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Items: 1 to 20 of 308

1.

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.

Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S.

Science. 2016 Jan 28. pii: aad7974. [Epub ahead of print]

PMID:
26822609
2.

Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2-/- (C57BL/6) Mice.

Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, Kagan V, Tyurin V, Ferris RL, Zhang X, Li S, Greenberger JS.

Radiat Res. 2016 Jan 20. [Epub ahead of print]

PMID:
26789701
3.

Antioxidant Approaches to Management of Ionizing Irradiation Injury.

Greenberger J, Kagan V, Bayir H, Wipf P, Epperly M.

Antioxidants (Basel). 2015 Jan 23;4(1):82-101. doi: 10.3390/antiox4010082.

4.

Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.

Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P.

ACS Med Chem Lett. 2015 Oct 23;6(12):1225-30. doi: 10.1021/acsmedchemlett.5b00364. eCollection 2015 Dec 10.

PMID:
26713109
5.

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR.

J Biomol Screen. 2015 Nov 4. pii: 1087057115615518. [Epub ahead of print]

PMID:
26538432
6.

Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells.

Wu S, Guo Z, Hopkins CD, Wei N, Chu E, Wipf P, Schmitz JC.

Oncotarget. 2015 Dec 1;6(38):40866-79. doi: 10.18632/oncotarget.5885.

7.

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats.

Javadov S, Jang S, Rodriguez-Reyes N, Rodriguez-Zayas AE, Soto Hernandez J, Krainz T, Wipf P, Frontera W.

Oncotarget. 2015 Nov 24;6(37):39469-81. doi: 10.18632/oncotarget.5783.

8.

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines.

Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR.

Assay Drug Dev Technol. 2015 Sep;13(7):356-76. doi: 10.1089/adt.2015.663.

PMID:
26317883
9.

Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ.

Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

PMID:
26236050
10.

Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells.

Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4828-33. doi: 10.1016/j.bmcl.2015.06.073. Epub 2015 Jun 26.

PMID:
26159482
11.

Exploring the structure-activity relationships of ABCC2 modulators using a screening approach.

Wissel G, Kudryavtsev P, Ghemtio L, Tammela P, Wipf P, Yliperttula M, Finel M, Urtti A, Kidron H, Xhaard H.

Bioorg Med Chem. 2015 Jul 1;23(13):3513-25. doi: 10.1016/j.bmc.2015.04.029. Epub 2015 Apr 17.

PMID:
25935289
12.

Ring-strain-enabled reaction discovery: new heterocycles from bicyclo[1.1.0]butanes.

Walczak MA, Krainz T, Wipf P.

Acc Chem Res. 2015 Apr 21;48(4):1149-58. doi: 10.1021/ar500437h. Epub 2015 Mar 16.

PMID:
25775119
13.

Heat shock protein defenses in the neocortex and allocortex of the telencephalon.

Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK.

Neurobiol Aging. 2015 May;36(5):1924-37. doi: 10.1016/j.neurobiolaging.2015.02.011. Epub 2015 Feb 18.

PMID:
25771395
14.

SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest.

Tandon M, Salamoun JM, Carder EJ, Farber E, Xu S, Deng F, Tang H, Wipf P, Wang QJ.

PLoS One. 2015 Mar 6;10(3):e0119346. doi: 10.1371/journal.pone.0119346. eCollection 2015.

15.

Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.

George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS, Wipf P.

Bioorg Med Chem. 2015 Jun 15;23(12):2810-8. doi: 10.1016/j.bmc.2015.01.043. Epub 2015 Jan 31.

PMID:
25703307
16.

Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.

Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK.

J Neurochem. 2015 Jun;133(6):780-94. doi: 10.1111/jnc.13041. Epub 2015 Mar 5.

PMID:
25640060
17.

The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak.

Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. Epub 2014 Dec 30.

PMID:
25582599
18.
19.

Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.

Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S.

J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016/j.yjmcc.2014.10.009. Epub 2014 Oct 23.

20.

Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target.

Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL.

Bioorg Med Chem. 2014 Nov 15;22(22):6490-502.

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