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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1993 2
1996 1
2000 2
2001 1
2002 1
2004 1
2006 1
2007 4
2008 1
2009 2
2010 2
2011 2
2012 3
2013 1
2014 1
2015 3
2018 2
2019 1
2020 3
2021 2
2022 1
2023 1
2024 2

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37 results

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Page 1
The redox stress hypothesis of aging.
Sohal RS, Orr WC. Sohal RS, et al. Free Radic Biol Med. 2012 Feb 1;52(3):539-555. doi: 10.1016/j.freeradbiomed.2011.10.445. Epub 2011 Oct 24. Free Radic Biol Med. 2012. PMID: 22080087 Free PMC article. Review.
Until relatively recently, ROS were considered to be potentially toxic by-products of aerobic metabolism, which, if not eliminated, may inflict structural damage on various macromolecules. Accrual of such damage over time was postulated to be responsible for the phy …
Until relatively recently, ROS were considered to be potentially toxic by-products of aerobic metabolism, which, if not eliminated, may infl …
Oxidative stress, caloric restriction, and aging.
Sohal RS, Weindruch R. Sohal RS, et al. Science. 1996 Jul 5;273(5271):59-63. doi: 10.1126/science.273.5271.59. Science. 1996. PMID: 8658196 Free PMC article. Review.
The amount of oxidative damage increases as an organism ages and is postulated to be a major causal factor of senescence. Support for this hypothesis includes the following observations: (i) Overexpression of antioxidative enzymes retards the age-related accrual of …
The amount of oxidative damage increases as an organism ages and is postulated to be a major causal factor of senescence. Support for …
Beyond Fever, Cough and Dyspnea: The Neurology of COVID-19.
Garg D, Srivastava AK, Dhamija RK. Garg D, et al. J Assoc Physicians India. 2020 Sep;68(9):62-66. J Assoc Physicians India. 2020. PMID: 32798347 Review.
Although the characteristic concern in patients with COVID-19 is acute respiratory distress, there is meteoric accrual of data on neurological involvement. Neurological manifestations in COVID-19 have staggering diversity, ranging from mild olfactory and gustatory percepti …
Although the characteristic concern in patients with COVID-19 is acute respiratory distress, there is meteoric accrual of data on neu …
The endocrine role of the skeleton: background and clinical evidence.
Schwetz V, Pieber T, Obermayer-Pietsch B. Schwetz V, et al. Eur J Endocrinol. 2012 Jun;166(6):959-67. doi: 10.1530/EJE-12-0030. Epub 2012 Mar 21. Eur J Endocrinol. 2012. PMID: 22436399 Review.
Based on the observation that diabetes, obesity, and hypogonadism influence bone metabolism, the existence of a feedback loop and a common regulation was postulated and an endocrine role ascribed to the skeleton. In the first part of this review, two pathways are described …
Based on the observation that diabetes, obesity, and hypogonadism influence bone metabolism, the existence of a feedback loop and a common r …
Burn injury and restoration of muscle function.
Klein GL. Klein GL. Bone. 2020 Mar;132:115194. doi: 10.1016/j.bone.2019.115194. Epub 2019 Dec 19. Bone. 2020. PMID: 31863962 Free PMC article. Clinical Trial.
A randomized controlled trial of a single dose of the bisphosphonate pamidronate within the first ten days of burn injury resulted in the prevention of resorptive bone loss and continuous bone accrual. Examining the muscle protein kinetics in pediatric burn patients enroll …
A randomized controlled trial of a single dose of the bisphosphonate pamidronate within the first ten days of burn injury resulted in the pr …
Calcitriol in the treatment of prostate cancer.
Beer TM, Myrthue A. Beer TM, et al. Anticancer Res. 2006 Jul-Aug;26(4A):2647-51. Anticancer Res. 2006. PMID: 16886675 Free article. Review.
These antineoplastic effects were observed at calcitriol concentrations substantially above the physiological range. While a number of mechanisms of action have been postulated, the induction of apoptosis and inhibition of proliferation have been most extensively reported. …
These antineoplastic effects were observed at calcitriol concentrations substantially above the physiological range. While a number of mecha …
PErsonalized TReatment for Endometrial Carcinoma (PETREC): study design and methods of a prospective Finnish multicenter trial.
Loukovaara M, Bützow R, Staff S, Mäenpää M, Faltinová M, Lassus H, Veijalainen O, Grönvall M, Vaalavirta L, Kuikka E, Haataja M, Urpilainen E, Simojoki M, Anttila M, Auranen A. Loukovaara M, et al. Int J Gynecol Cancer. 2023 Nov 6;33(11):1807-1811. doi: 10.1136/ijgc-2023-004939. Int J Gynecol Cancer. 2023. PMID: 37813479 Clinical Trial.
Early-stage high-risk p53abn and nonendometrioid carcinomas are postulated to gain benefits from chemoradiotherapy, as opposed to chemotherapy alone. ...SAMPLE SIZE: A total sample size of 294 patients (49 subjects in each treatment arm of the three subgroups intended for …
Early-stage high-risk p53abn and nonendometrioid carcinomas are postulated to gain benefits from chemoradiotherapy, as opposed to che …
Impact of apolipoprotein E on Alzheimer's disease.
Hauser PS, Ryan RO. Hauser PS, et al. Curr Alzheimer Res. 2013 Oct;10(8):809-17. doi: 10.2174/15672050113109990156. Curr Alzheimer Res. 2013. PMID: 23919769 Free PMC article. Review.
A tertiary structural feature distinguishing apoE4 from apoE2 and apoE3, termed domain interaction, is postulated to affect the conformation and orientation of its' two independently folded domains. This feature has the potential to influence apoE4's interaction with Abeta …
A tertiary structural feature distinguishing apoE4 from apoE2 and apoE3, termed domain interaction, is postulated to affect the confo …
Effects of adrenal steroids on the bone metabolism of children with congenital adrenal hyperplasia.
Lin-Su K, New MI. Lin-Su K, et al. Ann N Y Acad Sci. 2007 Nov;1117:345-51. doi: 10.1196/annals.1402.040. Ann N Y Acad Sci. 2007. PMID: 18056052 Review.
The primary treatment for patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is glucocorticoid replacement therapy, which at supraphysiologic levels can result in diminished bone accrual and lead to osteopenia and osteoporosis. Unli …
The primary treatment for patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is glucocorticoid repl …
Combined carboplatin and cisplatin. Limited prospects for dose intensification.
Waterhouse DM, Reynolds RK, Natale RB. Waterhouse DM, et al. Cancer. 1993 Jun 15;71(12):4060-6. doi: 10.1002/1097-0142(19930615)71:12<4060::aid-cncr2820711242>3.0.co;2-0. Cancer. 1993. PMID: 8508371 Review.
Early experience with combined platinum regimens, however, found myelosuppression, particularly severe thrombocytopenia, to be dose-limiting. It was postulated that a 2-day interval between carboplatin and cisplatin would allow for near complete clearance of the former bef …
Early experience with combined platinum regimens, however, found myelosuppression, particularly severe thrombocytopenia, to be dose-limiting …
37 results