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Refractory and resistant hypertension: characteristics and differences observed in a specialized clinic.
Modolo R, de Faria AP, Sabbatini AR, Barbaro NR, Ritter AM, Moreno H. Modolo R, et al. J Am Soc Hypertens. 2015 May;9(5):397-402. doi: 10.1016/j.jash.2015.03.005. Epub 2015 Mar 19. J Am Soc Hypertens. 2015. PMID: 25979412
Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite the use of 3 anti-hypertensive drugs, or controlled requiring use of 4 drugs. Recently, a new definition for an extreme phenotype of RH (uncontrolled BP using at least f …
Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite the use of 3 anti-hypertensive …
Refractory Hypertension: Evidence of Heightened Sympathetic Activity as a Cause of Antihypertensive Treatment Failure.
Dudenbostel T, Acelajado MC, Pisoni R, Li P, Oparil S, Calhoun DA. Dudenbostel T, et al. Hypertension. 2015 Jul;66(1):126-33. doi: 10.1161/HYPERTENSIONAHA.115.05449. Epub 2015 May 18. Hypertension. 2015. PMID: 25987662 Free PMC article.
Refractory hypertension is an extreme phenotype of treatment failure defined as uncontrolled blood pressure in spite of 5 classes of antihypertensive agents, including chlorthalidone and a mineralocorticoid receptor antagonist. ...Refr …
Refractory hypertension is an extreme phenotype of treatment failure defined as uncontrolled blood pressure in s …
Efficacy of angiotensin receptor neprilysin inhibitor in Asian patients with refractory hypertension.
Li W, Gong M, Yu Q, Liu R, Chen K, Lv W, Yao F, Xu Z, Xu Y, Song W, Jiang Y. Li W, et al. J Clin Hypertens (Greenwich). 2022 Apr;24(4):449-456. doi: 10.1111/jch.14454. Epub 2022 Mar 7. J Clin Hypertens (Greenwich). 2022. PMID: 35253964 Free PMC article.
Sacubitril/valsartan, simultaneously inhibits neprilysin and angiotensin II receptor, showed an effect in reducing blood pressure (BP). The authors aimed to study whether it can be used as an antihypertensive agent in patients with refractory hypert …
Sacubitril/valsartan, simultaneously inhibits neprilysin and angiotensin II receptor, showed an effect in reducing blood pressure …
Comparison of ambulatory blood pressure-lowering effects of higher doses of different calcium antagonists in uncontrolled hypertension: the Calcium Antagonist Controlled-Release High-Dose Therapy in Uncontrolled Refractory Hypertensive Patients (CARILLON) Study.
Mizuno H, Hoshide S, Tomitani N, Kario K. Mizuno H, et al. Blood Press. 2017 Oct;26(5):284-293. doi: 10.1080/08037051.2017.1329623. Epub 2017 May 19. Blood Press. 2017. PMID: 28524699 Clinical Trial.
BACKGROUND: Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high dose in both nifedipine controlled-release (CR) and amlodipine. ...The nifedipine group demonstrated a significant decrease in their urinary …
BACKGROUND: Data are sparse regarding ambulatory blood pressure (BP) reduction of up-titration from a standard dose to a high …
Precision Medicine in Patients With Resistant Hypertension and Obstructive Sleep Apnea: Blood Pressure Response to Continuous Positive Airway Pressure Treatment.
Sánchez-de-la-Torre M, Khalyfa A, Sánchez-de-la-Torre A, Martinez-Alonso M, Martinez-García MÁ, Barceló A, Lloberes P, Campos-Rodriguez F, Capote F, Diaz-de-Atauri MJ, Somoza M, González M, Masa JF, Gozal D, Barbé F; Spanish Sleep Network. Sánchez-de-la-Torre M, et al. J Am Coll Cardiol. 2015 Sep 1;66(9):1023-32. doi: 10.1016/j.jacc.2015.06.1315. J Am Coll Cardiol. 2015. PMID: 26314530 Free article. Clinical Trial.
BACKGROUND: In patients with resistant hypertension (RH) and obstructive sleep apnea (OSA), the blood pressure response to continuous positive airway pressure (CPAP) treatment is highly variable and could be associated with differential micro-ribonucle …
BACKGROUND: In patients with resistant hypertension (RH) and obstructive sleep apnea (OSA), the blood pressure response …
Plasma 8-isoprostane levels are associated with endothelial dysfunction in resistant hypertension.
de Faria AP, Fontana V, Modolo R, Barbaro NR, Sabbatini AR, Pansani IF, Ferreira-Melo SE, Moreno H. de Faria AP, et al. Clin Chim Acta. 2014 Jun 10;433:179-83. doi: 10.1016/j.cca.2014.03.009. Epub 2014 Mar 19. Clin Chim Acta. 2014. PMID: 24657423
BACKGROUND: Impaired endothelial function and arterial stiffness are associated with hypertension and are important risk factors for cardiovascular events. Reactive oxygen species reduce nitric oxide bioavailability and have a pivotal role in endothelial function. R …
BACKGROUND: Impaired endothelial function and arterial stiffness are associated with hypertension and are important risk facto …
A Late Diagnosis of Primary Aldosteronism.
Zorzi F, Olivieri O, Brazzarola P, Pizzolo F. Zorzi F, et al. High Blood Press Cardiovasc Prev. 2017 Sep;24(3):347-349. doi: 10.1007/s40292-017-0191-6. Epub 2017 Mar 14. High Blood Press Cardiovasc Prev. 2017. PMID: 28293914
We report the case of a 41-year-old male patient with juvenile onset refractory hypertension while taking four drugs including a diuretic. ...At the re-evaluation ARR was elevated, and the further workup for primary aldosteronism demonstrated an unilateral aldostero …
We report the case of a 41-year-old male patient with juvenile onset refractory hypertension while taking four drugs including …
[Neurovascular compression of the medulla oblongata: a rare cause of secondary hypertension].
Nádas J, Czirják S, Igaz P, Vörös E, Jermendy G, Rácz K, Tóth M. Nádas J, et al. Orv Hetil. 2014 May 25;155(21):838-42. doi: 10.1556/OH.2014.29908. Orv Hetil. 2014. PMID: 24836320 Hungarian.
In the first six months after the operation, the patient's blood pressure could be kept in the normal range with significantly reduced doses of antihypertensive medication. ...In the majority of patients surgery results in a significant decrease of blood …
In the first six months after the operation, the patient's blood pressure could be kept in the normal range with significantly …
Refractory hypertension is associated with the haptoglobin 2-2 phenotype.
Delanghe JR, Duprez DA, De Buyzere ML, Bergez BM, Claeys LR, Leroux-Roels GG, Clement DL. Delanghe JR, et al. J Cardiovasc Risk. 1995 Apr;2(2):131-6. J Cardiovasc Risk. 1995. PMID: 7606649
BACKGROUND: Many cases of refractory hypertension cannot be attributed to specific identifiable factors. ...RESULTS: In the group of patients with refractory hypertension, the relative allele frequency of haptoglobin 1 (0.266) was lower than in the gro …
BACKGROUND: Many cases of refractory hypertension cannot be attributed to specific identifiable factors. ...RESULTS: In the gr …