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Results: 1 to 20 of 176

1.

Autophagy and checkpoints for intracellular pathogen defense.

Paulus GL, Xavier RJ.

Curr Opin Gastroenterol. 2014 Nov 11. [Epub ahead of print]

PMID:
25394238
[PubMed - as supplied by publisher]
2.

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.

Buffen K, Oosting M, Quintin J, Ng A, Kleinnijenhuis J, Kumar V, van de Vosse E, Wijmenga C, van Crevel R, Oosterwijk E, Grotenhuis AJ, Vermeulen SH, Kiemeney LA, van de Veerdonk FL, Chamilos G, Xavier RJ, van der Meer JW, Netea MG, Joosten LA.

PLoS Pathog. 2014 Oct 30;10(10):e1004485. doi: 10.1371/journal.ppat.1004485. eCollection 2014 Oct.

PMID:
25356988
[PubMed - in process]
Free PMC Article
3.

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.

Liao J, Jijon HB, Kim IR, Goel G, Doan A, Sokol H, Bauer H, Herrmann BG, Lassen KG, Xavier RJ.

PLoS One. 2014 Sep 30;9(9):e108777. doi: 10.1371/journal.pone.0108777. eCollection 2014.

PMID:
25268627
[PubMed - in process]
Free PMC Article
4.

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.

Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, Anderson DG, Hacohen N, Regev A, Feng G, Sharp PA, Zhang F.

Cell. 2014 Oct 9;159(2):440-55. doi: 10.1016/j.cell.2014.09.014. Epub 2014 Sep 25.

PMID:
25263330
[PubMed - in process]
5.

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

Saeed S, Quintin J, Kerstens HH, Rao NA, Aghajanirefah A, Matarese F, Cheng SC, Ratter J, Berentsen K, van der Ent MA, Sharifi N, Janssen-Megens EM, Ter Huurne M, Mandoli A, van Schaik T, Ng A, Burden F, Downes K, Frontini M, Kumar V, Giamarellos-Bourboulis EJ, Ouwehand WH, van der Meer JW, Joosten LA, Wijmenga C, Martens JH, Xavier RJ, Logie C, Netea MG, Stunnenberg HG.

Science. 2014 Sep 26;345(6204):1251086. doi: 10.1126/science.1251086.

PMID:
25258085
[PubMed - indexed for MEDLINE]
6.

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG.

Science. 2014 Sep 26;345(6204):1250684. doi: 10.1126/science.1250684.

PMID:
25258083
[PubMed - indexed for MEDLINE]
7.

Transmembrane Adaptor Protein PAG/CBP Is Involved in both Positive and Negative Regulation of Mast Cell Signaling.

Draberova L, Bugajev V, Potuckova L, Halova I, Bambouskova M, Polakovicova I, Xavier RJ, Seed B, Draber P.

Mol Cell Biol. 2014 Dec 1;34(23):4285-300. doi: 10.1128/MCB.00983-14. Epub 2014 Sep 22.

PMID:
25246632
[PubMed - in process]
8.

Small-molecule control of cytokine function: new opportunities for treating immune disorders.

Sundberg TB, Xavier RJ, Schreiber SL, Shamji AF.

Curr Opin Chem Biol. 2014 Sep 12;23C:23-30. doi: 10.1016/j.cbpa.2014.08.013. [Epub ahead of print] Review.

PMID:
25222143
[PubMed - as supplied by publisher]
Free Article
9.

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG.

Nat Commun. 2014 Sep 8;5:4675. doi: 10.1038/ncomms5675.

PMID:
25197941
[PubMed - in process]
10.

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE.

Nat Biotechnol. 2014 Sep 3. doi: 10.1038/nbt.3026. [Epub ahead of print]

PMID:
25184501
[PubMed - as supplied by publisher]
11.

Multivariate inference of pathway activity in host immunity and response to therapeutics.

Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ.

Nucleic Acids Res. 2014;42(16):10288-306. doi: 10.1093/nar/gku722. Epub 2014 Aug 21.

PMID:
25147207
[PubMed - in process]
Free Article
12.

An alteration in ATG16L1 stability in Crohn disease.

Lassen KG, Xavier RJ.

Autophagy. 2014 Oct 1;10(10):1858-60. doi: 10.4161/auto.29963. Epub 2014 Aug 12.

PMID:
25136803
[PubMed - in process]
13.

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

Sundberg TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B, Gagnon J, O'Connell DJ, Narayan K, Dančík V, Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, Shamji AF.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73. doi: 10.1073/pnas.1412308111. Epub 2014 Aug 11.

PMID:
25114223
[PubMed - in process]
Free PMC Article
14.

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.

Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA.

J Clin Invest. 2014 Aug 1;124(8):3617-33. doi: 10.1172/JCI75436. Epub 2014 Jul 8.

PMID:
25003194
[PubMed - in process]
Free PMC Article
15.

Coinfection. Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.

Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW.

Science. 2014 Aug 1;345(6196):573-7. doi: 10.1126/science.1254517. Epub 2014 Jun 26.

PMID:
24968940
[PubMed - indexed for MEDLINE]
16.

Inflammatory bowel disease as a model for translating the microbiome.

Huttenhower C, Kostic AD, Xavier RJ.

Immunity. 2014 Jun 19;40(6):843-54. doi: 10.1016/j.immuni.2014.05.013. Review.

PMID:
24950204
[PubMed - indexed for MEDLINE]
17.

SLCO3A1, a Novel Crohn's Disease-Associated Gene, Regulates NF-κB Activity and Associates with Intestinal Perforation.

Wei SC, Tan YY, Weng MT, Lai LC, Hsiao JH, Chuang EY, Shun CT, Wu DC, Kao AW, Chuang CS, Ni YH, Shieh MJ, Tung CC, Chen Y, Wang CY, Xavier RJ, Podolsky DK, Wong JM.

PLoS One. 2014 Jun 19;9(6):e100515. doi: 10.1371/journal.pone.0100515. eCollection 2014.

PMID:
24945726
[PubMed - in process]
Free PMC Article
18.

Dectin-1-Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages.

Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM.

J Infect Dis. 2014 Dec 1;210(11):1844-54. doi: 10.1093/infdis/jiu290. Epub 2014 May 19.

PMID:
24842831
[PubMed - in process]
19.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12.

PMID:
24821797
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W.

Cancer Immunol Res. 2013 Dec;1(6):426-37. doi: 10.1158/2326-6066.CIR-13-0065. Epub 2013 Oct 7.

PMID:
24778134
[PubMed - in process]

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