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Posttraumatic Stress Disorder: Evaluation and Treatment.
Sartor Z, Kelley L, Laschober R. Sartor Z, et al. Am Fam Physician. 2023 Mar;107(3):273-281. Am Fam Physician. 2023. PMID: 36920821
First-line treatment of PTSD involves psychotherapy, such as trauma-focused cognitive behavior therapy. Pharmacotherapy is useful for patients who have residual symptoms after psychotherapy or are unable or unwilling to access psychotherapy. Selective serotonin …
First-line treatment of PTSD involves psychotherapy, such as trauma-focused cognitive behavior therapy. Pharmacotherapy is use …
Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
Skelly MJ, Weiner JL. Skelly MJ, et al. Brain Behav. 2014 Jul;4(4):468-83. doi: 10.1002/brb3.230. Epub 2014 Apr 14. Brain Behav. 2014. PMID: 25161814 Free PMC article.
The purpose of these studies was to examine the long-term effectiveness of pharmacological interventions presumed to decrease norepinephrine signaling on concomitant ethanol self-administration and anxiety-like behavior in adult rats with relatively high levels of antecede …
The purpose of these studies was to examine the long-term effectiveness of pharmacological interventions presumed to decrease norepinephrine …
[Treatment-resistant anxiety disorders: A literature review of drug therapy strategies].
Ammar G, Naja WJ, Pelissolo A. Ammar G, et al. Encephale. 2015 Jun;41(3):260-5. doi: 10.1016/j.encep.2013.11.002. Epub 2014 Nov 14. Encephale. 2015. PMID: 25439852 Review. French.
Serotonin reuptake inhibitors (SRI) and serotonin and norepinephrine reuptake inhibitors (SNRI) have demonstrated a rather robust efficacy for the treatment of most of anxiety disorders. ...Other trials showed some efficacy of anticonvulsants (lamotrigine, to …
Serotonin reuptake inhibitors (SRI) and serotonin and norepinephrine reuptake inhibitors (SNRI) have demonstrated a rather rob …
Treatment of posttraumatic stress disorder: Focus on pharmacotherapy.
Ehret M. Ehret M. Ment Health Clin. 2019 Nov 27;9(6):373-382. doi: 10.9740/mhc.2019.11.373. eCollection 2019 Nov. Ment Health Clin. 2019. PMID: 31857933 Free PMC article.
Current clinical practice guidelines for the treatment of posttraumatic stress disorder offer varying recommendations regarding the use of pharmacotherapy. Many direct head-to-head comparisons of pharmacotherapy are lacking, and recommendations are based on meta-ana …
Current clinical practice guidelines for the treatment of posttraumatic stress disorder offer varying recommendations regarding the use of …
Pharmacotherapy for disordered sleep in post-traumatic stress disorder: a systematic review.
van Liempt S, Vermetten E, Geuze E, Westenberg HG. van Liempt S, et al. Int Clin Psychopharmacol. 2006 Jul;21(4):193-202. doi: 10.1097/00004850-200607000-00001. Int Clin Psychopharmacol. 2006. PMID: 16687990 Review.
We performed a Medline, EMBASE and Cochrane Library Indexed search, using the keywords: PTSD, pharmacotherapy, therapy, sleep, nightmares, insomnia and review. From this database, English-language, human subject, data driven papers published after 1980 were selected …
We performed a Medline, EMBASE and Cochrane Library Indexed search, using the keywords: PTSD, pharmacotherapy, therapy, sleep, …
Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin.
Azevedo H, Ferreira M, Mascarello A, Osten P, Guimarães CRW. Azevedo H, et al. Neurobiol Stress. 2020 May 13;13:100226. doi: 10.1016/j.ynstr.2020.100226. eCollection 2020 Nov. Neurobiol Stress. 2020. PMID: 32478146 Free PMC article.
Here, we applied c-fos mapping to produce a comprehensive view of stress-activated brain regions in mice exposed to SPS alone or to SPS after oral pretreatment with the serotonin-noradrenaline receptor dual modulator ACH-000029 or the alpha1-adrenergic blocker prazosin …
Here, we applied c-fos mapping to produce a comprehensive view of stress-activated brain regions in mice exposed to SPS alone or to SPS afte …
The serotonergic and alpha-1 adrenergic receptor modulator ACH-000029 ameliorates anxiety-like behavior in a post-traumatic stress disorder model.
Azevedo H, Ferreira M, Mascarello A, Osten P, Werneck Guimarães CR. Azevedo H, et al. Neuropharmacology. 2020 Mar 1;164:107912. doi: 10.1016/j.neuropharm.2019.107912. Epub 2019 Dec 13. Neuropharmacology. 2020. PMID: 31843397 Free article.
Here, we investigated the potential of ACH-000029 to prevent anxiety-like behavior in the single prolonged stress (SPS) PTSD model. ...Interestingly, treatment with ACH-000029 but not with prazosin ameliorated the SPS-induced sociability impairment and anxiety …
Here, we investigated the potential of ACH-000029 to prevent anxiety-like behavior in the single prolonged stress (SPS) PTSD model. . …
Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review.
Berger W, Mendlowicz MV, Marques-Portella C, Kinrys G, Fontenelle LF, Marmar CR, Figueira I. Berger W, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):169-80. doi: 10.1016/j.pnpbp.2008.12.004. Epub 2008 Dec 24. Prog Neuropsychopharmacol Biol Psychiatry. 2009. PMID: 19141307 Free PMC article. Review.
The selective serotonin reuptake inhibitors (SSRIs) are considered the first-line pharmacological treatment for PTSD. ...Prazosin, an adrenergic-inhibiting agent, is a promising alternative for cases of PTSD where nightmares and insomnia are prominent symptoms. ...
The selective serotonin reuptake inhibitors (SSRIs) are considered the first-line pharmacological treatment for PTSD. ...Prazosin …
Antidepressant- and anxiolytic-like actions of Cajanus cajan seed extract mediated through monoaminergic, nitric oxide-cyclic GMP and GABAergic pathways.
Olubodun-Obadun TG, Ishola IO, Adesokan TP, Anih BO, Adeyemi OO. Olubodun-Obadun TG, et al. J Ethnopharmacol. 2023 Apr 24;306:116142. doi: 10.1016/j.jep.2023.116142. Epub 2023 Jan 11. J Ethnopharmacol. 2023. PMID: 36638856 Free article.

In anxiety model, CC produced significant (p < 0.05) increase in open arms exploration and head dipping behavior which was reversed by flumazenil (benzodiazepine receptor antagonist) in the EPM. ...Moreso, presence of flavonoids with significant binding energies with mo

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In anxiety model, CC produced significant (p < 0.05) increase in open arms exploration and head dipping behavior which was reverse

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The effects of the co-administration of the alpha1-adrenoreceptor antagonist prazosin on the anxiolytic effect of citalopram in conditioned fear stress in the rat.
Takamura N, Masuda T, Inoue T, Nakagawa S, Koyama T. Takamura N, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):107-11. doi: 10.1016/j.pnpbp.2012.05.017. Epub 2012 May 30. Prog Neuropsychopharmacol Biol Psychiatry. 2012. PMID: 22658980
Several studies have shown that the alpha1-adrenoreceptor is involved in controlling extracellular serotonin levels. The administration of the alpha1-adrenoreceptor antagonist prazosin was shown to decrease extracellular serotonin levels in the hippocampus, t …
Several studies have shown that the alpha1-adrenoreceptor is involved in controlling extracellular serotonin levels. The administrati …
13 results