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Modulation of sodium-coupled choline transporter CHT function in health and disease.
Ojiakor OA, Rylett RJ. Ojiakor OA, et al. Neurochem Int. 2020 Nov;140:104810. doi: 10.1016/j.neuint.2020.104810. Epub 2020 Aug 5. Neurochem Int. 2020. PMID: 32768485 Free article. Review.
Over the years, functionally-relevant CHT polymorphisms have been linked to a range of neurological and psychiatric disorders, including ADHD and depression; the impact of these mutations and the extent to which they alter cholinergic signaling have not been addressed full …
Over the years, functionally-relevant CHT polymorphisms have been linked to a range of neurological and psychiatric disorders, including …
Choline transporter gene variation is associated with attention-deficit hyperactivity disorder.
English BA, Hahn MK, Gizer IR, Mazei-Robison M, Steele A, Kurnik DM, Stein MA, Waldman ID, Blakely RD. English BA, et al. J Neurodev Disord. 2009 Dec;1(4):252-63. doi: 10.1007/s11689-009-9033-8. Epub 2009 Aug 28. J Neurodev Disord. 2009. PMID: 21547719 Free PMC article.
The neurotransmitter acetylcholine (ACh) plays a critical role in brain circuits mediating motor control, attention, learning and memory. Cholinergic dysfunction is associated with multiple brain disorders including Alzheimer's Disease, addiction, schizophrenia and Atte …
The neurotransmitter acetylcholine (ACh) plays a critical role in brain circuits mediating motor control, attention, learning and mem …
Array CGH analysis of a cohort of Russian patients with intellectual disability.
Kashevarova AA, Nazarenko LP, Skryabin NA, Salyukova OA, Chechetkina NN, Tolmacheva EN, Sazhenova EA, Magini P, Graziano C, Romeo G, Kučinskas V, Lebedev IN. Kashevarova AA, et al. Gene. 2014 Feb 15;536(1):145-50. doi: 10.1016/j.gene.2013.11.029. Epub 2013 Nov 27. Gene. 2014. PMID: 24291026
Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.
Berry AS, Demeter E, Sabhapathy S, English BA, Blakely RD, Sarter M, Lustig C. Berry AS, et al. J Cogn Neurosci. 2014 Sep;26(9):1981-91. doi: 10.1162/jocn_a_00607. Epub 2014 Mar 25. J Cogn Neurosci. 2014. PMID: 24666128 Free PMC article.
Both the passage of time and external distraction make it difficult to keep attention on the task at hand. We tested the hypothesis that time-on-task and external distraction pose independent challenges to attention and that the brain's cholinergic system selectivel …
Both the passage of time and external distraction make it difficult to keep attention on the task at hand. We tested the hypothesis t …
Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: relevance to neuropsychiatric disorders.
Santoro ML, Santos CM, Ota VK, Gadelha A, Stilhano RS, Diana MC, Silva PN, Spíndola LM, Melaragno MI, Bressan RA, Han SW, Abílio VC, Belangero SI. Santoro ML, et al. Psychiatry Res. 2014 Nov 30;219(3):674-9. doi: 10.1016/j.psychres.2014.05.034. Epub 2014 Jun 5. Psychiatry Res. 2014. PMID: 25041985
The spontaneously hypertensive rat (SHR) strain was shown to be a useful animal model to study several behavioral, pathophysiological and pharmacological aspects of schizophrenia and attention-deficit/hyperactivity disorder. To further understand the g …
The spontaneously hypertensive rat (SHR) strain was shown to be a useful animal model to study several behavioral, pathophysiological and ph …
Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine.
Dong Y, Dani JA, Blakely RD. Dong Y, et al. Biochem Pharmacol. 2013 Oct 15;86(8):1084-8. doi: 10.1016/j.bcp.2013.07.019. Epub 2013 Aug 9. Biochem Pharmacol. 2013. PMID: 23939187 Free PMC article.
The capacity for cholinergic signaling is dictated by the availability and activity of the presynaptic, high-affinity, choline transporter (CHT, SLC5A7) that acquires choline in an activity-dependent matter to sustain ACh synthesis. ...These findings reinforce a critical r …
The capacity for cholinergic signaling is dictated by the availability and activity of the presynaptic, high-affinity, choline transporter ( …