMID: 35729600 Free PMC article.
In addition, the genetic determinants underlying LBD and the shared genetic etiology with Alzheimer's disease (AD) and Parkinson's disease (PD) remain poorly understood. ...We identified 13 significant loci for LBD, including 5 previously reported loci …
In addition, the genetic determinants underlying LBD and the shared genetic etiology with Alzheimer's disease (AD) and …
Functional regulatory variants implicate distinct transcriptional networks in dementia.
Cooper YA, Teyssier N, Dräger NM, Guo Q, Davis JE, Sattler SM, Yang Z, Patel A, Wu S, Kosuri S, Coppola G, Kampmann M, Geschwind DH. Cooper YA, et al. Science. 2022 Aug 19;377(6608):eabi8654. doi: 10.1126/science.abi8654. Epub 2022 Aug 19. Science. 2022. PMID: 35981026
In this study, we used massively parallel reporter assays to screen 5706 variants identified from genome-wide association studies for both Alzheimer's disease (AD) and progressive supranuclear palsy (PSP), identifying 320 functional regulatory variants (frVar …
In this study, we used massively parallel reporter assays to screen 5706 variants identified from genome-wide association studies for both …
Identification of highly reliable risk genes for Alzheimer's disease through joint-tissue integrative analysis.
Wang YH, Luo PP, Geng AY, Li X, Liu TH, He YJ, Huang L, Tang YQ. Wang YH, et al. Front Aging Neurosci. 2023 Jun 21;15:1183119. doi: 10.3389/fnagi.2023.1183119. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37416324 Free PMC article.
Numerous genetic variants associated with Alzheimer's disease (AD) have been identified through genome-wide association studies (GWAS), but their interpretation is hindered by the strong linkage disequilibrium (LD) among the variants, making it difficult to i …
Numerous genetic variants associated with Alzheimer's disease (AD) have been identified through genome-wide association …
Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis.
Zhou Q, Zhao F, Lv ZP, Zheng CG, Zheng WD, Sun L, Wang NN, Pang S, de Andrade FM, Fu M, He XH, Hui J, Jiang W, Yang CY, Shi XH, Zhu XQ, Pang GF, Yang YG, Xie HQ, Zhang WD, Hu CY, Yang Z. Zhou Q, et al. PLoS One. 2014 Jan 31;9(1):e87017. doi: 10.1371/journal.pone.0087017. eCollection 2014. PLoS One. 2014. PMID: 24498013 Free PMC article.
BACKGROUND: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer's disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk fact …
BACKGROUND: Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer …
Associations of the APOE epsilon2 and epsilon4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers.
Kulminski AM, Jain-Washburn E, Loiko E, Loika Y, Feng F, Culminskaya I; Alzheimer’s Disease Neuroimaging Initiative. Kulminski AM, et al. Aging (Albany NY). 2022 Nov 17;14(24):9782-9804. doi: 10.18632/aging.204384. Epub 2022 Nov 17. Aging (Albany NY). 2022. PMID: 36399096 Free PMC article.
Capturing the genetic architecture of Alzheimer's disease (AD) is challenging because of the complex interplay of genetic and non-genetic factors in its etiology. ...Modulation of the effect of the epsilon4 alleles by TOMM40 and APOC1 variants indicate …
Capturing the genetic architecture of Alzheimer's disease (AD) is challenging because of the complex interplay of genet …
Genetic influences on Alzheimer's disease: evidence of interactions between the genes APOE, APOC1 and ACE in a sample population from the South of Brazil.
Lucatelli JF, Barros AC, Silva VK, Machado Fda S, Constantin PC, Dias AA, Hutz MH, de Andrade FM. Lucatelli JF, et al. Neurochem Res. 2011 Aug;36(8):1533-9. doi: 10.1007/s11064-011-0481-7. Epub 2011 May 1. Neurochem Res. 2011. PMID: 21533863
Alzheimer's disease is a complex neurodegenerative disorder. Several genes have been suggested as Alzheimer's susceptibility factors, the apolipoprotein E (APOE) gene being an established susceptibility gene and the genes coding angiotensin-conv …
Alzheimer's disease is a complex neurodegenerative disorder. Several genes have been suggested as Alzheimer's …
Ranking the risk factors for Alzheimer's disease; findings from the UK Biobank study.
Allwright M, Mundell HD, McCorkindale AN, Lindley RI, Austin PJ, Guennewig B, Sutherland GT. Allwright M, et al. Aging Brain. 2023 Jun 17;3:100081. doi: 10.1016/j.nbas.2023.100081. eCollection 2023. Aging Brain. 2023. PMID: 37384134 Free PMC article.
BACKGROUND: The cause of the most common form of dementia, sporadic Alzheimer's disease (AD), remains unknown. This may reflect insufficiently powered studies to date for this multi-factorial disorder. ...CONCLUSIONS: Possession of the APOE4 allele was confir …
BACKGROUND: The cause of the most common form of dementia, sporadic Alzheimer's disease (AD), remains unknown. This may …
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
Zhou Q, Peng D, Yuan X, Lv Z, Pang S, Jiang W, Yang C, Shi X, Pang G, Yang Y, Xie H, Zhang W, Hu C, Yang Z. Zhou Q, et al. Neural Regen Res. 2014 Mar 15;9(6):653-60. doi: 10.4103/1673-5374.130117. Neural Regen Res. 2014. PMID: 25206869 Free PMC article.
Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in …
Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein ( …
Biothiols and oxidative stress markers and polymorphisms of TOMM40 and APOC1 genes in Alzheimer's disease patients.
Prendecki M, Florczak-Wyspianska J, Kowalska M, Ilkowski J, Grzelak T, Bialas K, Wiszniewska M, Kozubski W, Dorszewska J. Prendecki M, et al. Oncotarget. 2018 Oct 16;9(81):35207-35225. doi: 10.18632/oncotarget.26184. eCollection 2018 Oct 16. Oncotarget. 2018. PMID: 30443289 Free PMC article.
Alzheimer's disease (AD) is a progressive disease, with frequently observed improper biothiols turnover, homocysteine (Hcy) and glutathione (GSH). ...The presence of unfavorable alleles, e.g., in APOE cluster, TOMM40 or APOC1 is known to facilit …
Alzheimer's disease (AD) is a progressive disease, with frequently observed improper biothiols turnover, homocys …
78 results