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Items: 5


Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS.

Wu R, Wang H, Xia X, Zhou H, Liu C, Castro M, Xu Z.

Antioxid Redox Signal. 2009 Jul;11(7):1523-34. doi: 10.1089/ARS.2009.2618.


A construct with fluorescent indicators for conditional expression of miRNA.

Qiu L, Wang H, Xia X, Zhou H, Xu Z.

BMC Biotechnol. 2008 Oct 7;8:77. doi: 10.1186/1472-6750-8-77.


Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression.

Wang H, Ghosh A, Baigude H, Yang CS, Qiu L, Xia X, Zhou H, Rana TM, Xu Z.

J Biol Chem. 2008 Jun 6;283(23):15845-52. doi: 10.1074/jbc.M800834200. Epub 2008 Mar 26.


Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

Xia X, Zhou H, Huang Y, Xu Z.

Neurobiol Dis. 2006 Sep;23(3):578-86. Epub 2006 Jul 20.


Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.

Ding H, Schwarz DS, Keene A, Affar el B, Fenton L, Xia X, Shi Y, Zamore PD, Xu Z.

Aging Cell. 2003 Aug;2(4):209-17.


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