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Results: 1 to 20 of 23

1.

Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.

Mizutani S, Yoshida T, Zhao X, Nimer SD, Taniwaki M, Okuda T.

Br J Haematol. 2015 May 26. doi: 10.1111/bjh.13499. [Epub ahead of print]

PMID:
26010396
2.

Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.

Hu H, Owens EA, Su H, Yan L, Levitz A, Zhao X, Henary M, Zheng YG.

J Med Chem. 2015 Feb 12;58(3):1228-43. doi: 10.1021/jm501452j. Epub 2015 Jan 21.

PMID:
25559100
3.

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL.

Cell Rep. 2014 Dec 11;9(5):1841-55. doi: 10.1016/j.celrep.2014.11.004. Epub 2014 Dec 4.

4.

Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro.

Han X, Li R, Zhang W, Yang X, Wheeler CG, Friedman GK, Province P, Ding Q, You Z, Fathallah-Shaykh HM, Gillespie GY, Zhao X, King PH, Nabors LB.

J Neurooncol. 2014 May;118(1):61-72. doi: 10.1007/s11060-014-1419-0. Epub 2014 Mar 25.

5.

Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.

Yan L, Yan C, Qian K, Su H, Kofsky-Wofford SA, Lee WC, Zhao X, Ho MC, Ivanov I, Zheng YG.

J Med Chem. 2014 Mar 27;57(6):2611-22. doi: 10.1021/jm401884z. Epub 2014 Mar 6.

6.

PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.

Vu LP, Perna F, Wang L, Voza F, Figueroa ME, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer SD.

Cell Rep. 2013 Dec 26;5(6):1625-38. doi: 10.1016/j.celrep.2013.11.025. Epub 2013 Dec 12.

7.

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.

Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung YR, Kuscu C, Hricik T, Ndiaye-Lobry D, Lafave LM, Koche R, Shih AH, Guryanova OA, Kim E, Li S, Pandey S, Shin JY, Telis L, Liu J, Bhatt PK, Monette S, Zhao X, Mason CE, Park CY, Bernstein BE, Aifantis I, Levine RL.

J Exp Med. 2013 Nov 18;210(12):2641-59. doi: 10.1084/jem.20131141. Epub 2013 Nov 11.

8.

Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD.

Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199.

9.

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.

Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, Pandey S, Patel JP, Chung YR, Koche R, Perna F, Zhao X, Taylor JE, Park CY, Carroll M, Melnick A, Nimer SD, Jaffe JD, Aifantis I, Bernstein BE, Levine RL.

Cancer Cell. 2012 Aug 14;22(2):180-93. doi: 10.1016/j.ccr.2012.06.032.

10.

Visible-light-promoted C-C bond cleavage: photocatalytic generation of iminium ions and amino radicals.

Cai S, Zhao X, Wang X, Liu Q, Li Z, Wang DZ.

Angew Chem Int Ed Engl. 2012 Aug 6;51(32):8050-3. doi: 10.1002/anie.201202880. Epub 2012 Jul 3. No abstract available.

PMID:
22760950
11.

PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.

Shia WJ, Okumura AJ, Yan M, Sarkeshik A, Lo MC, Matsuura S, Komeno Y, Zhao X, Nimer SD, Yates JR 3rd, Zhang DE.

Blood. 2012 May 24;119(21):4953-62. doi: 10.1182/blood-2011-04-347476. Epub 2012 Apr 12.

12.

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD.

Blood. 2011 Dec 15;118(25):6544-52. doi: 10.1182/blood-2010-11-317909. Epub 2011 Oct 19.

13.

Gold-catalyzed [3+2] cycloaddition/hydrolytic Michael addition/retro-aldol reactions of propargylic esters tethered to cyclohexadienones.

Cai S, Liu Z, Zhang W, Zhao X, Wang DZ.

Angew Chem Int Ed Engl. 2011 Nov 18;50(47):11133-7. doi: 10.1002/anie.201104028. Epub 2011 Sep 29. No abstract available.

PMID:
21960469
14.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Gomes DaGama EM, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross SS, Pillarsetty N, Ku T, Lewis JS, Larson SM, Levine R, Erdjument-Bromage H, Guzman ML, Nimer SD, Melnick A, Neckers L, Chiosis G.

Nat Chem Biol. 2011 Sep 25;7(11):818-26. doi: 10.1038/nchembio.670.

15.

Different optical properties between human hepatocellular carcinoma tissues and non-tumorous hepatic tissues in vitro.

Yu Y, Xiao C, Chen K, Zheng J, Zhang J, Zhao X, Xue X.

J Huazhong Univ Sci Technolog Med Sci. 2011 Aug;31(4):515-9. doi: 10.1007/s11596-011-0482-4. Epub 2011 Aug 7.

PMID:
21823014
16.

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.

Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD.

Science. 2011 Aug 5;333(6043):765-9. doi: 10.1126/science.1201662. Epub 2011 Jul 14.

17.

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, He C, Ibrahim S, Beran M, Zavadil J, Nimer SD, Melnick A, Godley LA, Aifantis I, Levine RL.

Cancer Cell. 2011 Jul 12;20(1):11-24. doi: 10.1016/j.ccr.2011.06.001. Epub 2011 Jun 30.

18.

The mef/elf4 transcription factor fine tunes the DNA damage response.

Sashida G, Bae N, Di Giandomenico S, Asai T, Gurvich N, Bazzoli E, Liu Y, Huang G, Zhao X, Menendez S, Nimer SD.

Cancer Res. 2011 Jul 15;71(14):4857-65. doi: 10.1158/0008-5472.CAN-11-0455. Epub 2011 May 26.

19.

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.

Liu F, Zhao X, Perna F, Wang L, Koppikar P, Abdel-Wahab O, Harr MW, Levine RL, Xu H, Tefferi A, Deblasio A, Hatlen M, Menendez S, Nimer SD.

Cancer Cell. 2011 Feb 15;19(2):283-94. doi: 10.1016/j.ccr.2010.12.020.

20.

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.

Perna F, Gurvich N, Hoya-Arias R, Abdel-Wahab O, Levine RL, Asai T, Voza F, Menendez S, Wang L, Liu F, Zhao X, Nimer SD.

Blood. 2010 Oct 14;116(15):2812-21. doi: 10.1182/blood-2010-02-270611. Epub 2010 Jun 28.

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