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Results: 1 to 20 of 197

1.

Mono-anionic Phosphopeptides Produced by Unexpected Histidine Alkylation Exhibit High Plk1 Polo-box Domain-binding Affinities and Enhanced Antiproliferative Effects in HeLa Cells.

Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr.

Biopolymers. 2014 Oct 4. doi: 10.1002/bip.22569. [Epub ahead of print]

PMID:
25283071
[PubMed - as supplied by publisher]
2.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-109. doi: 10.1016/j.cell.2014.07.032.

PMID:
25171410
[PubMed - in process]
3.

Selective Mitogen Activated Protein Kinase Activity Sensors through the Application of Directionally Programmable D Domain Motifs.

Peterson LB, Yaffe MB, Imperiali B.

Biochemistry. 2014 Sep 16;53(36):5771-8. doi: 10.1021/bi500862c. Epub 2014 Sep 3.

PMID:
25153342
[PubMed - in process]
4.

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG Jr.

Cancer Cell. 2014 Aug 11;26(2):222-34. doi: 10.1016/j.ccr.2014.06.026.

PMID:
25117710
[PubMed - indexed for MEDLINE]
5.

A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways.

Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT.

Sci Signal. 2014 May 13;7(325):ra44. doi: 10.1126/scisignal.2005261.

PMID:
24825919
[PubMed - in process]
6.

Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.

Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH.

Cell Death Differ. 2014 Jun;21(6):854-63. doi: 10.1038/cdd.2014.8. Epub 2014 Feb 7.

PMID:
24510127
[PubMed - in process]
7.

Death of a Titan.

Sudol M, Yaffe MB.

Sci Signal. 2013 Dec 17;6(306):eg6. doi: 10.1126/scisignal.2004914.

PMID:
24345678
[PubMed - indexed for MEDLINE]
8.

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB.

Cell Rep. 2013 Nov 27;5(4):868-77. doi: 10.1016/j.celrep.2013.10.025. Epub 2013 Nov 14.

PMID:
24239348
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.

Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP.

J Biol Chem. 2013 Nov 29;288(48):34968-80. doi: 10.1074/jbc.M113.523266. Epub 2013 Oct 15.

PMID:
24129568
[PubMed - indexed for MEDLINE]
10.

Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.

Qian WJ, Park JE, Lim D, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR Jr.

Chem Biol. 2013 Oct 24;20(10):1255-64. doi: 10.1016/j.chembiol.2013.09.005. Epub 2013 Oct 10.

PMID:
24120332
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.

Reinhardt HC, Yaffe MB.

Nat Rev Mol Cell Biol. 2013 Sep;14(9):563-80. doi: 10.1038/nrm3640. Review.

PMID:
23969844
[PubMed - indexed for MEDLINE]
12.

mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.

Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.

PMID:
23888043
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB.

Nature. 2013 Jun 13;498(7453):246-50. doi: 10.1038/nature12147. Epub 2013 Jun 2.

PMID:
23728299
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM.

Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20.

PMID:
23685806
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A.

Science. 2013 May 17;340(6134):871-5. doi: 10.1126/science.1235822. Epub 2013 Apr 11.

PMID:
23579499
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment.

Yaffe MB.

Sci Signal. 2013 Apr 2;6(269):pe13. doi: 10.1126/scisignal.2003684.

PMID:
23550209
[PubMed - indexed for MEDLINE]
17.

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.

Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK.

Bioorg Med Chem. 2013 May 1;21(9):2623-34. doi: 10.1016/j.bmc.2013.02.020. Epub 2013 Feb 27.

PMID:
23498919
[PubMed - indexed for MEDLINE]
18.

Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.

Weingeist DM, Ge J, Wood DK, Mutamba JT, Huang Q, Rowland EA, Yaffe MB, Floyd S, Engelward BP.

Cell Cycle. 2013 Mar 15;12(6):907-15. doi: 10.4161/cc.23880. Epub 2013 Feb 19.

PMID:
23422001
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

2012: Signaling breakthroughs of the year.

Yaffe MB, Gough NR.

Sci Signal. 2013 Jan 1;6(256):eg1. doi: 10.1126/scisignal.2003881. No abstract available.

PMID:
23281367
[PubMed - indexed for MEDLINE]
Free Article
20.

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.

Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T.

EMBO J. 2012 Oct 17;31(20):3961-75. doi: 10.1038/emboj.2012.236. Epub 2012 Aug 21.

PMID:
22909821
[PubMed - indexed for MEDLINE]
Free PMC Article

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