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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1984 5
1985 5
1986 4
1987 6
1988 17
1989 21
1990 35
1991 35
1992 36
1993 40
1994 34
1995 41
1996 49
1997 31
1998 26
1999 33
2000 29
2001 18
2002 21
2003 12
2004 21
2005 14
2006 28
2007 19
2008 19
2009 14
2010 9
2011 17
2012 11
2013 10
2014 10
2015 13
2016 9
2017 15
2018 10
2019 10
2020 11
2021 7
2022 6
2023 4
2024 0

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709 results

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Page 1
The involvement of sigma and phencyclidine receptors in the action of antipsychotic drugs.
Lang A, Vasar E, Soosaar A, Harro J. Lang A, et al. Pharmacol Toxicol. 1992 Aug;71(2):132-8. doi: 10.1111/j.1600-0773.1992.tb00532.x. Pharmacol Toxicol. 1992. PMID: 1332017
An atypical antipsychotic drug clozapine and a selective sigma antagonist BMY 14802 were significantly less effective in the behavioural experiments (against apomorphine, d-amphetamine and MK-801), as well in the radioligand binding studies against 3H-spiperone (dop …
An atypical antipsychotic drug clozapine and a selective sigma antagonist BMY 14802 were significantly less effective in the b …
Inhibition of sigma-1 receptors substantially modulates GABA and glutamate transport in presynaptic nerve terminals.
Pozdnyakova N, Krisanova N, Dudarenko M, Vavers E, Zvejniece L, Dambrova M, Borisova T. Pozdnyakova N, et al. Exp Neurol. 2020 Nov;333:113434. doi: 10.1016/j.expneurol.2020.113434. Epub 2020 Aug 11. Exp Neurol. 2020. PMID: 32795464
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric disorders and are a novel target for the treatment of such disorders. ...NE-100 at doses of 1 and 10 muM increased the initial rate of synaptosomal [(3)H]GABA uptake, whereas 50 an …
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric disorders and are a novel target for the …
Sigma receptors and sigma ligands: background to a pharmacological enigma.
Leonard BE. Leonard BE. Pharmacopsychiatry. 2004 Nov;37 Suppl 3:S166-70. doi: 10.1055/s-2004-832674. Pharmacopsychiatry. 2004. PMID: 15547782 Review.
Although it is now well established that the sigma receptors are distinct from neurotransmitter, neuropeptide and steroid receptors, their precise physiological role, and possible involvement in the pathology of neurological and psychiatric disorders, remains …
Although it is now well established that the sigma receptors are distinct from neurotransmitter, neuropeptide and steroid r …
Evaluation of sigma (sigma) receptors in the antidepressant-like effects of ketamine in vitro and in vivo.
Robson MJ, Elliott M, Seminerio MJ, Matsumoto RR. Robson MJ, et al. Eur Neuropsychopharmacol. 2012 Apr;22(4):308-17. doi: 10.1016/j.euroneuro.2011.08.002. Epub 2011 Sep 10. Eur Neuropsychopharmacol. 2012. PMID: 21911285
Ketamine is an NMDA antagonist and dissociative anesthetic that has been shown to display rapid acting and prolonged antidepressant activity in small-scale human clinical trials. Ketamine also binds to sigma receptors, which are believed to be protein targets for a …
Ketamine is an NMDA antagonist and dissociative anesthetic that has been shown to display rapid acting and prolonged antidepressant activity …
1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.
Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF. Weber E, et al. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8784-8. doi: 10.1073/pnas.83.22.8784. Proc Natl Acad Sci U S A. 1986. PMID: 2877462 Free PMC article.
The biochemical characterization of sigma receptors has been difficult because of the lack of potent and selective ligands. ...These results indicate that [3H]Tol2Gdn is a selective ligand for the sigma-site. Availability of this sigma-receptor probe s …
The biochemical characterization of sigma receptors has been difficult because of the lack of potent and selective ligands. .. …
Receptor mechanisms in antipsychotic drug action: focus on sigma receptors.
Snyder SH, Largent BL. Snyder SH, et al. J Neuropsychiatry Clin Neurosci. 1989 Winter;1(1):7-15. doi: 10.1176/jnp.1.1.7. J Neuropsychiatry Clin Neurosci. 1989. PMID: 2577720 Review.
Some promising "new generation" candidate drugs have shown beneficial effects in schizophrenic patients in early clinical trials. These new agents share a selective, high affinity for sigma receptors, sites where psychotomimetic opiates act. A systematic scre …
Some promising "new generation" candidate drugs have shown beneficial effects in schizophrenic patients in early clinical trials. These new …
Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines.
Palmer CP, Mahen R, Schnell E, Djamgoz MB, Aydar E. Palmer CP, et al. Cancer Res. 2007 Dec 1;67(23):11166-75. doi: 10.1158/0008-5472.CAN-07-1771. Cancer Res. 2007. PMID: 18056441
Cholesterol is critical for liquid-ordered raft formation by serving as a spacer between the hydrocarbon chains of sphingolipids, and alterations in the cholesterol contents of the plasma membrane causes disruption of rafts. The role that sigma receptors play in can …
Cholesterol is critical for liquid-ordered raft formation by serving as a spacer between the hydrocarbon chains of sphingolipids, and altera …
Functional and binding properties of sigma receptors in rat cerebellum.
Gonzalez-Alvear GM, Thompson-Montgomery D, Deben SE, Werling LL. Gonzalez-Alvear GM, et al. J Neurochem. 1995 Dec;65(6):2509-16. doi: 10.1046/j.1471-4159.1995.65062509.x. J Neurochem. 1995. PMID: 7595545
In contrast to findings in the hippocampus, where regulation is via sigma 1 and sigma 2 receptors, sigma-mediated regulation in cerebellum seems to be primarily via sigma 1 receptors. In radioligand binding studies, we find that sigma …
In contrast to findings in the hippocampus, where regulation is via sigma 1 and sigma 2 receptors, sigma-mediate …
Pharmacological comparison of antipsychotic drugs and sigma-antagonists in rodents.
Lang A, Soosaar A, Kõks S, Volke V, Bourin M, Bradwejn J, Vasar E. Lang A, et al. Pharmacol Toxicol. 1994 Sep-Oct;75(3-4):222-7. doi: 10.1111/j.1600-0773.1994.tb00351.x. Pharmacol Toxicol. 1994. PMID: 7800667
By contrast, no correlation was found between the behavioural effects of these drugs and their affinity at dopamine1-5-HT2- and sigma receptors. The rank order of potency among the studied antipsychotic drugs in the behavioural tests and at dopamine2-recep …
By contrast, no correlation was found between the behavioural effects of these drugs and their affinity at dopamine1-5-HT2- and sigma …
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.
Zhang H, Cuevas J. Zhang H, et al. J Neurophysiol. 2002 Jun;87(6):2867-79. doi: 10.1152/jn.2002.87.6.2867. J Neurophysiol. 2002. PMID: 12037190 Free article.
Studies on the expression and cellular function of sigma receptors in autonomic neurons were conducted in neonatal rat intracardiac and superior cervical (SCG) ganglia. ...In addition to depressing peak Ca2+ channel current, sigma receptors altered the …
Studies on the expression and cellular function of sigma receptors in autonomic neurons were conducted in neonatal rat intraca …
709 results