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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 2
1975 2
1976 1
1977 2
1978 2
1979 2
1980 1
1981 1
1982 1
1983 1
1985 1
1986 5
1987 4
1988 6
1989 7
1990 5
1991 8
1992 8
1993 15
1994 33
1995 28
1996 34
1997 26
1998 38
1999 38
2000 39
2001 48
2002 46
2003 70
2004 49
2005 54
2006 55
2007 72
2008 84
2009 50
2010 53
2011 63
2012 42
2013 39
2014 32
2015 27
2016 34
2017 26
2018 23
2019 24
2020 17
2021 19
2022 12
2023 13
2024 4

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1,142 results

Results by year

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Page 1
Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis.
Siafis S, Wu H, Wang D, Burschinski A, Nomura N, Takeuchi H, Schneider-Thoma J, Davis JM, Leucht S. Siafis S, et al. Mol Psychiatry. 2023 Aug;28(8):3267-3277. doi: 10.1038/s41380-023-02203-y. Epub 2023 Aug 3. Mol Psychiatry. 2023. PMID: 37537284 Free PMC article.
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but their dose-effects are unclear. ...We searched multiple electronic databases up to 20.02.2023 for fixed-dose studies investigating 16 second-generation antipsychotics and halo …
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but their dose-effects are unclear. ...We …
Pharmacological Treatment of Early-Onset Schizophrenia: A Critical Review, Evidence-Based Clinical Guidance and Unmet Needs.
Lopez-Morinigo JD, Leucht S, Arango C. Lopez-Morinigo JD, et al. Pharmacopsychiatry. 2022 Sep;55(5):233-245. doi: 10.1055/a-1854-0185. Epub 2022 Jul 1. Pharmacopsychiatry. 2022. PMID: 35777418 Free PMC article. Review.
Early-onset schizophrenia (EOS) - onset before age 18 - is linked with great disease burden and disability. ...We also evaluated the coverage of these outcomes to identify unmet needs.One systematic review, nine meta-analyses and two umbrella reviews (k=203 trials, N=81,28 …
Early-onset schizophrenia (EOS) - onset before age 18 - is linked with great disease burden and disability. ...We also evaluated the …
Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia.
Barber S, Olotu U, Corsi M, Cipriani A. Barber S, et al. Cochrane Database Syst Rev. 2017 Mar 23;3(3):CD006324. doi: 10.1002/14651858.CD006324.pub3. Cochrane Database Syst Rev. 2017. PMID: 28333365 Free PMC article. Review.
BACKGROUND: Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate blood levels. ...SELECTION CRITERIA: We included only RCTs recruiting people of both sexes, aged 18 years or more, with a diagnosis of trea …
BACKGROUND: Between 40% and 70% of people with treatment-resistant schizophrenia do not respond to clozapine, despite adequate …
Schizophrenia.
Barry SJ, Gaughan TM, Hunter R. Barry SJ, et al. BMJ Clin Evid. 2012 Jun 28;2012:1007. BMJ Clin Evid. 2012. PMID: 23870705 Free PMC article. Review.
METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug treatments for positive, negative, or cognitive symptoms of schizophrenia? What are the effects of drug treatments in people with sc …
METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of drug tr …
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Kane J, Honigfeld G, Singer J, Meltzer H. Kane J, et al. Arch Gen Psychiatry. 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001. Arch Gen Psychiatry. 1988. PMID: 3046553 Clinical Trial.
The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine, an atypical antipsychotic drug, has long been of scientific interest, but its clinical development has been delayed because of an associat …
The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptics is a major challenge. Clozapine, an at …
Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine.
Mesholam-Gately RI, Gibson LE, Seidman LJ, Green AI. Mesholam-Gately RI, et al. Schizophr Res. 2014 May;155(1-3):45-51. doi: 10.1016/j.schres.2014.03.002. Epub 2014 Mar 29. Schizophr Res. 2014. PMID: 24685823
Co-occurring substance use disorders (SUD), including alcohol, are common in schizophrenia (SZ) and are associated with poor outcome. Emerging data suggest that individuals with SZ have a dysfunctional brain reward circuit that may underlie their frequent use of alcohol an …
Co-occurring substance use disorders (SUD), including alcohol, are common in schizophrenia (SZ) and are associated with poor outcome. …
Effectiveness of clozapine, haloperidol and chlorpromazine in schizophrenia during a five-year period.
Ravanic DB, Dejanovic SM, Janjic V, Jovic SD, Milovanovic DR, Jakovljevic V, Pantovic V, Ravanic B, Pantovic M, Pantovic MM. Ravanic DB, et al. Arq Neuropsiquiatr. 2009 Jun;67(2A):195-202. doi: 10.1590/s0004-282x2009000200005. Arq Neuropsiquiatr. 2009. PMID: 19547808 Free article. Clinical Trial.
OBJECTIVE: The aim of our study was to evaluate the effects of low doses of clozapine in flexible regime in comparison with haloperidol and chlorpromazine in long term. ...The patients were allocated to receive haloperidol (105 subjects, dose range 2-15 mg), …
OBJECTIVE: The aim of our study was to evaluate the effects of low doses of clozapine in flexible regime in comparison with halope …
Haloperidol and clozapine block formation of autophagolysosomes in rat primary neurons.
Park J, Chung S, An H, Kim J, Seo J, Kim DH, Yoon SY. Park J, et al. Neuroscience. 2012 May 3;209:64-73. doi: 10.1016/j.neuroscience.2012.02.035. Epub 2012 Feb 24. Neuroscience. 2012. PMID: 22390943
Early intervention and maintenance treatment for schizophrenia patients may prolong the duration of exposure to antipsychotic agents; however, there have been few studies on the neurotoxicity of these agents. ...Together, these results suggest that …
Early intervention and maintenance treatment for schizophrenia patients may prolong the duration of exposure to antipsychotic …
Characterization of antipsychotic utilization before clozapine initiation for individuals with schizophrenia: an innovative visualization of trajectories using French National Health Insurance data.
Laforgue EJ, Istvan M, Chaslerie A, Artarit P, Vallot G, Jolliet P, Grall-Bronnec M, Victorri-Vigneau C. Laforgue EJ, et al. Epidemiol Psychiatr Sci. 2023 Sep 19;32:e59. doi: 10.1017/S2045796023000732. Epidemiol Psychiatr Sci. 2023. PMID: 37723967 Free PMC article.
AIMS: Despite recommendations to initiate clozapine after two unsuccessful trials of antipsychotics, clozapine is underprescribed and initiated too late. The aim of this study was to describe different antipsychotic treatment sequences in the 36 months before …
AIMS: Despite recommendations to initiate clozapine after two unsuccessful trials of antipsychotics, clozapine is underprescri …
Effects of haloperidol and clozapine on synapse-related gene expression in specific brain regions of male rats.
von Wilmsdorff M, Manthey F, Bouvier ML, Staehlin O, Falkai P, Meisenzahl-Lechner E, Schmitt A, Gebicke-Haerter PJ. von Wilmsdorff M, et al. Eur Arch Psychiatry Clin Neurosci. 2018 Sep;268(6):555-563. doi: 10.1007/s00406-018-0872-8. Epub 2018 Feb 5. Eur Arch Psychiatry Clin Neurosci. 2018. PMID: 29404686
We investigated the effects of clozapine and haloperidol, drugs that are widely used in the treatment of schizophrenia, on gene expression in six cortical and subcortical brain regions of adult rats. Drug treatments started at postnatal day 85 and continued o …
We investigated the effects of clozapine and haloperidol, drugs that are widely used in the treatment of schizophrenia, …
1,142 results