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A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease.
Siblerud R, Mutter J, Moore E, Naumann J, Walach H. Siblerud R, et al. Int J Environ Res Public Health. 2019 Dec 17;16(24):5152. doi: 10.3390/ijerph16245152. Int J Environ Res Public Health. 2019. PMID: 31861093 Free PMC article.
Genetic factors in patients with Alzheimer's disease are also associated with mercury. Apolipoprotein E 4 allele increases the toxicity of mercury. ...Conclusion: This review of the literature strongly suggests that mercury can be a cause of Alzheim …
Genetic factors in patients with Alzheimer's disease are also associated with mercury. Apolipoprotein E 4 allele …
The study of genetic polymorphisms related to serotonin in Alzheimer's disease: a new perspective in a heterogenic disorder.
Oliveira JR, Zatz M. Oliveira JR, et al. Braz J Med Biol Res. 1999 Apr;32(4):463-7. doi: 10.1590/s0100-879x1999000400014. Braz J Med Biol Res. 1999. PMID: 10347811 Review.
Genetic and environmental factors have been implicated in the development of Alzheimer's disease (AD), the most common form of dementia in the elderly. Mutations in 3 genes mapped on chromosomes 21, 14 and 1 are related to the rare early onset forms of …
Genetic and environmental factors have been implicated in the development of Alzheimer's disease (AD), the most common …
Behavioral genetics of neurodegenerative disorders.
Galimberti D, Scarpini E. Galimberti D, et al. Curr Top Behav Neurosci. 2012;12:615-31. doi: 10.1007/7854_2011_181. Curr Top Behav Neurosci. 2012. PMID: 22261700 Review.
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and is typically characterized by memory loss. ...A number of additional genetic factors,including cytokines, chemokines, Nitric Oxide Synthases, contribute to the susceptibility fo …
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and is typically characterized by memory …
Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease.
Pritchard AL, Harris J, Pritchard CW, Coates J, Haque S, Holder R, Bentham P, Lendon CL. Pritchard AL, et al. Neurobiol Aging. 2008 Mar;29(3):341-7. doi: 10.1016/j.neurobiolaging.2006.10.011. Epub 2006 Nov 13. Neurobiol Aging. 2008. PMID: 17098333
OBJECTIVE: Alzheimer's disease (AD) patients suffer from behavioural and psychological symptoms of dementia (BPSD). ...These measures were related to the 5HT(2A) T102C and 5HT(2C) cys23ser genotype and allele frequencies. RESULTS: Our data supports pre …
OBJECTIVE: Alzheimer's disease (AD) patients suffer from behavioural and psychological symptoms of dementia (BPSD). ... …
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW. Lu XH, et al. Sci Transl Med. 2014 Dec 24;6(268):268ra178. doi: 10.1126/scitranslmed.3010523. Sci Transl Med. 2014. PMID: 25540325
Age-related neurodegenerative disorders including Alzheimer's disease and Huntington's disease (HD) consistently show elevated DNA damage, but the relevant molecular pathways in disease pathogenesis remain unclear. ...Persistently elevated ATM s …
Age-related neurodegenerative disorders including Alzheimer's disease and Huntington's disease (HD) consistently …
Association between 5-HT(2A) receptor polymorphism and psychotic symptoms in Alzheimer's disease.
Nacmias B, Tedde A, Forleo P, Piacentini S, Guarnieri BM, Bartoli A, Ortenzi L, Petruzzi C, Serio A, Marcon G, Sorbi S. Nacmias B, et al. Biol Psychiatry. 2001 Sep 15;50(6):472-5. doi: 10.1016/s0006-3223(01)01114-3. Biol Psychiatry. 2001. PMID: 11566166
BACKGROUND: The aim of this study is to analyze the segregation of the 102T/C polymorphism in the serotonin 2A receptor gene in patients affected by sporadic and familial Alzheimer's disease (FAD) with and without psychotic symptoms. ...A semistructure …
BACKGROUND: The aim of this study is to analyze the segregation of the 102T/C polymorphism in the serotonin 2A receptor gene in patie …
Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease.
Li T, Holmes C, Sham PC, Vallada H, Birkett J, Kirov G, Lesch KP, Powell J, Lovestone S, Collier D. Li T, et al. Neuroreport. 1997 Feb 10;8(3):683-6. doi: 10.1097/00001756-199702100-00021. Neuroreport. 1997. PMID: 9106747
We examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an approximately 40% reduction in expression of the protein, in 196 subjects with late onset Alzheimer's disease (AD) and 271 controls. ...These fin …
We examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an approximately 40% reductio …
Association study for a functional serotonin transporter gene polymorphism and late-onset Alzheimer's disease for Chinese patients.
Tsai SJ, Hong CJ, Liu TY, Cheng CY, Liu HC. Tsai SJ, et al. Neuropsychobiology. 2001;44(1):27-30. doi: 10.1159/000054910. Neuropsychobiology. 2001. PMID: 11408789
Two recent studies have demonstrated an association for a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-HTTLPR), and Alzheimer's disease (AD). ...No significant differences were determined for genotype …
Two recent studies have demonstrated an association for a deletion/insertion polymorphism within the promoter region of the serotonin …
Genetic characteristics of dementia in Taiwan.
Chen HH, Hu CJ. Chen HH, et al. Acta Neurol Taiwan. 2006 Sep;15(3):161-9. Acta Neurol Taiwan. 2006. PMID: 16995595 Review.
The most common causes of dementia in Taiwan are Alzheimer's disease (AD) followed by vascular dementia (VaD). Several genetic studies have documented an increased risk of AD among apolipoprotein E gene allele 4 (ApoE4) carriers in Taiwanese (ethnic Ch …
The most common causes of dementia in Taiwan are Alzheimer's disease (AD) followed by vascular dementia (VaD). Several …
Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients.
Zill P, Padberg F, de Jonge S, Hampel H, Bürger K, Stübner S, Boetsch T, Jürgen Möller H, Ackenheil M, Bondy B. Zill P, et al. Neurosci Lett. 2000 Apr 21;284(1-2):113-5. doi: 10.1016/s0304-3940(00)00994-0. Neurosci Lett. 2000. PMID: 10771175
Several studies have attempted to confirm an association between a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-HTT) and Alzheimer's disease independent from the apolipoprotein E (APOE) varepsilon4 sta …
Several studies have attempted to confirm an association between a deletion/insertion polymorphism within the promoter region of the sero …