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Results: 1 to 20 of 182

1.

Diversity-Oriented Synthesis-Facilitated Medicinal Chemistry: Towards the Development of Novel Antimalarial Agents.

Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee MD, Masi D, Mulrooney C, Mercier M, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL.

J Med Chem. 2014 Sep 11. [Epub ahead of print]

PMID:
25211597
[PubMed - as supplied by publisher]
2.

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, Saralaya R, Bharath S, Viswanath P, Mukherjee K, Bandodkar B, Srivastava A, Panduga V, Reddy J, Prabhakar KR, Sinha A, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Magistrado PA, Lukens AK, Wirth DF, Waterson D, Balasubramanian V, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK, Ramachandran S.

J Med Chem. 2014 Jul 10;57(13):5702-13. doi: 10.1021/jm500535j. Epub 2014 Jun 24.

PMID:
24914738
[PubMed - indexed for MEDLINE]
3.

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

Ross LS, Gamo FJ, Lafuente-Monasterio MJ, Singh OM, Rowland P, Wiegand RC, Wirth DF.

J Biol Chem. 2014 Jun 27;289(26):17980-95. doi: 10.1074/jbc.M114.558353. Epub 2014 Apr 29.

PMID:
24782313
[PubMed - in process]
Free PMC Article
4.

Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia.

Mharakurwa S, Daniels R, Scott A, Wirth DF, Thuma P, Volkman SK.

Malar J. 2014 Mar 12;13:89. doi: 10.1186/1475-2875-13-89.

PMID:
24618119
[PubMed - in process]
Free PMC Article
5.

An adjustable gas-mixing device to increase feasibility of in vitro culture of plasmodium falciparum parasites in the field.

Bei AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D, Mboup S, Wirth DF.

PLoS One. 2014 Mar 6;9(3):e90928. doi: 10.1371/journal.pone.0090928. eCollection 2014.

PMID:
24603696
[PubMed - in process]
Free PMC Article
6.

On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs.

Karunaweera ND, Galappaththy GN, Wirth DF.

Malar J. 2014 Feb 18;13:59. doi: 10.1186/1475-2875-13-59.

PMID:
24548783
[PubMed - in process]
Free PMC Article
7.

The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission.

Gunawardena S, Ferreira MU, Kapilananda GM, Wirth DF, Karunaweera ND.

Parasitology. 2014 Jun;141(7):880-90. doi: 10.1017/S0031182013002278. Epub 2014 Feb 14.

PMID:
24533989
[PubMed - in process]
8.

Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal.

Ndiaye D, Dieye B, Ndiaye YD, Van Tyne D, Daniels R, Bei AK, Mbaye A, Valim C, Lukens A, Mboup S, Ndir O, Wirth DF, Volkman S.

Int J Parasitol Drugs Drug Resist. 2013 Aug 12;3:135-42. doi: 10.1016/j.ijpddr.2013.07.001. eCollection 2013 Dec.

PMID:
24533303
[PubMed]
Free PMC Article
9.

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.

Deme AB, Park DJ, Bei AK, Sarr O, Badiane AS, Gueye Pel H, Ahouidi A, Ndir O, Mboup S, Wirth DF, Ndiaye D, Volkman SK.

Malar J. 2014 Jan 29;13:34. doi: 10.1186/1475-2875-13-34.

PMID:
24472178
[PubMed - in process]
Free PMC Article
10.

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.

Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. doi: 10.1073/pnas.1320886110. Epub 2013 Dec 31.

PMID:
24381157
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal.

Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D.

Malar J. 2013 Dec 6;12:441. doi: 10.1186/1475-2875-12-441.

PMID:
24314037
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Malaria life cycle intensifies both natural selection and random genetic drift.

Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20129-34. doi: 10.1073/pnas.1319857110. Epub 2013 Nov 20.

PMID:
24259712
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.

Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2838-47. doi: 10.1073/pnas.1306097110. Epub 2013 Jul 8.

PMID:
23836641
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.

Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK.

PLoS One. 2013 Apr 4;8(4):e60780. doi: 10.1371/journal.pone.0060780. Print 2013.

PMID:
23593309
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.

Van Tyne D, Uboldi AD, Healer J, Cowman AF, Wirth DF.

Antimicrob Agents Chemother. 2013 Jul;57(7):2937-41. doi: 10.1128/AAC.02574-12. Epub 2013 Apr 15.

PMID:
23587962
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene.

Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT.

Cell Host Microbe. 2012 Dec 13;12(6):739-50. doi: 10.1016/j.chom.2012.11.004.

PMID:
23245319
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.

Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13052-7. doi: 10.1073/pnas.1210585109. Epub 2012 Jul 23.

PMID:
22826220
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.

Chang HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D, Ndir O, Mboup S, Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Mol Biol Evol. 2012 Nov;29(11):3427-39. doi: 10.1093/molbev/mss161. Epub 2012 Jun 24.

PMID:
22734050
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal.

Ly O, Gueye PE, Deme AB, Dieng T, Badiane AS, Ahouidi AD, Diallo M, Bei AK, Wirth DF, Mboup S, Sarr O.

Parasitol Res. 2012 Oct;111(4):1541-6. Epub 2012 Jun 17.

PMID:
22706959
[PubMed - indexed for MEDLINE]
20.

SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites.

Amambua-Ngwa A, Park DJ, Volkman SK, Barnes KG, Bei AK, Lukens AK, Sene P, Van Tyne D, Ndiaye D, Wirth DF, Conway DJ, Neafsey DE, Schaffner SF.

Mol Biol Evol. 2012 Nov;29(11):3249-53. doi: 10.1093/molbev/mss151. Epub 2012 Jun 11.

PMID:
22688945
[PubMed - indexed for MEDLINE]
Free PMC Article

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