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1993 2
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223 results

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Page 1
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Corder EH, et al. Science. 1993 Aug 13;261(5123):921-3. doi: 10.1126/science.8346443. Science. 1993. PMID: 8346443
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). ...
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic …
Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations.
Reitz C, Mayeux R. Reitz C, et al. Biol Psychiatry. 2014 Apr 1;75(7):534-41. doi: 10.1016/j.biopsych.2013.06.003. Epub 2013 Jul 25. Biol Psychiatry. 2014. PMID: 23890735 Free PMC article. Review.
Late-onset Alzheimer's disease (LOAD), which is characterized by progressive deterioration in cognition, function, and behavior, is the most common cause of dementia and the sixth leading cause of all deaths, placing a considerable burden on Western societies …
Late-onset Alzheimer's disease (LOAD), which is characterized by progressive deterioration in cognition, function, and …
Apolipoprotein E region molecular signatures of Alzheimer's disease.
Kulminski AM, Huang J, Wang J, He L, Loika Y, Culminskaya I. Kulminski AM, et al. Aging Cell. 2018 Aug;17(4):e12779. doi: 10.1111/acel.12779. Epub 2018 May 23. Aging Cell. 2018. PMID: 29797398 Free PMC article.
Although the APOE region is the strongest genetic risk factor for Alzheimer's diseases (ADs), its pathogenic role remains poorly understood. ...This uncertainty is inevitable source of natural-selection-free genetic heterogeneity in predisposition to ADs. We perform …
Although the APOE region is the strongest genetic risk factor for Alzheimer's diseases (ADs), its pathogenic role remains poor …
Genetic and regulatory architecture of Alzheimer's disease in the APOE region.
Kulminski AM, Shu L, Loika Y, He L, Nazarian A, Arbeev K, Ukraintseva S, Yashin A, Culminskaya I. Kulminski AM, et al. Alzheimers Dement (Amst). 2020 Feb 6;12(1):e12008. doi: 10.1002/dad2.12008. eCollection 2020. Alzheimers Dement (Amst). 2020. PMID: 32211503 Free PMC article.
INTRODUCTION: Apolipoprotein E (APOE) epsilon2 and epsilon4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro "risk" factors for Alzheimer's disease (AD). METHODS: We examined differences in linka …
INTRODUCTION: Apolipoprotein E (APOE) epsilon2 and epsilon4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively …
Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016.
Srivastava AK, Wang Y, Huang R, Skinner C, Thompson T, Pollard L, Wood T, Luo F, Stevenson R, Polimanti R, Gelernter J, Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Yap F, Kwek K, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group; Kapoor A, Lee D, Chakravarti A, Maercker C, Graf F, Boutros M, Stamoulis G, Santoni F, Makrythanasis P, Letourneau A, Guipponi M, Panousis N, Garieri M, Ribaux P, Falconnet E, Borel C, Antonarakis SE, Kumar S, Curran J, Blangero J, Chatterjee S, Kapoor A, Akiyama J, Auer D, Berrios C, Pennacchio L, Chakravarti A, Donti TR, Cappuccio G, Miller M, Atwal P, Kennedy A, Cardon A, Bacino C, Emrick L, Hertecant J, Baumer F, Porter B, Bainbridge M, Bonnen P, Graham B, Sutton R, Sun Q, Elsea S, Hu Z, Wang P, Zhu Y, Zhao J, Xiong M, Bennett DA, Hidalgo-Miranda A, Romero-Cordoba S, Rodriguez-Cuevas S, Rebollar-Vega R, Tagliabue E, Iorio M, D’Ippolito E, Baroni S, Kaczkowski B, Tanaka Y, Kawaji H, Sandelin A, Andersson R, Itoh M, Lassmann T; The FANTOM5 Consortium; Hayashizaki Y, Carninci P, Forrest ARR, Semple CA, Rosenthal EA, Shirts B, Amendola L, Gallego C, Horike-Pyne… See abstract for full author list ➔ Srivastava AK, et al. Hum Genomics. 2016 May 26;10 Suppl 1(Suppl 1):12. doi: 10.1186/s40246-016-0063-5. Hum Genomics. 2016. PMID: 27294413 Free PMC article.
Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer's disease Z. Hu, P. Wang, Y. Zhu, J. Zhao, M. Xiong, David A Bennett O11 A microRNA signature identifies subtypes of triple-negative breast cancer and reveals MIR-342-3P as regulator o …
Sun, S. Elsea O10 A novel causal methylation network approach to Alzheimer's disease Z. Hu, P. Wang, Y. Zhu, J. Zhao, M …
Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks.
Maestre G, Ottman R, Stern Y, Gurland B, Chun M, Tang MX, Shelanski M, Tycko B, Mayeux R. Maestre G, et al. Ann Neurol. 1995 Feb;37(2):254-9. doi: 10.1002/ana.410370217. Ann Neurol. 1995. PMID: 7847867
The presence of the apolipoprotein epsilon 4 (apo epsilon 4) allele significantly increases the risk of Alzheimer's disease. Whether this is due to biological effects of the apo epsilon 4 protein or reflects linkage disequilibrium with an as yet …
The presence of the apolipoprotein epsilon 4 (apo epsilon 4) allele significantly increases the risk of Alzheimer's disease …
Genetic association of BIN1 and GAB2 in Alzheimer's disease: A meta-analysis and systematic review.
Hao X, Wang A, Li C, Shao L, Li Y, Yang P. Hao X, et al. Geriatr Gerontol Int. 2021 Feb;21(2):185-191. doi: 10.1111/ggi.14109. Epub 2020 Dec 16. Geriatr Gerontol Int. 2021. PMID: 33331110 Free PMC article.
AIM: Heredity plays an important role in the pathogenesis of Alzheimer's disease (AD) especially for single-nucleotide polymorphism (SNPs) of susceptible genes, which is one of the significant factors in the pathogenesis of AD. ...CONCLUSIONS: BIN1 rs744373, …
AIM: Heredity plays an important role in the pathogenesis of Alzheimer's disease (AD) especially for single-nucleotide …
Inter- and intra-chromosomal modulators of the APOE e2 and e4 effects on the Alzheimer's disease risk.
Nazarian A, Philipp I, Culminskaya I, He L, Kulminski AM. Nazarian A, et al. Geroscience. 2023 Feb;45(1):233-247. doi: 10.1007/s11357-022-00617-0. Epub 2022 Jul 9. Geroscience. 2023. PMID: 35809216 Free PMC article.
The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) epsilon2 and epsilon4 alleles on Alzheimer's disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage …
The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) epsilon2 and epsilon4 alleles on …
Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.
Roses A, Sundseth S, Saunders A, Gottschalk W, Burns D, Lutz M. Roses A, et al. Alzheimers Dement. 2016 Jun;12(6):687-94. doi: 10.1016/j.jalz.2016.03.015. Epub 2016 May 4. Alzheimers Dement. 2016. PMID: 27154058 Free article. Review.
Translation to clinical utility has been limited, especially in Alzheimer's Disease (AD). It has become standard practice in the analyses of more than two dozen AD GWAS studies to exclude the apolipoprotein E (APOE) region because of its extraor …
Translation to clinical utility has been limited, especially in Alzheimer's Disease (AD). It has become standard practi …
223 results