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Results: 1 to 20 of 185

1.

Diversity-Oriented Synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.

Lukens AK, Heidebrecht RW Jr, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, Wirth DF.

J Infect Dis. 2014 Oct 21. pii: jiu565. [Epub ahead of print]

PMID:
25336726
[PubMed - as supplied by publisher]
2.

Clonal outbreak of Plasmodium falciparum in eastern Panama.

Obaldia N 3rd, Baro NK, Calzada JE, Santamaria AM, Daniels R, Wong W, Chang HH, Hamilton EJ, Arevalo-Herrera M, Herrera S, Wirth DF, Hartl DL, Marti M, Volkman SK.

J Infect Dis. 2014 Oct 21. pii: jiu575. [Epub ahead of print]

PMID:
25336725
[PubMed - as supplied by publisher]
3.

Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers.

Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM.

Am J Hematol. 2014 Sep 27. doi: 10.1002/ajh.23860. [Epub ahead of print]

PMID:
25263455
[PubMed - as supplied by publisher]
4.

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.

Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL.

J Med Chem. 2014 Oct 23;57(20):8496-502. doi: 10.1021/jm500994n. Epub 2014 Oct 13.

PMID:
25211597
[PubMed - in process]
5.

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, Saralaya R, Bharath S, Viswanath P, Mukherjee K, Bandodkar B, Srivastava A, Panduga V, Reddy J, Prabhakar KR, Sinha A, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Magistrado PA, Lukens AK, Wirth DF, Waterson D, Balasubramanian V, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK, Ramachandran S.

J Med Chem. 2014 Jul 10;57(13):5702-13. doi: 10.1021/jm500535j. Epub 2014 Jun 24.

PMID:
24914738
[PubMed - indexed for MEDLINE]
6.

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

Ross LS, Gamo FJ, Lafuente-Monasterio MJ, Singh OM, Rowland P, Wiegand RC, Wirth DF.

J Biol Chem. 2014 Jun 27;289(26):17980-95. doi: 10.1074/jbc.M114.558353. Epub 2014 Apr 29.

PMID:
24782313
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia.

Mharakurwa S, Daniels R, Scott A, Wirth DF, Thuma P, Volkman SK.

Malar J. 2014 Mar 12;13:89. doi: 10.1186/1475-2875-13-89.

PMID:
24618119
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

An adjustable gas-mixing device to increase feasibility of in vitro culture of plasmodium falciparum parasites in the field.

Bei AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D, Mboup S, Wirth DF.

PLoS One. 2014 Mar 6;9(3):e90928. doi: 10.1371/journal.pone.0090928. eCollection 2014.

PMID:
24603696
[PubMed - in process]
Free PMC Article
9.

On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs.

Karunaweera ND, Galappaththy GN, Wirth DF.

Malar J. 2014 Feb 18;13:59. doi: 10.1186/1475-2875-13-59. Review.

PMID:
24548783
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission.

Gunawardena S, Ferreira MU, Kapilananda GM, Wirth DF, Karunaweera ND.

Parasitology. 2014 Jun;141(7):880-90. doi: 10.1017/S0031182013002278. Epub 2014 Feb 14.

PMID:
24533989
[PubMed - in process]
11.

Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal.

Ndiaye D, Dieye B, Ndiaye YD, Van Tyne D, Daniels R, Bei AK, Mbaye A, Valim C, Lukens A, Mboup S, Ndir O, Wirth DF, Volkman S.

Int J Parasitol Drugs Drug Resist. 2013 Aug 12;3:135-42. doi: 10.1016/j.ijpddr.2013.07.001. eCollection 2013 Dec.

PMID:
24533303
[PubMed]
Free PMC Article
12.

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.

Deme AB, Park DJ, Bei AK, Sarr O, Badiane AS, Gueye Pel H, Ahouidi A, Ndir O, Mboup S, Wirth DF, Ndiaye D, Volkman SK.

Malar J. 2014 Jan 29;13:34. doi: 10.1186/1475-2875-13-34.

PMID:
24472178
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.

Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. doi: 10.1073/pnas.1320886110. Epub 2013 Dec 31.

PMID:
24381157
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal.

Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D.

Malar J. 2013 Dec 6;12:441. doi: 10.1186/1475-2875-12-441.

PMID:
24314037
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Malaria life cycle intensifies both natural selection and random genetic drift.

Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20129-34. doi: 10.1073/pnas.1319857110. Epub 2013 Nov 20.

PMID:
24259712
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.

Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2838-47. doi: 10.1073/pnas.1306097110. Epub 2013 Jul 8.

PMID:
23836641
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.

Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK.

PLoS One. 2013 Apr 4;8(4):e60780. doi: 10.1371/journal.pone.0060780. Print 2013.

PMID:
23593309
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.

Van Tyne D, Uboldi AD, Healer J, Cowman AF, Wirth DF.

Antimicrob Agents Chemother. 2013 Jul;57(7):2937-41. doi: 10.1128/AAC.02574-12. Epub 2013 Apr 15.

PMID:
23587962
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene.

Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT.

Cell Host Microbe. 2012 Dec 13;12(6):739-50. doi: 10.1016/j.chom.2012.11.004.

PMID:
23245319
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.

Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13052-7. doi: 10.1073/pnas.1210585109. Epub 2012 Jul 23.

PMID:
22826220
[PubMed - indexed for MEDLINE]
Free PMC Article

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