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Did you mean ywhah (101 results)?
The role of YWHAZ in cancer: A maze of opportunities and challenges.
Gan Y, Ye F, He XX. Gan Y, et al. J Cancer. 2020 Feb 3;11(8):2252-2264. doi: 10.7150/jca.41316. eCollection 2020. J Cancer. 2020. PMID: 32127952 Free PMC article. Review.
Additionally, YWHAZ may be a potential biomarker of diagnosis, prognosis and chemoresistance in several cancers. ...In this review, we perform literature and bioinformatics analysis to reveal the oncogenic role and molecular mechanism of YWHAZ in cancer, and discuss …
Additionally, YWHAZ may be a potential biomarker of diagnosis, prognosis and chemoresistance in several cancers. ...In this review, w …
YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.
Wan RP, Liu ZG, Huang XF, Kwan P, Li YP, Qu XC, Ye XG, Chen FY, Zhang DW, He MF, Wang J, Mao YL, Qiao JD. Wan RP, et al. Hum Mol Genet. 2023 Jan 13;32(3):462-472. doi: 10.1093/hmg/ddac210. Hum Mol Genet. 2023. PMID: 36001342 Free PMC article.
Cognitive defects and mushroom body morphological abnormalities were observed in YWHAZ c.147A > T knockin flies. The YWHAZ knockdown flies also manifested serious cognitive defects with hyperactivity behaviors, which is consistent with the clinical features. Our …
Cognitive defects and mushroom body morphological abnormalities were observed in YWHAZ c.147A > T knockin flies. The YWHAZ …
YWHAZ promotes ovarian cancer metastasis by modulating glycolysis.
Shi J, Ye J, Fei H, Jiang SH, Wu ZY, Chen YP, Zhang LW, Yang XM. Shi J, et al. Oncol Rep. 2019 Feb;41(2):1101-1112. doi: 10.3892/or.2018.6920. Epub 2018 Dec 7. Oncol Rep. 2019. PMID: 30535456
High YWHAZ expression was found to be associated with TNM stage and metastasis-free prognosis of ovarian cancer patients. ...Cell migration was also suppressed by YWHAZ silencing. Furthermore, using an in vivo metastatic model, we found that YWHAZ silence als …
High YWHAZ expression was found to be associated with TNM stage and metastasis-free prognosis of ovarian cancer patients. ...Cell mig …
YWHAZ interacts with DAAM1 to promote cell migration in breast cancer.
Mei J, Liu Y, Yu X, Hao L, Ma T, Zhan Q, Zhang Y, Zhu Y. Mei J, et al. Cell Death Discov. 2021 Aug 27;7(1):221. doi: 10.1038/s41420-021-00609-7. Cell Death Discov. 2021. PMID: 34453038 Free PMC article.
Moreover, miR-613 directly targeted both YWHAZ and DAAM1, contributing to inhibiting BrCa cells migration via blocking the complex of YWHAZ-DAAM1. To sum up, these data reveal that YWHAZ regulates DAAM1 activation, and the YWHAZ-DAAM1 complex is direct …
Moreover, miR-613 directly targeted both YWHAZ and DAAM1, contributing to inhibiting BrCa cells migration via blocking the complex of …
YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer.
Kim S, Park JY, Lee HW, Bae SU, Kim KE, Byun SJ, Seo I. Kim S, et al. Sci Rep. 2023 Aug 9;13(1):12902. doi: 10.1038/s41598-023-39488-6. Sci Rep. 2023. PMID: 37558778 Free PMC article.
The expression stability of 14 housekeeping genes (HKGs; ACTB, B2M, G6PD, GAPDH, GUSB, HMBS, HPRT1, IPO8, PGK1, PPIA, TBP, TFRC, UBC, and YWHAZ) after irradiation was evaluated using RefFinder using raw quantification cycle (Cq) values obtained from samples before and afte …
The expression stability of 14 housekeeping genes (HKGs; ACTB, B2M, G6PD, GAPDH, GUSB, HMBS, HPRT1, IPO8, PGK1, PPIA, TBP, TFRC, UBC, and …
High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
Cao F, Jiang Y, Chang L, Du H, Chang D, Pan C, Huang X, Yu D, Zhang M, Fan Y, Bian X, Li K. Cao F, et al. Cell Death Dis. 2023 Jul 14;14(7):431. doi: 10.1038/s41419-023-05951-5. Cell Death Dis. 2023. PMID: 37452033 Free PMC article.
The metastasis-promoting role of YWHAZ was further validated in human pancreatic cancer cells. Overexpression of YWHAZ resulted in more aggressive metastatic phenotypes in vitro and a shorter survival rate in vivo by modulating epithelial-to-mesenchymal transition. …
The metastasis-promoting role of YWHAZ was further validated in human pancreatic cancer cells. Overexpression of YWHAZ resulte …
YWHAZ amplification/overexpression defines aggressive bladder cancer and contributes to chemo-/radio-resistance by suppressing caspase-mediated apoptosis.
Yu CC, Li CF, Chen IH, Lai MT, Lin ZJ, Korla PK, Chai CY, Ko G, Chen CM, Hwang T, Lee SC, Sheu JJ. Yu CC, et al. J Pathol. 2019 Aug;248(4):476-487. doi: 10.1002/path.5274. Epub 2019 Apr 29. J Pathol. 2019. PMID: 30945298 Free PMC article.
Ectopic expression of YWHAZ in bladder cells with low endogenous YWHAZ levels boosted cell resistance to doxorubicin and cisplatin, as well as to ionizing radiation. ...Treatments based on anti-YWHAZ strategies may thus be beneficial for UCUB patients overexp …
Ectopic expression of YWHAZ in bladder cells with low endogenous YWHAZ levels boosted cell resistance to doxorubicin and cispl …
A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
Popov IK, Hiatt SM, Whalen S, Keren B, Ruivenkamp C, van Haeringen A, Chen MJ, Cooper GM, Korf BR, Chang C. Popov IK, et al. Front Physiol. 2019 Apr 8;10:388. doi: 10.3389/fphys.2019.00388. eCollection 2019. Front Physiol. 2019. PMID: 31024343 Free PMC article.
We show that compared with wild type YWHAZ, the S230W variant induces severe embryonic defects when ectopically expressed in early Xenopus embryos. The S230W variant also rescues the defects induced by a dominant negative FGF receptor more efficiently and enhances Raf-stim …
We show that compared with wild type YWHAZ, the S230W variant induces severe embryonic defects when ectopically expressed in early Xe …
Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish.
Antón-Galindo E, Dalla Vecchia E, Orlandi JG, Castro G, Gualda EJ, Young AMJ, Guasch-Piqueras M, Arenas C, Herrera-Úbeda C, Garcia-Fernàndez J, Aguado F, Loza-Alvarez P, Cormand B, Norton WHJ, Fernàndez-Castillo N. Antón-Galindo E, et al. Mol Psychiatry. 2022 Sep;27(9):3739-3748. doi: 10.1038/s41380-022-01577-9. Epub 2022 May 2. Mol Psychiatry. 2022. PMID: 35501409
Here, we have used zebrafish to investigate the mechanisms by which YWHAZ contributes to neurodevelopmental disorders. We observed that ywhaz expression was pan-neuronal during developmental stages and restricted to Purkinje cells in the adult cerebellum, cells that …
Here, we have used zebrafish to investigate the mechanisms by which YWHAZ contributes to neurodevelopmental disorders. We observed th …
669 results