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Results: 1 to 20 of 189

1.

COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data.

Galinsky K, Valim C, Salmier A, de Thoisy B, Musset L, Legrand E, Faust A, Baniecki ML, Ndiaye D, Daniels RF, Hartl DL, Sabeti PC, Wirth DF, Volkman SK, Neafsey DE.

Malar J. 2015 Jan 19;14(1):4. [Epub ahead of print]

PMID:
25599890
[PubMed - as supplied by publisher]
Free Article
2.

Plasmodium falciparum gene expression measured directly from tissue during human infection.

Van Tyne D, Tan Y, Daily JP, Kamiza S, Seydel K, Taylor T, Mesirov JP, Wirth DF, Milner DA Jr.

Genome Med. 2014 Nov 29;6(11):110. doi: 10.1186/s13073-014-0110-6. eCollection 2014.

PMID:
25520756
[PubMed]
Free PMC Article
3.

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria.

Herman JD, Rice DP, Ribacke U, Silterra J, Deik AA, Moss EL, Broadbent KM, Neafsey DE, Desai MM, Clish CB, Mazitschek R, Wirth DF.

Genome Biol. 2014;15(11):511.

PMID:
25395010
[PubMed - in process]
Free PMC Article
4.

Immune characterization of Plasmodium falciparum parasites with a shared genetic signature in a region of decreasing transmission.

Bei AK, Diouf A, Miura K, Larremore DB, Ribacke U, Tullo G, Moss EL, Neafsey DE, Daniels RF, Zeituni AE, Nosamiefan I, Volkman SK, Ahouidi AD, Ndiaye D, Dieye T, Mboup S, Buckee CO, Long CA, Wirth DF.

Infect Immun. 2015 Jan;83(1):276-85. doi: 10.1128/IAI.01979-14. Epub 2014 Nov 3.

PMID:
25368109
[PubMed - indexed for MEDLINE]
5.

Diversity-Oriented Synthesis Probe Targets Plasmodium falciparum Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors.

Lukens AK, Heidebrecht RW Jr, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, Wirth DF.

J Infect Dis. 2014 Oct 21. pii: jiu565. [Epub ahead of print]

PMID:
25336726
[PubMed - as supplied by publisher]
6.

Clonal Outbreak of Plasmodium falciparum Infection in Eastern Panama.

Obaldia N 3rd, Baro NK, Calzada JE, Santamaria AM, Daniels R, Wong W, Chang HH, Hamilton EJ, Arevalo-Herrera M, Herrera S, Wirth DF, Hartl DL, Marti M, Volkman SK.

J Infect Dis. 2014 Oct 21. pii: jiu575. [Epub ahead of print]

PMID:
25336725
[PubMed - as supplied by publisher]
7.

Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers.

Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM.

Am J Hematol. 2015 Jan;90(1):31-6. doi: 10.1002/ajh.23860. Epub 2014 Oct 18.

PMID:
25263455
[PubMed - in process]
8.

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.

Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL.

J Med Chem. 2014 Oct 23;57(20):8496-502. doi: 10.1021/jm500994n. Epub 2014 Oct 13.

PMID:
25211597
[PubMed - in process]
9.

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, Saralaya R, Bharath S, Viswanath P, Mukherjee K, Bandodkar B, Srivastava A, Panduga V, Reddy J, Prabhakar KR, Sinha A, Jiménez-Díaz MB, Martínez MS, Angulo-Barturen I, Ferrer S, Sanz LM, Gamo FJ, Duffy S, Avery VM, Magistrado PA, Lukens AK, Wirth DF, Waterson D, Balasubramanian V, Iyer PS, Narayanan S, Hosagrahara V, Sambandamurthy VK, Ramachandran S.

J Med Chem. 2014 Jul 10;57(13):5702-13. doi: 10.1021/jm500535j. Epub 2014 Jun 24.

PMID:
24914738
[PubMed - indexed for MEDLINE]
10.

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

Ross LS, Gamo FJ, Lafuente-Monasterio MJ, Singh OM, Rowland P, Wiegand RC, Wirth DF.

J Biol Chem. 2014 Jun 27;289(26):17980-95. doi: 10.1074/jbc.M114.558353. Epub 2014 Apr 29.

PMID:
24782313
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia.

Mharakurwa S, Daniels R, Scott A, Wirth DF, Thuma P, Volkman SK.

Malar J. 2014 Mar 12;13:89. doi: 10.1186/1475-2875-13-89.

PMID:
24618119
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

An adjustable gas-mixing device to increase feasibility of in vitro culture of Plasmodium falciparum parasites in the field.

Bei AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D, Mboup S, Wirth DF.

PLoS One. 2014 Mar 6;9(3):e90928. doi: 10.1371/journal.pone.0090928. eCollection 2014.

PMID:
24603696
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs.

Karunaweera ND, Galappaththy GN, Wirth DF.

Malar J. 2014 Feb 18;13:59. doi: 10.1186/1475-2875-13-59. Review.

PMID:
24548783
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission.

Gunawardena S, Ferreira MU, Kapilananda GM, Wirth DF, Karunaweera ND.

Parasitology. 2014 Jun;141(7):880-90. doi: 10.1017/S0031182013002278. Epub 2014 Feb 14.

PMID:
24533989
[PubMed - indexed for MEDLINE]
15.

Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal.

Ndiaye D, Dieye B, Ndiaye YD, Van Tyne D, Daniels R, Bei AK, Mbaye A, Valim C, Lukens A, Mboup S, Ndir O, Wirth DF, Volkman S.

Int J Parasitol Drugs Drug Resist. 2013 Aug 12;3:135-42. doi: 10.1016/j.ijpddr.2013.07.001. eCollection 2013 Dec.

PMID:
24533303
[PubMed]
Free PMC Article
16.

Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.

Deme AB, Park DJ, Bei AK, Sarr O, Badiane AS, Gueye Pel H, Ahouidi A, Ndir O, Mboup S, Wirth DF, Ndiaye D, Volkman SK.

Malar J. 2014 Jan 29;13:34. doi: 10.1186/1475-2875-13-34.

PMID:
24472178
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.

Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. doi: 10.1073/pnas.1320886110. Epub 2013 Dec 31.

PMID:
24381157
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal.

Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D.

Malar J. 2013 Dec 6;12:441. doi: 10.1186/1475-2875-12-441.

PMID:
24314037
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Malaria life cycle intensifies both natural selection and random genetic drift.

Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20129-34. doi: 10.1073/pnas.1319857110. Epub 2013 Nov 20.

PMID:
24259712
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.

Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2838-47. doi: 10.1073/pnas.1306097110. Epub 2013 Jul 8.

PMID:
23836641
[PubMed - indexed for MEDLINE]
Free PMC Article
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