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Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia.

O'Brien JM, Beal MA, Yauk CL, Marchetti F.

Toxicol Sci. 2016 Aug;152(2):363-71. doi: 10.1093/toxsci/kfw088. Epub 2016 May 13.


Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene.

Chepelev NL, Long AS, Bowers WJ, Gagné R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL.

Environ Mol Mutagen. 2016 Jun;57(5):350-63. doi: 10.1002/em.22020. Epub 2016 May 19.


Meta-analysis of transcriptomic responses as a means to identify pulmonary disease outcomes for engineered nanomaterials.

Nikota J, Williams A, Yauk CL, Wallin H, Vogel U, Halappanavar S.

Part Fibre Toxicol. 2016 May 11;13(1):25. doi: 10.1186/s12989-016-0137-5.


Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes.

Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, Halappanavar S.

Part Fibre Toxicol. 2016 Mar 15;13:15. doi: 10.1186/s12989-016-0125-9.


Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9.

Yauk CL, Buick JK, Williams A, Swartz CD, Recio L, Li HH, Fornace AJ Jr, Thomson EM, Aubrecht J.

Environ Mol Mutagen. 2016 May;57(4):243-60. doi: 10.1002/em.22004. Epub 2016 Mar 4.


Hepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS).

Dong H, Curran I, Williams A, Bondy G, Yauk CL, Wade MG.

Environ Toxicol Pharmacol. 2016 Jan;41:201-10. doi: 10.1016/j.etap.2015.12.009. Epub 2015 Dec 21.


BMDExpress Data Viewer - a visualization tool to analyze BMDExpress datasets.

Kuo B, Francina Webster A, Thomas RS, Yauk CL.

J Appl Toxicol. 2016 Aug;36(8):1048-59. doi: 10.1002/jat.3265. Epub 2015 Dec 15.


Adipogenic Mesenchymal Stromal Cells from Bone Marrow and Their Hematopoietic Supportive Role: Towards Understanding the Permissive Marrow Microenvironment in Acute Myeloid Leukemia.

Le Y, Fraineau S, Chandran P, Sabloff M, Brand M, Lavoie JR, Gagne R, Rosu-Myles M, Yauk CL, Richardson RB, Allan DS.

Stem Cell Rev. 2016 Apr;12(2):235-44. doi: 10.1007/s12015-015-9639-z.


The adverse outcome pathway (AOP) for chemical binding to tubulin in oocytes leading to aneuploid offspring.

Marchetti F, Massarotti A, Yauk CL, Pacchierotti F, Russo A.

Environ Mol Mutagen. 2016 Mar;57(2):87-113. doi: 10.1002/em.21986. Epub 2015 Nov 19. Review.


Carbon black nanoparticles induce biphasic gene expression changes associated with inflammatory responses in the lungs of C57BL/6 mice following a single intratracheal instillation.

Husain M, Kyjovska ZO, Bourdon-Lacombe J, Saber AT, Jensen KA, Jacobsen NR, Williams A, Wallin H, Halappanavar S, Vogel U, Yauk CL.

Toxicol Appl Pharmacol. 2015 Dec 15;289(3):573-88. doi: 10.1016/j.taap.2015.11.003. Epub 2015 Nov 10.


Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse.

Chepelev NL, Long AS, Williams A, Kuo B, Gagné R, Kennedy DA, Phillips DH, Arlt VM, White PA, Yauk CL.

Toxicol Sci. 2016 Jan;149(1):251-68. doi: 10.1093/toxsci/kfv232. Epub 2015 Oct 24.


Gene expression analysis of livers from female B6C3F1 mice exposed to carcinogenic and non-carcinogenic doses of furan, with or without bromodeoxyuridine (BrdU) treatment.

Webster AF, Williams A, Recio L, Yauk CL.

Genom Data. 2014 Jun 11;2:117-22. doi: 10.1016/j.gdata.2014.05.013. eCollection 2014 Dec.


Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing.

Beal MA, Gagné R, Williams A, Marchetti F, Yauk CL.

BMC Genomics. 2015 Oct 19;16:812. doi: 10.1186/s12864-015-2004-4.


A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells.

Williams A, Buick JK, Moffat I, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Data Brief. 2015 Aug 24;5:77-83. doi: 10.1016/j.dib.2015.08.013. eCollection 2015 Dec.


Comparative transcriptomic analyses to scrutinize the assumption that genotoxic PAHs exert effects via a common mode of action.

Labib S, Williams A, Guo CH, Leingartner K, Arlt VM, Schmeiser HH, Yauk CL, White PA, Halappanavar S.

Arch Toxicol. 2015 Sep 16. [Epub ahead of print]


Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues.

Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE.

Toxicol Sci. 2015 Dec;148(2):460-72. doi: 10.1093/toxsci/kfv195. Epub 2015 Sep 10.


Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD).

Webster AF, Chepelev N, Gagné R, Kuo B, Recio L, Williams A, Yauk CL.

PLoS One. 2015 Aug 27;10(8):e0136764. doi: 10.1371/journal.pone.0136764. eCollection 2015.


HPLC Measurement of the DNA Oxidation Biomarker, 8-oxo-7,8-dihydro-2'-deoxyguanosine, in Cultured Cells and Animal Tissues.

Chepelev NL, Kennedy DA, Gagné R, White T, Long AS, Yauk CL, White PA.

J Vis Exp. 2015 Aug 1;(102):e52697. doi: 10.3791/52697.


Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats.

Dong H, Gill S, Curran IH, Williams A, Kuo B, Wade MG, Yauk CL.

Arch Toxicol. 2016 Jun;90(6):1351-67. doi: 10.1007/s00204-015-1561-2. Epub 2015 Jul 21.


Dietary folic acid protects against genotoxicity in the red blood cells of mice.

MacFarlane AJ, Behan NA, Field MS, Williams A, Stover PJ, Yauk CL.

Mutat Res. 2015 Sep;779:105-11. doi: 10.1016/j.mrfmmm.2015.06.012. Epub 2015 Jun 29.

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