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Items: 1 to 20 of 115


Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte.

Winslow RL, Walker MA, Greenstein JL.

Wiley Interdiscip Rev Syst Biol Med. 2015 Nov 12. doi: 10.1002/wsbm.1322. [Epub ahead of print] Review.


On the Adjacency Matrix of RyR2 Cluster Structures.

Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004521. doi: 10.1371/journal.pcbi.1004521. eCollection 2015 Nov.


Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2015 Nov;88:29-38. doi: 10.1016/j.yjmcc.2015.09.011. Epub 2015 Sep 23.


Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart.

Foteinou PT, Greenstein JL, Winslow RL.

Biophys J. 2015 Aug 18;109(4):838-49. doi: 10.1016/j.bpj.2015.06.064.


Computing network-based features from physiological time series: application to sepsis detection.

Santaniello S, Granite SJ, Sarma SV, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:3825-6. doi: 10.1109/EMBC.2014.6944457.


Superresolution modeling of calcium release in the heart.

Walker MA, Williams GS, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL.

Biophys J. 2014 Dec 16;107(12):3018-29. doi: 10.1016/j.bpj.2014.11.003.


Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart.

Greenstein JL, Foteinou PT, Hashambhoy-Ramsay YL, Winslow RL.

Front Pharmacol. 2014 Apr 3;5:60. doi: 10.3389/fphar.2014.00060. eCollection 2014. Review.


Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders.

Winslow RL.

Front Physiol. 2014 Mar 28;5:107. doi: 10.3389/fphys.2014.00107. eCollection 2014. No abstract available.


An integrated mitochondrial ROS production and scavenging model: implications for heart failure.

Gauthier LD, Greenstein JL, O'Rourke B, Winslow RL.

Biophys J. 2013 Dec 17;105(12):2832-42. doi: 10.1016/j.bpj.2013.11.007.


A computational model of reactive oxygen species and redox balance in cardiac mitochondria.

Gauthier LD, Greenstein JL, Cortassa S, O'Rourke B, Winslow RL.

Biophys J. 2013 Aug 20;105(4):1045-56. doi: 10.1016/j.bpj.2013.07.006.


Extinguishing the sparks.

Winslow RL, Greenstein JL.

Biophys J. 2013 May 21;104(10):2115-7. doi: 10.1016/j.bpj.2013.04.010. No abstract available.


Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure.

Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA, Tomaselli GF.

Circ Arrhythm Electrophysiol. 2013 Jun;6(3):546-54. doi: 10.1161/CIRCEP.113.000400. Epub 2013 May 6.


Integrating mitochondrial energetics, redox and ROS metabolic networks: a two-compartment model.

Kembro JM, Aon MA, Winslow RL, O'Rourke B, Cortassa S.

Biophys J. 2013 Jan 22;104(2):332-43. doi: 10.1016/j.bpj.2012.11.3808.


Computational medicine: translating models to clinical care.

Winslow RL, Trayanova N, Geman D, Miller MI.

Sci Transl Med. 2012 Oct 31;4(158):158rv11. doi: 10.1126/scitranslmed.3003528.


Toward an integrative computational model of the Guinea pig cardiac myocyte.

Gauthier LD, Greenstein JL, Winslow RL.

Front Physiol. 2012 Jul 5;3:244. doi: 10.3389/fphys.2012.00244. eCollection 2012.


Dynamics of matrix-free Ca2+ in cardiac mitochondria: two components of Ca2+ uptake and role of phosphate buffering.

Wei AC, Liu T, Winslow RL, O'Rourke B.

J Gen Physiol. 2012 Jun;139(6):465-78. doi: 10.1085/jgp.201210784.


Ontological labels for automated location of anatomical shape differences.

Steinert-Threlkeld S, Ardekani S, Mejino JL, Detwiler LT, Brinkley JF, Halle M, Kikinis R, Winslow RL, Miller MI, Ratnanather JT.

J Biomed Inform. 2012 Jun;45(3):522-7. doi: 10.1016/j.jbi.2012.02.013. Epub 2012 Apr 3.


Metabolic control analysis applied to mitochondrial networks.

Cortassa S, Aon MA, O'Rourke B, Winslow RL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4673-6. doi: 10.1109/IEMBS.2011.6091157.


CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte.

Hashambhoy YL, Winslow RL, Greenstein JL.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4665-8. doi: 10.1109/IEMBS.2011.6091155.


Model interactions: 'It is the simple, which is so difficult'.

Kohl P, Hunter PJ, Winslow RL.

Prog Biophys Mol Biol. 2011 Oct;107(1):1-3. doi: 10.1016/j.pbiomolbio.2011.07.003. Epub 2011 Jul 13. No abstract available.

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