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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1942 1
1946 12
1947 9
1948 15
1949 11
1950 9
1951 14
1952 8
1953 20
1954 14
1955 20
1956 20
1957 32
1958 32
1959 29
1960 38
1961 36
1962 34
1963 42
1964 42
1965 42
1966 28
1967 27
1968 36
1969 38
1970 68
1971 286
1972 473
1973 545
1974 456
1975 358
1976 313
1977 316
1978 337
1979 317
1980 302
1981 299
1982 333
1983 319
1984 433
1985 409
1986 473
1987 446
1988 439
1989 536
1990 549
1991 538
1992 499
1993 541
1994 632
1995 562
1996 575
1997 577
1998 598
1999 690
2000 817
2001 929
2002 1022
2003 1063
2004 1145
2005 1303
2006 1465
2007 1542
2008 1501
2009 1529
2010 1689
2011 1884
2012 1934
2013 2046
2014 1949
2015 1924
2016 2012
2017 2057
2018 1909
2019 1900
2020 1901
2021 1841
2022 1407
2023 1300
2024 568

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48,372 results

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Page 1
Protein acylation: mechanisms, biological functions and therapeutic targets.
Shang S, Liu J, Hua F. Shang S, et al. Signal Transduct Target Ther. 2022 Dec 29;7(1):396. doi: 10.1038/s41392-022-01245-y. Signal Transduct Target Ther. 2022. PMID: 36577755 Free PMC article. Review.
Herein, we summarize the functional diversity and mechanisms of eight kinds of nonhistone protein acylations in the physiological processes and progression of several diseases. We also highlight the recent progress in the development of inhibitors for acyltransferase, deac …
Herein, we summarize the functional diversity and mechanisms of eight kinds of nonhistone protein acylations in the physiological pro …
Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification.
Fu Y, Yu J, Li F, Ge S. Fu Y, et al. J Exp Clin Cancer Res. 2022 Apr 15;41(1):144. doi: 10.1186/s13046-022-02338-w. J Exp Clin Cancer Res. 2022. PMID: 35428309 Free PMC article. Review.
Lysine acetylation is not discussed in detail in this review since it has been broadly investigated. We focus on the nine aforementioned novel lysine acylations beyond acetylation, which can be classified into two categories: histone acylations and nonhistone acy …
Lysine acetylation is not discussed in detail in this review since it has been broadly investigated. We focus on the nine aforementioned nov …
Linking chromatin acylation mark-defined proteome and genome in living cells.
Qin F, Li B, Wang H, Ma S, Li J, Liu S, Kong L, Zheng H, Zhu R, Han Y, Yang M, Li K, Ji X, Chen PR. Qin F, et al. Cell. 2023 Mar 2;186(5):1066-1085.e36. doi: 10.1016/j.cell.2023.02.007. Cell. 2023. PMID: 36868209
We herein developed a single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications and subsequent profiling of chromatinized proteome and genome defined by specific chromatin acylations in living cells. By leveraging the genetic code …
We herein developed a single-site-resolved multi-omics (SiTomics) strategy for systematic mapping of dynamic modifications and subsequent pr …
Chemical insights into flexizyme-mediated tRNA acylation.
Coronado JN, Ngo P, Anslyn EV, Ellington AD. Coronado JN, et al. Cell Chem Biol. 2022 Jul 21;29(7):1071-1112. doi: 10.1016/j.chembiol.2022.03.012. Epub 2022 Apr 11. Cell Chem Biol. 2022. PMID: 35413283 Free article. Review.
A critical step in repurposing the cellular translation machinery for the synthesis of polymeric products is the acylation of transfer RNA (tRNA) with unnatural monomers. Toward this goal, flexizymes, ribozymes capable of aminoacylation, have emerged as a uniquely adept to …
A critical step in repurposing the cellular translation machinery for the synthesis of polymeric products is the acylation of transfe …
An Expanding Repertoire of Protein Acylations.
