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Results: 19

1.

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.

Maio N, Singh A, Uhrigshardt H, Saxena N, Tong WH, Rouault TA.

Cell Metab. 2014 Mar 4;19(3):445-57. doi: 10.1016/j.cmet.2014.01.015.

PMID:
24606901
[PubMed - in process]
2.

Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle.

Crooks DR, Natarajan TG, Jeong SY, Chen C, Park SY, Huang H, Ghosh MC, Tong WH, Haller RG, Wu C, Rouault TA.

Hum Mol Genet. 2014 Jan 1;23(1):24-39. doi: 10.1093/hmg/ddt393. Epub 2013 Aug 13.

PMID:
23943793
[PubMed - in process]
3.

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA.

Cell Metab. 2013 Feb 5;17(2):271-81. doi: 10.1016/j.cmet.2012.12.016.

PMID:
23395173
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tissue specificity of a human mitochondrial disease: differentiation-enhanced mis-splicing of the Fe-S scaffold gene ISCU renders patient cells more sensitive to oxidative stress in ISCU myopathy.

Crooks DR, Jeong SY, Tong WH, Ghosh MC, Olivierre H, Haller RG, Rouault TA.

J Biol Chem. 2012 Nov 23;287(48):40119-30. doi: 10.1074/jbc.M112.418889. Epub 2012 Oct 3.

PMID:
23035118
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Mutations in iron-sulfur cluster scaffold genes NFU1 and BOLA3 cause a fatal deficiency of multiple respiratory chain and 2-oxoacid dehydrogenase enzymes.

Cameron JM, Janer A, Levandovskiy V, Mackay N, Rouault TA, Tong WH, Ogilvie I, Shoubridge EA, Robinson BH.

Am J Hum Genet. 2011 Oct 7;89(4):486-95. doi: 10.1016/j.ajhg.2011.08.011. Epub 2011 Sep 22.

PMID:
21944046
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.

Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, Romero VV, Sougrat R, Vaulont S, Viollet B, Kim YS, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan WM, Rouault TA.

Cancer Cell. 2011 Sep 13;20(3):315-27. doi: 10.1016/j.ccr.2011.07.018.

PMID:
21907923
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Iron control of erythroid development by a novel aconitase-associated regulatory pathway.

Bullock GC, Delehanty LL, Talbot AL, Gonias SL, Tong WH, Rouault TA, Dewar B, Macdonald JM, Chruma JJ, Goldfarb AN.

Blood. 2010 Jul 8;116(1):97-108. doi: 10.1182/blood-2009-10-251496. Epub 2010 Apr 20.

PMID:
20407036
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.

Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA.

Blood. 2010 Jan 28;115(4):860-9. doi: 10.1182/blood-2009-09-243105. Epub 2009 Nov 25.

PMID:
19965627
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Tangled up in red: intertwining of the heme and iron-sulfur cluster biogenesis pathways.

Rouault TA, Tong WH.

Cell Metab. 2009 Aug;10(2):80-1. doi: 10.1016/j.cmet.2009.07.007.

PMID:
19656484
[PubMed - indexed for MEDLINE]
Free Article
10.

Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis.

Shi Y, Ghosh MC, Tong WH, Rouault TA.

Hum Mol Genet. 2009 Aug 15;18(16):3014-25. doi: 10.1093/hmg/ddp239. Epub 2009 May 18.

PMID:
19454487
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.

Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12028-33. doi: 10.1073/pnas.0805361105. Epub 2008 Aug 6.

PMID:
18685102
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Iron-sulfur cluster biogenesis and human disease.

Rouault TA, Tong WH.

Trends Genet. 2008 Aug;24(8):398-407. doi: 10.1016/j.tig.2008.05.008. Epub 2008 Jul 5. Review.

PMID:
18606475
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.

Mochel F, Knight MA, Tong WH, Hernandez D, Ayyad K, Taivassalo T, Andersen PM, Singleton A, Rouault TA, Fischbeck KH, Haller RG.

Am J Hum Genet. 2008 Mar;82(3):652-60. doi: 10.1016/j.ajhg.2007.12.012. Epub 2008 Feb 14.

PMID:
18304497
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis.

Tong WH, Rouault TA.

Biometals. 2007 Jun;20(3-4):549-64. Epub 2007 Jan 5. Review.

PMID:
17205209
[PubMed - indexed for MEDLINE]
15.

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.

Li K, Tong WH, Hughes RM, Rouault TA.

J Biol Chem. 2006 May 5;281(18):12344-51. Epub 2006 Mar 9.

PMID:
16527810
[PubMed - indexed for MEDLINE]
Free Article
16.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.

Tong WH, Rouault TA.

Cell Metab. 2006 Mar;3(3):199-210.

PMID:
16517407
[PubMed - indexed for MEDLINE]
Free Article
17.

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.

Smith SR, Ghosh MC, Ollivierre-Wilson H, Hang Tong W, Rouault TA.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):283-7. Epub 2006 Feb 15.

PMID:
16480904
[PubMed - indexed for MEDLINE]
18.

Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis.

Rouault TA, Tong WH.

Nat Rev Mol Cell Biol. 2005 Apr;6(4):345-51. Review.

PMID:
15803140
[PubMed - indexed for MEDLINE]
19.

Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster.

Tong WH, Jameson GN, Huynh BH, Rouault TA.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9762-7. Epub 2003 Jul 28.

PMID:
12886008
[PubMed - indexed for MEDLINE]
Free PMC Article

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