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Results: 1 to 20 of 41


Systems approach to the study of brain damage in the very preterm newborn.

Leviton A, Gressens P, Wolkenhauer O, Dammann O.

Front Syst Neurosci. 2015 Apr 14;9:58. doi: 10.3389/fnsys.2015.00058. eCollection 2015.


Annotation-based feature extraction from sets of SBML models.

Alm R, Waltemath D, Wolfien M, Wolkenhauer O, Henkel R.

J Biomed Semantics. 2015 Apr 15;6:20. doi: 10.1186/s13326-015-0014-4. eCollection 2015.


Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants.

Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, Wolkenhauer O, Jaster R, Kunz M, Tiedge M, Ibrahim S, Fuellen G, Köhling R.

PLoS One. 2015 Apr 8;10(4):e0123863. doi: 10.1371/journal.pone.0123863. eCollection 2015.


Combining computational models, semantic annotations and simulation experiments in a graph database.

Henkel R, Wolkenhauer O, Waltemath D.

Database (Oxford). 2015 Mar 8;2015. pii: bau130. doi: 10.1093/database/bau130. Print 2015.


miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy.

Bhattacharya A, Schmitz U, Raatz Y, Schönherr M, Kottek T, Schauer M, Franz S, Saalbach A, Anderegg U, Wolkenhauer O, Schadendorf D, Simon JC, Magin T, Vera J, Kunz M.

Oncotarget. 2015 Feb 20;6(5):2966-80.


Systems Epidemiology: What's in a Name?

Dammann O, Gray P, Gressens P, Wolkenhauer O, Leviton A.

Online J Public Health Inform. 2014 Dec 15;6(3):e198. doi: 10.5210/ojphi.v6i3.5571. eCollection 2014.


Anti-inflammatory effects of reactive oxygen species - a multi-valued logical model validated by formal concept analysis.

Wollbold J, Jaster R, Müller S, Rateitschak K, Wolkenhauer O.

BMC Syst Biol. 2014 Sep 24;8:101. doi: 10.1186/s12918-014-0101-7.


Enabling multiscale modeling in systems medicine.

Wolkenhauer O, Auffray C, Brass O, Clairambault J, Deutsch A, Drasdo D, Gervasio F, Preziosi L, Maini P, Marciniak-Czochra A, Kossow C, Kuepfer L, Rateitschak K, Ramis-Conde I, Ribba B, Schuppert A, Smallwood R, Stamatakos G, Winter F, Byrne H.

Genome Med. 2014 Mar 21;6(3):21. doi: 10.1186/gm538. eCollection 2014. No abstract available.


Cooperative gene regulation by microRNA pairs and their identification using a computational workflow.

Schmitz U, Lai X, Winter F, Wolkenhauer O, Vera J, Gupta SK.

Nucleic Acids Res. 2014 Jul;42(12):7539-52. doi: 10.1093/nar/gku465. Epub 2014 May 29.


Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching.

Moeller M, Hirose M, Mueller S, Roolf C, Baltrusch S, Ibrahim S, Junghanss C, Wolkenhauer O, Jaster R, Köhling R, Kunz M, Tiedge M, Schofield PN, Fuellen G.

Aging Cell. 2014 Aug;13(4):729-38. doi: 10.1111/acel.12226. Epub 2014 May 23.


Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice.

Müller S, Kaiser H, Krüger B, Fitzner B, Lange F, Bock CN, Nizze H, Ibrahim SM, Fuellen G, Wolkenhauer O, Jaster R.

PLoS One. 2014 Apr 10;9(4):e94494. doi: 10.1371/journal.pone.0094494. eCollection 2014.


Why model?

Wolkenhauer O.

Front Physiol. 2014 Jan 28;5:21. doi: 10.3389/fphys.2014.00021. eCollection 2014. Review.


The role of theory and modeling in medical research.

Wolkenhauer O.

Front Physiol. 2013 Dec 19;4:377. doi: 10.3389/fphys.2013.00377. eCollection 2013. No abstract available.


A systems' biology approach to study microRNA-mediated gene regulatory networks.

Lai X, Bhattacharya A, Schmitz U, Kunz M, Vera J, Wolkenhauer O.

Biomed Res Int. 2013;2013:703849. doi: 10.1155/2013/703849. Epub 2013 Nov 17.


Phosphoglycerate mutases function as reverse regulated isoenzymes in Synechococcus elongatus PCC 7942.

Jablonsky J, Hagemann M, Schwarz D, Wolkenhauer O.

PLoS One. 2013;8(3):e58281. doi: 10.1371/journal.pone.0058281. Epub 2013 Mar 6.


Integrative modelling of pH-dependent enzyme activity and transcriptomic regulation of the acetone-butanol-ethanol fermentation of Clostridium acetobutylicum in continuous culture.

Millat T, Janssen H, Bahl H, Fischer RJ, Wolkenhauer O.

Microb Biotechnol. 2013 Sep;6(5):526-39. doi: 10.1111/1751-7915.12033. Epub 2013 Jan 21.


Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT.

Liebal UW, Millat T, Marles-Wright J, Lewis RJ, Wolkenhauer O.

BMC Syst Biol. 2013 Jan 15;7:3. doi: 10.1186/1752-0509-7-3.


Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells.

Rateitschak K, Winter F, Lange F, Jaster R, Wolkenhauer O.

PLoS Comput Biol. 2012;8(12):e1002815. doi: 10.1371/journal.pcbi.1002815. Epub 2012 Dec 20.


Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach.

Lange F, Rateitschak K, Kossow C, Wolkenhauer O, Jaster R.

World J Gastroenterol. 2012 Nov 21;18(43):6226-34. doi: 10.3748/wjg.v18.i43.6226.


Integration in action.

Green S, Wolkenhauer O.

EMBO Rep. 2012 Sep;13(9):769-71. doi: 10.1038/embor.2012.121. Epub 2012 Aug 17.

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