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Moderate O(3)/O(2) therapy enhances enzymatic and non-enzymatic antioxidant in brain and cochlear that protects noise-induced hearing loss.
Nasezadeh P, Shahi F, Fridoni M, Seydi E, Izadi M, Salimi A. Nasezadeh P, et al. Free Radic Res. 2017 Oct;51(9-10):828-837. doi: 10.1080/10715762.2017.1381695. Epub 2017 Oct 12. Free Radic Res. 2017. PMID: 29022413
Mitochondrial damage and oxidative stress are known to contribute to the pathogenesis of noise-induced hearing loss (NIHL). In this study, we examined the protective effect of O(2)/O(3) mixture (ozone/oxygen) therapy against mitochondrial induced …
Mitochondrial damage and oxidative stress are known to contribute to the pathogenesis of noise-induced hearing loss …
The role of antioxidants in protection from impulse noise.
Henderson D, McFadden SL, Liu CC, Hight N, Zheng XY. Henderson D, et al. Ann N Y Acad Sci. 1999 Nov 28;884:368-80. doi: 10.1111/j.1749-6632.1999.tb08655.x. Ann N Y Acad Sci. 1999. PMID: 10842607 Review.
The hearing loss from exposure to noise and ototoxic drugs share a number of audiological and pathological similarities. Recent research has shown that reactive oxygen species (ROS) may be a common factor in both noise- and drug-induced heari …
The hearing loss from exposure to noise and ototoxic drugs share a number of audiological and pathological similarities …
l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro.
Tillinger JA, Gupta C, Ila K, Ahmed J, Mittal J, Van De Water TR, Eshraghi AA. Tillinger JA, et al. Acta Otolaryngol. 2018 Aug;138(8):676-684. doi: 10.1080/00016489.2018.1440086. Epub 2018 Mar 7. Acta Otolaryngol. 2018. PMID: 29513056
TNFalpha can potentially play a significant role in hair cell loss following an insult to the inner ear. l-NAC has shown to provide effective protection against noise-induced hearing loss in laboratory animals but mechanisms of thi …
TNFalpha can potentially play a significant role in hair cell loss following an insult to the inner ear. l-NAC has show …
In vitro characterization of novel hyaluronan-antioxidant conjugates as potential topical therapeutics against hearing loss.
Arrigali EM, Veit JGS, Birru B, Van Tine J, Sandau KC, Barrett-Catton E, Tonnerre Z, Serban MA. Arrigali EM, et al. Front Pharmacol. 2024 Feb 28;15:1355279. doi: 10.3389/fphar.2024.1355279. eCollection 2024. Front Pharmacol. 2024. PMID: 38482050 Free PMC article.
Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment options often require invasive medical procedures, and to date, there are no FDA-approved drug therapies. While the causes can be diverse, noise induce …
Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment options often require …