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Single-molecule PCR analysis of an unstable microsatellite for detecting mutations in sperm of mice exposed to chemical mutagens.

Beal MA, Rowan-Carroll A, Campbell C, Williams A, Somers CM, Marchetti F, Yauk CL.

Mutat Res. 2015 Mar 30;775:26-32. doi: 10.1016/j.mrfmmm.2015.03.010. [Epub ahead of print]


Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells.

Li HH, Hyduke DR, Chen R, Heard P, Yauk CL, Aubrecht J, Fornace AJ Jr.

Environ Mol Mutagen. 2015 Mar 2. doi: 10.1002/em.21941. [Epub ahead of print]


Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.

Buick JK, Moffat I, Williams A, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Environ Mol Mutagen. 2015 Mar 2. doi: 10.1002/em.21940. [Epub ahead of print]


Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease.

Poulsen SS, Saber AT, Mortensen A, Szarek J, Wu D, Williams A, Andersen O, Jacobsen NR, Yauk CL, Wallin H, Halappanavar S, Vogel U.

Toxicol Appl Pharmacol. 2015 Mar 15;283(3):210-22. doi: 10.1016/j.taap.2015.01.011. Epub 2015 Jan 22.


Time-dependent subcellular distribution and effects of carbon nanotubes in lungs of mice.

Købler C, Poulsen SS, Saber AT, Jacobsen NR, Wallin H, Yauk CL, Halappanavar S, Vogel U, Qvortrup K, Mølhave K.

PLoS One. 2015 Jan 23;10(1):e0116481. doi: 10.1371/journal.pone.0116481. eCollection 2015.


Integrating toxicogenomics into human health risk assessment: lessons learned from the benzo[a]pyrene case study.

Chepelev NL, Moffat ID, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Malik AI, Halappanavar S, Williams A, Yauk CL.

Crit Rev Toxicol. 2015 Jan;45(1):44-52. doi: 10.3109/10408444.2014.973935.


Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water.

Moffat I, Chepelev NL, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik AI, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL.

Crit Rev Toxicol. 2015 Jan;45(1):1-43. doi: 10.3109/10408444.2014.973934.


Sublinear response in lacZ mutant frequency of Muta Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.

O'Brien JM, Walker M, Sivathayalan A, Douglas GR, Yauk CL, Marchetti F.

Environ Mol Mutagen. 2015 Jan 17. doi: 10.1002/em.21932. [Epub ahead of print]


MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs.

Poulsen SS, Saber AT, Williams A, Andersen O, Købler C, Atluri R, Pozzebon ME, Mucelli SP, Simion M, Rickerby D, Mortensen A, Jackson P, Kyjovska ZO, Mølhave K, Jacobsen NR, Jensen KA, Yauk CL, Wallin H, Halappanavar S, Vogel U.

Toxicol Appl Pharmacol. 2015 Apr 1;284(1):16-32. doi: 10.1016/j.taap.2014.12.011. Epub 2014 Dec 29.


Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response.

Halappanavar S, Saber AT, Decan N, Jensen KA, Wu D, Jacobsen NR, Guo C, Rogowski J, Koponen IK, Levin M, Madsen AM, Atluri R, Snitka V, Birkedal RK, Rickerby D, Williams A, Wallin H, Yauk CL, Vogel U.

Environ Mol Mutagen. 2015 Mar;56(2):245-64. doi: 10.1002/em.21936. Epub 2014 Dec 11.


Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity.

Chepelev NL, Meek ME, Yauk CL.

J Appl Toxicol. 2014 Nov;34(11):1115-21. doi: 10.1002/jat.3071. Epub 2014 Sep 22.


Transgenic rodent assay for quantifying male germ cell mutant frequency.

O'Brien JM, Beal MA, Gingerich JD, Soper L, Douglas GR, Yauk CL, Marchetti F.

J Vis Exp. 2014 Aug 6;(90):e51576. doi: 10.3791/51576.


Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling.

Boucher JG, Husain M, Rowan-Carroll A, Williams A, Yauk CL, Atlas E.

Obesity (Silver Spring). 2014 Nov;22(11):2333-43. doi: 10.1002/oby.20848. Epub 2014 Jul 22.


Thyroid hormone response element half-site organization and its effect on thyroid hormone mediated transcription.

Paquette MA, Atlas E, Wade MG, Yauk CL.

PLoS One. 2014 Jun 27;9(6):e101155. doi: 10.1371/journal.pone.0101155. eCollection 2014.


Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease.

Saber AT, Jacobsen NR, Jackson P, Poulsen SS, Kyjovska ZO, Halappanavar S, Yauk CL, Wallin H, Vogel U.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Nov-Dec;6(6):517-31. doi: 10.1002/wnan.1279. Epub 2014 Jun 12.


Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver.

Webster AF, Williams A, Recio L, Yauk CL.

Toxicology. 2014 Sep 2;323:26-31. doi: 10.1016/j.tox.2014.06.002. Epub 2014 Jun 6.


Tris(1,3-dichloro-2-propyl) phosphate perturbs the expression of genes involved in immune response and lipid and steroid metabolism in chicken embryos.

Farhat A, Buick JK, Williams A, Yauk CL, O'Brien JM, Crump D, Williams KL, Chiu S, Kennedy SW.

Toxicol Appl Pharmacol. 2014 Mar 1;275(2):104-12. doi: 10.1016/j.taap.2013.12.020. Epub 2014 Jan 7.


Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells.

Søs Poulsen S, Jacobsen NR, Labib S, Wu D, Husain M, Williams A, Bøgelund JP, Andersen O, Købler C, Mølhave K, Kyjovska ZO, Saber AT, Wallin H, Yauk CL, Vogel U, Halappanavar S.

PLoS One. 2013 Nov 19;8(11):e80452. doi: 10.1371/journal.pone.0080452. eCollection 2013.


Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.

Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77. doi: 10.1016/j.taap.2013.10.019. Epub 2013 Oct 29.

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