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Albofungin and chloroalbofungin: antibiotic crystals with 2D but not 3D isostructurality.
Ye W, She W, Sung HHY, Qian P, Williams ID. Ye W, et al. Acta Crystallogr C Struct Chem. 2020 Dec 1;76(Pt 12):1100-1107. doi: 10.1107/S2053229620015041. Epub 2020 Nov 25. Acta Crystallogr C Struct Chem. 2020. PMID: 33273148
The potent antibiotics albofungin [systematic name: (1S,4R,8aR)-13-amino-1,15,16-trihydroxy-4-methoxy-12-methyl-3,4,8a,13-tetrahydro-1H-xantheno[4',3',2':4,5][1,3]benzodioxino[7,6-g]isoquinoline-14,17(2H,9H)-dione, C(27)H(24)N(2)O(9), 1] and its chlorinated analogue chloro …
The potent antibiotics albofungin [systematic name: (1S,4R,8aR)-13-amino-1,15,16-trihydroxy-4-methoxy-12-methyl-3,4,8a,13-tetrahydro- …
Mode of action of antifouling compound albofungin in inhibiting barnacle larval settlement.
She W, Wang H, Linardi D, Chik SY, Lan Y, Chen F, Cheng A, Qian PY. She W, et al. iScience. 2023 May 28;26(7):106981. doi: 10.1016/j.isci.2023.106981. eCollection 2023 Jul 21. iScience. 2023. PMID: 37534162 Free PMC article.
Marine biofouling causes huge economic losses to the marine industry every year. Albofungin is a potential antifoulant showing strong anti-macrofouling activities against larval settlement of major fouling organisms. In the present study, directed RNA-seq and proteomic ana …
Marine biofouling causes huge economic losses to the marine industry every year. Albofungin is a potential antifoulant showing strong …
Genetic and Biochemical Characterization of Halogenation and Drug Transportation Genes Encoded in the Albofungin Biosynthetic Gene Cluster.
Wang ZC, Lo IW, Lin KH, Cheng AN, Zadeh SM, Huang YH, Li TL. Wang ZC, et al. Appl Environ Microbiol. 2022 Sep 13;88(17):e0080622. doi: 10.1128/aem.00806-22. Epub 2022 Aug 24. Appl Environ Microbiol. 2022. PMID: 36000868 Free PMC article.
Albofungin, a hexacyclic aromatic natural product, exhibits broad-spectrum antimicrobial activity. ...Despite that halogenation of albofungin somewhat increases binding affinity to transglycosylase (TGase), albofungin with/without a halogen substituent manife
Albofungin, a hexacyclic aromatic natural product, exhibits broad-spectrum antimicrobial activity. ...Despite that halogenation of
Discovery, Bioactivity Evaluation, Biosynthetic Gene Cluster Identification, and Heterologous Expression of Novel Albofungin Derivatives.
She W, Ye W, Cheng A, Liu X, Tang J, Lan Y, Chen F, Qian PY. She W, et al. Front Microbiol. 2021 Feb 1;12:635268. doi: 10.3389/fmicb.2021.635268. eCollection 2021. Front Microbiol. 2021. PMID: 33633715 Free PMC article.
We conducted a comprehensive chemical investigation for secondary metabolites from the S. chrestomyceticus strain and identified two novel albofungin (alb) derivatives, i.e., albofungins A (1) and B (2), along with two known compounds, i.e., albofungin (3) and chlor …
We conducted a comprehensive chemical investigation for secondary metabolites from the S. chrestomyceticus strain and identified two novel …
Mode of action of antimicrobial agents albofungins in eradicating penicillin- and cephalosporin-resistant Vibrio parahaemolyticus biofilm.
She W, Cheng A, Ye W, Zeng P, Wang H, Qian PY. She W, et al. Microbiol Spectr. 2023 Aug 23;11(5):e0156323. doi: 10.1128/spectrum.01563-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 37610246 Free PMC article.
Albofungin is a promising broad-spectrum antimicrobial compound against multidrug-resistant bacteria. ...We observed membrane disruption and permeation mechanisms in planktonic cells and biofilms after albofungin treatment, while albofungin had a weak interac
Albofungin is a promising broad-spectrum antimicrobial compound against multidrug-resistant bacteria. ...We observed membrane disrupt
Discovery, Yield Improvement, and Application in Marine Coatings of Potent Antifouling Compounds Albofungins Targeting Multiple Fouling Organisms.
She W, Ye W, Cheng A, Ye W, Ma C, Wang R, Cheng J, Liu X, Yuan Y, Chik SY, Limlingan Malit JJ, Lu Y, Chen F, Qian PY. She W, et al. Front Microbiol. 2022 Jul 7;13:906345. doi: 10.3389/fmicb.2022.906345. eCollection 2022. Front Microbiol. 2022. PMID: 35875539 Free PMC article.
We aim to develop high-efficient, less-toxic, and cost-effective antifoulants to solve the problems of biofouling. In this study, we described the antifouling compounds albofungin and its derivatives (albofungin A, chrestoxanthone A, and chloroalbofungin) isolated f …
We aim to develop high-efficient, less-toxic, and cost-effective antifoulants to solve the problems of biofouling. In this study, we describ …
[Albofungin formation by a strain isolated as a result of fusion of protoplasts of organisms producing aminoglycoside antibiotics].
Malanicheva IA, Koz'mian LI, Dudnik IuV, Novozhenov MIu, Laĭko AV, Potapova NP. Malanicheva IA, et al. Antibiot Khimioter. 1991 May;36(5):5-8. Antibiot Khimioter. 1991. PMID: 1953176 Russian.
Strain 344 synthesizing an antibiotic complex was isolated after fusion of the protoplasts of Streptomyces monomycini producing monomycin and Streptomyces kanamyceticus producing kanamycin. The major component of the complex was identified with albofungin and the minor one …
Strain 344 synthesizing an antibiotic complex was isolated after fusion of the protoplasts of Streptomyces monomycini producing monomycin an …
Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.
Wu WS, Cheng WC, Cheng TR, Wong CH. Wu WS, et al. J Am Chem Soc. 2018 Feb 28;140(8):2752-2755. doi: 10.1021/jacs.7b13205. Epub 2018 Feb 13. J Am Chem Soc. 2018. PMID: 29411975
In combination with mass spectrometry and assays with moenomycin A and salicylanilide analogues (1-10) as reference inhibitors, we isolated four potent antibacterials confirmed to be benastatin derivatives (11-13) and albofungin (14). Compounds 11 and 14 were effective ant …
In combination with mass spectrometry and assays with moenomycin A and salicylanilide analogues (1-10) as reference inhibitors, we isolated …
Proteomining-Based Elucidation of Natural Product Biosynthetic Pathways in Streptomyces.
Linardi D, She W, Zhang Q, Yu Y, Qian PY, Lam H. Linardi D, et al. Front Microbiol. 2022 Jul 11;13:913756. doi: 10.3389/fmicb.2022.913756. eCollection 2022. Front Microbiol. 2022. PMID: 35898901 Free PMC article.
Among them, we independently re-discovered the type II PKS for albofungin production previously identified by genome mining and tedious heterologous expression experiments. ...
Among them, we independently re-discovered the type II PKS for albofungin production previously identified by genome mining and tedio …
24 results