Xu Y, Shi Z, Bao L. Xu Y, et al. Mol Cell Proteomics. 2022 Mar;21(3):100193. doi: 10.1016/j.mcpro.2022.100193. Epub 2022 Jan 6. Mol Cell Proteomics. 2022. PMID: 34999219 Free PMC article. Review.
Protein post-translational modifications play key roles in multiple cellular processes by allowing rapid reprogramming of individual protein functions. Acylation, one of the most important post-translational modifications, is involved in different physiological activities …
Protein post-translational modifications play key roles in multiple cellular processes by allowing rapid reprogramming of individual protein …
Dynamic Protein S-Acylation in Plants.
Zheng L, Liu P, Liu Q, Wang T, Dong J. Zheng L, et al. Int J Mol Sci. 2019 Jan 29;20(3):560. doi: 10.3390/ijms20030560. Int J Mol Sci. 2019. PMID: 30699892 Free PMC article. Review.
We summarize some proteins that have been shown experimentally to be S-acylated in plants. Two of these S-acylated proteins have been matched to the S-acyl transferase. More importantly, the first protein thioesterase with de-S-acylation activity has been ide …
We summarize some proteins that have been shown experimentally to be S-acylated in plants. Two of these S-acylated proteins ha …
Novel post-translational modifications in the kidneys for human health and diseases.
Xiang T, Zhao S, Wu Y, Li L, Fu P, Ma L. Xiang T, et al. Life Sci. 2022 Dec 15;311(Pt B):121188. doi: 10.1016/j.lfs.2022.121188. Epub 2022 Nov 12. Life Sci. 2022. PMID: 36375568 Review.
Short-chain fatty acids (SFCAs) exhibit diverse functions from kidneys to human health and diseases, and also could exert their roles in post-translational modifications (PTMs). Nowadays, novel short-chain lysine acylations derived from SFCAs have attracted more attentions …
Short-chain fatty acids (SFCAs) exhibit diverse functions from kidneys to human health and diseases, and also could exert their roles in pos …
Structure and Mechanism of DHHC Protein Acyltransferases.
Stix R, Lee CJ, Faraldo-Gómez JD, Banerjee A. Stix R, et al. J Mol Biol. 2020 Aug 21;432(18):4983-4998. doi: 10.1016/j.jmb.2020.05.023. Epub 2020 Jun 6. J Mol Biol. 2020. PMID: 32522557 Free PMC article. Review.
S-acylation, whereby a fatty acid chain is covalently linked to a cysteine residue by a thioester linkage, is the most prevalent kind of lipid modification of proteins. ...There has also been an increasing number of reports in the literature documenting the importance of S …
S-acylation, whereby a fatty acid chain is covalently linked to a cysteine residue by a thioester linkage, is the most prevalent kind …
Short-chain fatty acid, acylation and cardiovascular diseases.
Chen XF, Chen X, Tang X. Chen XF, et al. Clin Sci (Lond). 2020 Mar 27;134(6):657-676. doi: 10.1042/CS20200128. Clin Sci (Lond). 2020. PMID: 32219347 Review.
However, a growing body of study has implied that short-chain fatty acids (SCFAs: namely propionate, malonate, butyrate, 2-hydroxyisobutyrate (2-HIBA), beta-hydroxybutyrate, crotonate, succinate, and glutarate) and their cognate acylations (propionylation, malonylation, bu …
However, a growing body of study has implied that short-chain fatty acids (SCFAs: namely propionate, malonate, butyrate, 2-hydroxyisobutyrat …
Beyond histone acetylation-writing and erasing histone acylations.
Zhao S, Zhang X, Li H. Zhao S, et al. Curr Opin Struct Biol. 2018 Dec;53:169-177. doi: 10.1016/j.sbi.2018.10.001. Epub 2018 Nov 2. Curr Opin Struct Biol. 2018. PMID: 30391813 Review.
From a structural perspective, here we summarize the writers and erasers of histone acylations and explain the molecular basis of these enzymes catalyzing non-acetyl histone acylations with a focus on histone crotonylation and beta-hydroxybutyrylation. Histone ac …
From a structural perspective, here we summarize the writers and erasers of histone acylations and explain the molecular basis of the …
48,372 results
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