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Items: 1 to 20 of 107

1.

Photocontrolled exposure of pro-apoptotic peptide sequences in LOV proteins modulate Bcl-2 family interactions.

Mart R, Meah D, Allemann RK.

Chembiochem. 2015 Oct 23. doi: 10.1002/cbic.201500469. [Epub ahead of print]

PMID:
26493687
2.

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Luk LY, Ruiz-Pernía JJ, Adesina AS, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9016-20. doi: 10.1002/anie.201503968. Epub 2015 Jun 16.

PMID:
26079622
3.

Protein motions and dynamic effects in enzyme catalysis.

Luk LY, Loveridge EJ, Allemann RK.

Phys Chem Chem Phys. 2015 Nov 18;17(46):30817-27. doi: 10.1039/c5cp00794a.

PMID:
25854702
4.

Novel olfactory ligands via terpene synthases.

Touchet S, Chamberlain K, Woodcock CM, Miller DJ, Birkett MA, Pickett JA, Allemann RK.

Chem Commun (Camb). 2015 May 1;51(35):7550-3. doi: 10.1039/c5cc01814e.

PMID:
25847629
5.

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26.

PMID:
25396728
6.

Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase.

Gonzalez V, Touchet S, Grundy DJ, Faraldos JA, Allemann RK.

J Am Chem Soc. 2014 Oct 15;136(41):14505-12. doi: 10.1021/ja5066366. Epub 2014 Oct 2.

7.

The structural basis of differential inhibition of human calpain by indole and phenyl α-mercaptoacrylic acids.

Adams SE, Rizkallah PJ, Miller DJ, Robinson EJ, Hallett MB, Allemann RK.

J Struct Biol. 2014 Sep;187(3):236-41. doi: 10.1016/j.jsb.2014.07.004. Epub 2014 Jul 30.

PMID:
25086406
8.

Role of the occluded conformation in bacterial dihydrofolate reductases.

Behiry EM, Luk LY, Matthews SM, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4761-8. doi: 10.1021/bi500507v. Epub 2014 Jul 18.

9.

Loop interactions during catalysis by dihydrofolate reductase from Moritella profunda.

Behiry EM, Evans RM, Guo J, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4769-74. doi: 10.1021/bi500508z. Epub 2014 Jul 18.

10.

Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.

Luk LY, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2014 May 14;136(19):6862-5. doi: 10.1021/ja502673h. Epub 2014 May 5.

11.

Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.

Guo J, Luk LY, Loveridge EJ, Allemann RK.

Biochemistry. 2014 May 6;53(17):2855-63. doi: 10.1021/bi500238q. Epub 2014 Apr 22.

12.

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

Ruiz-Pernia JJ, Luk LY, García-Meseguer R, Martí S, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2013 Dec 11;135(49):18689-96. doi: 10.1021/ja410519h. Epub 2013 Nov 26.

13.

Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?

Miller DJ, Adams SE, Hallett MB, Allemann RK.

Future Med Chem. 2013 Nov;5(17):2057-74. doi: 10.4155/fmc.13.172. Review.

PMID:
24215346
14.

Conformational change and ligand binding in the aristolochene synthase catalytic cycle.

van der Kamp MW, Sirirak J, Żurek J, Allemann RK, Mulholland AJ.

Biochemistry. 2013 Nov 12;52(45):8094-105. doi: 10.1021/bi400898k. Epub 2013 Oct 29.

PMID:
24106830
15.

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.

Luk LY, Javier Ruiz-Pernía J, Dawson WM, Roca M, Loveridge EJ, Glowacki DR, Harvey JN, Mulholland AJ, Tuñón I, Moliner V, Allemann RK.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16344-9. doi: 10.1073/pnas.1312437110. Epub 2013 Sep 24.

16.

BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells.

Mart RJ, Errington RJ, Watkins CL, Chappell SC, Wiltshire M, Jones AT, Smith PJ, Allemann RK.

Mol Biosyst. 2013 Nov;9(11):2597-603. doi: 10.1039/c3mb70246d.

PMID:
23942570
17.

Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.

Chen M, Al-lami N, Janvier M, D'Antonio EL, Faraldos JA, Cane DE, Allemann RK, Christianson DW.

Biochemistry. 2013 Aug 13;52(32):5441-53. doi: 10.1021/bi400691v. Epub 2013 Aug 1.

18.

Effect of dimerization on dihydrofolate reductase catalysis.

Guo J, Loveridge EJ, Luk LY, Allemann RK.

Biochemistry. 2013 Jun 4;52(22):3881-7. doi: 10.1021/bi4005073. Epub 2013 May 22.

PMID:
23672258
19.

Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.

Li JX, Fang X, Zhao Q, Ruan JX, Yang CQ, Wang LJ, Miller DJ, Faraldos JA, Allemann RK, Chen XY, Zhang P.

Biochem J. 2013 May 1;451(3):417-26. doi: 10.1042/BJ20130041.

PMID:
23438177
20.

Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.

Faraldos JA, Gonzalez V, Li A, Yu F, Köksal M, Christianson DW, Allemann RK.

J Am Chem Soc. 2012 Dec 26;134(51):20844-8. doi: 10.1021/ja311022s. Epub 2012 Dec 11.

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