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54 results

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Bacterial mutagenicity assays: Vehicle and positive control results from the standard Ames assay, the 6- and 24-well miniaturized plate incorporation assays and the Ames II assay.
Pant K, Bruce S, Sly J, Klug Laforce M, Springer S, Cecil M, Andrus E, Dakoulas E, Wagner VO 3rd, Hewitt NJ, Kulkarni R. Pant K, et al. Environ Mol Mutagen. 2016 Jul;57(6):483-96. doi: 10.1002/em.22014. Epub 2016 May 20. Environ Mol Mutagen. 2016. PMID: 27198925
The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay, required for regulatory submissions. Higher throughput non-OECD 471 TG assays, such as the miniaturized plate incorporation and Ames …
The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay, required for regul …
The micro-Ames test: A direct comparison of the performance and sensitivities of the standard and 24-well plate versions of the bacterial mutation test.
Proudlock R, Evans K. Proudlock R, et al. Environ Mol Mutagen. 2016 Dec;57(9):687-705. doi: 10.1002/em.22065. Epub 2016 Nov 16. Environ Mol Mutagen. 2016. PMID: 27862311
Given their importance, pre-screening 'miniaturized' versions have been developed which allow higher throughput and use less test material, including the widely-employed 24-well micro-Ames (Ames) test which uses 20 times less material. ...Historical co …
Given their importance, pre-screening 'miniaturized' versions have been developed which allow higher throughput and use less test mat …
Genotoxicity testing and biomarker studies on surface waters: an overview of the techniques and their efficacies.
Tabrez S, Shakil S, Urooj M, Damanhouri GA, Abuzenadah AM, Ahmad M. Tabrez S, et al. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2011 Jul;29(3):250-75. doi: 10.1080/10590501.2011.601849. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2011. PMID: 21929382 Review.
An overview, highlighting the genotoxicity testing system, such as Ames plate incorporation test, Ames fluctuation test, E. coli survival assay, Allium cepa toxicity/genotoxicity test, comet assay, and plasmid nicking …
An overview, highlighting the genotoxicity testing system, such as Ames plate incorporation test, Ames fl …
Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of beta-chloroprene.
Valentine R, Himmelstein MW. Valentine R, et al. Chem Biol Interact. 2001 Jun 1;135-136:81-100. doi: 10.1016/s0009-2797(01)00218-6. Chem Biol Interact. 2001. PMID: 11397383 Review.
.; no effects on reproductive parameters or histopathology were found. CD is nonmutagenic in standard plate incorporation bacterial reverse mutation assays (Ames assays) but positive using direct gas-phase incubation methods. ...
.; no effects on reproductive parameters or histopathology were found. CD is nonmutagenic in standard plate incorporation bact …
Evaluation of 4-methylimidazole, in the Ames/Salmonella test using induced rodent liver and lung S9.
Beevers C, Adamson RH. Beevers C, et al. Environ Mol Mutagen. 2016 Jan;57(1):51-7. doi: 10.1002/em.21968. Epub 2015 Sep 10. Environ Mol Mutagen. 2016. PMID: 26765635
The 4-MeI was tested for its ability to induce mutation in five standard Ames strains of S. typhimurium using induced rat (F344/N) and mouse (B6C3F1) liver and lung S9 as a source of exogenous metabolism. The chemicals were tested in an OECD 471-compliant bacterial reverse …
The 4-MeI was tested for its ability to induce mutation in five standard Ames strains of S. typhimurium using induced rat (F344/N) an …
The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100.
Thorne D, Crooks I, Hollings M, Seymour A, Meredith C, Gaca M. Thorne D, et al. Mutat Res Genet Toxicol Environ Mutagen. 2016 Dec;812:29-38. doi: 10.1016/j.mrgentox.2016.10.005. Epub 2016 Oct 29. Mutat Res Genet Toxicol Environ Mutagen. 2016. PMID: 27908385 Free article.
Results obtained were compared to those for the mainstream smoke from a Kentucky reference (3R4F) cigarette. Two different test matrices were assessed. Aerosol generated from the e-cigarette was trapped on a Cambridge filter pad, eluted in DMSO and compared to cigarette sm …
Results obtained were compared to those for the mainstream smoke from a Kentucky reference (3R4F) cigarette. Two different test matri …
Mutagenicity and anti-mutagenicity of Acanthopanax divaricatus var. albeofructus.
Hong CE, Cho MC, Jang HA, Lyu SY. Hong CE, et al. J Toxicol Sci. 2011 Oct;36(5):661-8. doi: 10.2131/jts.36.661. J Toxicol Sci. 2011. PMID: 22008541 Free article.
The beneficial effects of Acanthopanax divaricatus var. albeofructus (ADA) extracts have been assessed by mutagenic and anti-mutagenic activities by Ames test. Mutation of Salmonella typhimurium strains TA 98, TA 100, TA1535, TA1537, and Escherichia coli WP2 uvr A w …
The beneficial effects of Acanthopanax divaricatus var. albeofructus (ADA) extracts have been assessed by mutagenic and anti-mutagenic activ …
International round-robin study on the Ames fluctuation test.
Reifferscheid G, Maes HM, Allner B, Badurova J, Belkin S, Bluhm K, Brauer F, Bressling J, Domeneghetti S, Elad T, Flückiger-Isler S, Grummt HJ, Gürtler R, Hecht A, Heringa MB, Hollert H, Huber S, Kramer M, Magdeburg A, Ratte HT, Sauerborn-Klobucar R, Sokolowski A, Soldan P, Smital T, Stalter D, Venier P, Ziemann C, Zipperle J, Buchinger S. Reifferscheid G, et al. Environ Mol Mutagen. 2012 Apr;53(3):185-97. doi: 10.1002/em.21677. Epub 2012 Jan 4. Environ Mol Mutagen. 2012. PMID: 22246666
An international round-robin study on the Ames fluctuation test [ISO 11350, 2012], a microplate version of the classic plate-incorporation method for the detection of mutagenicity in water, wastewater and chemicals was performed by 18 laboratories from …
An international round-robin study on the Ames fluctuation test [ISO 11350, 2012], a microplate version of the classic plat …
Safety of micronized palmitoylethanolamide (microPEA): lack of toxicity and genotoxic potential.
Nestmann ER. Nestmann ER. Food Sci Nutr. 2016 Jun 15;5(2):292-309. doi: 10.1002/fsn3.392. eCollection 2017 Mar. Food Sci Nutr. 2016. PMID: 28265364 Free PMC article.
MicroPEA of defined particle size (0.5-10 mum) was evaluated for mutagenicity in Salmonella typhimurium, for clastogenicity/aneuploidy in cultured human lymphocytes, and for acute and subchronic rodent toxicity in the rat, following standard OECD test protocols, in accorda …
MicroPEA of defined particle size (0.5-10 mum) was evaluated for mutagenicity in Salmonella typhimurium, for clastogenicity/aneuploidy in cu …
A modified Ames assay reveals the mutagenicity of native cigarette mainstream smoke and its gas vapour phase.
Aufderheide M, Gressmann H. Aufderheide M, et al. Exp Toxicol Pathol. 2007 Aug;58(6):383-92. doi: 10.1016/j.etp.2007.02.002. Epub 2007 Jun 6. Exp Toxicol Pathol. 2007. PMID: 17555953
In comparison to studies using the plate incorporation assay, the direct exposure of bacteria to smoke on the agar surface enhances contact to the aerosols. ...Our alternative procedure of exposing bacteria directly to gases and complex mixtures offers new po …
In comparison to studies using the plate incorporation assay, the direct exposure of bacteria to smoke on the agar surf …
54 results