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Combination Tissue Plasminogen Activator and DNase for Loculated Malignant Pleural Effusions: A Single-center Retrospective Review.
Chan C, Sekowski V, Zheng B, Li P, Stollery D, Veenstra J, Gillson AM. Chan C, et al. J Bronchology Interv Pulmonol. 2023 Jul 1;30(3):238-243. doi: 10.1097/LBR.0000000000000871. J Bronchology Interv Pulmonol. 2023. PMID: 35698287 Free PMC article.
BACKGROUND: Indwelling pleural catheters (IPCs) are frequently used for the management of malignant pleural effusions (MPEs), but drainage can be impaired by pleural loculations. We aimed to evaluate the safety and effectiveness of intrapleural tiss …
BACKGROUND: Indwelling pleural catheters (IPCs) are frequently used for the management of malignant pleural effusions ( …
Intrapleural Fibrinolytic Therapy With Alteplase for the Management of Multiloculated Malignant Pleural Effusion: A Case Series.
Nemet M, Vasilić M, Ergelašev S, Kuhajda I, Ergelašev I. Nemet M, et al. Cureus. 2022 Aug 1;14(8):e27549. doi: 10.7759/cureus.27549. eCollection 2022 Aug. Cureus. 2022. PMID: 36059301 Free PMC article.
Malignant pleural effusion refers to the presence of fluid in the pleural space due to an underlying malignancy. Malignant pleural effusion is sometimes accompanied by the formation of fibrous adhesions resulting in a multiloculate …
Malignant pleural effusion refers to the presence of fluid in the pleural space due to an underlying malignancy. …
Effect of repeated thoracenteses on fluid characteristics, cytokines, and fibrinolytic activity in malignant pleural effusion.
Chung CL, Chen YC, Chang SC. Chung CL, et al. Chest. 2003 Apr;123(4):1188-95. doi: 10.1378/chest.123.4.1188. Chest. 2003. PMID: 12684310
OBJECTIVE: To evaluate the effect of repeated thoracenteses on the fluid characteristics and the levels of various cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-5, IL-6, and IL-8, and of plasminogen activator inhibitor type 1 (PA …
OBJECTIVE: To evaluate the effect of repeated thoracenteses on the fluid characteristics and the levels of various cytokines, including tumo …
Intrapleural Fibrinolytics and Deoxyribonuclease for Treatment of Indwelling Pleural Catheter-Related Pleural Infection: A Multi-Center Observational Study.
Fitzgerald DB, Muruganandan S, Tsim S, Ip H, Asciak R, Walker S, Uribe Becerra JP, Majid A, Ahmed L, Rahman NM, Maskell NA, Blyth KG, Lee YCG. Fitzgerald DB, et al. Respiration. 2021;100(5):452-460. doi: 10.1159/000514643. Epub 2021 Mar 30. Respiration. 2021. PMID: 33784710
BACKGROUND: Indwelling pleural catheters (IPC) are increasingly used for management of recurrent (especially malignant) effusions. Pleural infection associated with IPC use remains a concern. Intrapleural therapy with tissue plasminogen activ …
BACKGROUND: Indwelling pleural catheters (IPC) are increasingly used for management of recurrent (especially malignant) effusi …
[Improve the clinical research and standardize the management of pleural diseases].
Wang Z, Shi HZ. Wang Z, et al. Zhonghua Yi Xue Za Zhi. 2022 May 25;102(24):1786-1789. doi: 10.3760/cma.j.cn112137-20220215-00315. Online ahead of print. Zhonghua Yi Xue Za Zhi. 2022. PMID: 35701089 Chinese.
Based on the clinical evidence obtained during the past decade, we reviewed herein the evidences in the treatment of 5 types of common pleural diseases. (1) Therapeutic pleural interventions are not recommended for patients with malignant pleural ef …
Based on the clinical evidence obtained during the past decade, we reviewed herein the evidences in the treatment of 5 types of common pl …
Intrapleural Fibrinolytic Therapy Improves Results With Talc Slurry Pleurodesis.
Bellini A, Tarrazzi F, Tami C, Patino SH, Block M. Bellini A, et al. Cureus. 2020 Aug 29;12(8):e10122. doi: 10.7759/cureus.10122. Cureus. 2020. PMID: 33005537 Free PMC article.
Objective Talc slurry pleurodesis (TSP) can lead to permanent small loculations. Intrapleural tissue plasminogen activator (tPA) breaks down loculations, and therefore may improve results but may also inhibit pleurodesis. tPA was given with and …
Objective Talc slurry pleurodesis (TSP) can lead to permanent small loculations. Intrapleural tissue plasminogen act …
Pleural fibrinolytic activity is decreased in inflammation as demonstrated in quinacrine pleurodesis treatment of malignant pleural effusion.
Agrenius V, Chmielewska J, Widström O, Blombäck M. Agrenius V, et al. Am Rev Respir Dis. 1989 Nov;140(5):1381-5. doi: 10.1164/ajrccm/140.5.1381. Am Rev Respir Dis. 1989. PMID: 2817601
Chronic malignant pleural exudation is generally characterized by little or no fibrin deposition. ...The plasminogen activator inhibitor PAI-1, which plays an important role in the regulation of fibrinolysis, was also studied during treatment. ...
Chronic malignant pleural exudation is generally characterized by little or no fibrin deposition. ...The plasminogen …
[The effect of intrapleural pingyangmycin administration on activity of fibrinolytic system and transforming growth factor-beta1 in malignant pleural effusion].
Zhu QQ, Sun GY. Zhu QQ, et al. Zhonghua Jie He He Hu Xi Za Zhi. 2009 Sep;32(9):674-8. Zhonghua Jie He He Hu Xi Za Zhi. 2009. PMID: 20079281 Chinese.
OBJECTIVE: To observe the changes of the concentrations of plasminogen activator inhibitor-1(PAI-1), tissue-type plasminogen activator(t-PA), transforming growth factor-beta(1)(TGF-beta(1)) in peripheral blood and pleural effusion …
OBJECTIVE: To observe the changes of the concentrations of plasminogen activator inhibitor-1(PAI-1), tissue-type pla …