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Results: 1 to 20 of 118


SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

Glerup S, Olsen D, Vaegter CB, Gustafsen C, Sjoegaard SS, Hermey G, Kjolby M, Molgaard S, Ulrichsen M, Boggild S, Skeldal S, Fjorback AN, Nyengaard JR, Jacobsen J, Bender D, Bjarkam CR, Sørensen ES, Füchtbauer EM, Eichele G, Madsen P, Willnow TE, Petersen CM, Nykjaer A.

Neuron. 2014 Jun 4;82(5):1074-87. doi: 10.1016/j.neuron.2014.04.022.


Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

Carlo AS, Nykjaer A, Willnow TE.

J Mol Med (Berl). 2014 Sep;92(9):905-11. doi: 10.1007/s00109-014-1152-3. Epub 2014 May 18. Review.


LRP2 mediates folate uptake in the developing neural tube.

Kur E, Mecklenburg N, Cabrera RM, Willnow TE, Hammes A.

J Cell Sci. 2014 May 15;127(Pt 10):2261-8. doi: 10.1242/jcs.140145. Epub 2014 Mar 17.


Apolipoprotein E receptor pathways in Alzheimer disease.

Schmidt V, Carlo AS, Willnow TE.

Wiley Interdiscip Rev Syst Biol Med. 2014 May-Jun;6(3):255-70. doi: 10.1002/wsbm.1262. Epub 2014 Mar 6. Review.


Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.

Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Füchtbauer EM, Füchtbauer A, Holtzman DM, Takagi J, Willnow TE.

Sci Transl Med. 2014 Feb 12;6(223):223ra20. doi: 10.1126/scitranslmed.3007747.


Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.

Kooij G, Kopplin K, Blasig R, Stuiver M, Koning N, Goverse G, van der Pol SM, van Het Hof B, Gollasch M, Drexhage JA, Reijerkerk A, Meij IC, Mebius R, Willnow TE, Müller D, Blasig IE, de Vries HE.

Acta Neuropathol. 2014 Aug;128(2):267-77. doi: 10.1007/s00401-013-1227-1. Epub 2013 Dec 20.


Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.

Breiderhoff T, Christiansen GB, Pallesen LT, Vaegter C, Nykjaer A, Holm MM, Glerup S, Willnow TE.

PLoS One. 2013 Sep 19;8(9):e75006. doi: 10.1371/journal.pone.0075006. eCollection 2013.


SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.

Burgert T, Schmidt V, Caglayan S, Lin F, Füchtbauer A, Füchtbauer EM, Nykjaer A, Carlo AS, Willnow TE.

Mol Cell Biol. 2013 Nov;33(21):4308-20. doi: 10.1128/MCB.00628-13. Epub 2013 Sep 3.


SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

Rohe M, Hartl D, Fjorback AN, Klose J, Willnow TE.

PLoS One. 2013 Aug 19;8(8):e72164. doi: 10.1371/journal.pone.0072164. eCollection 2013.


Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease.

Willnow TE, Andersen OM.

J Cell Sci. 2013 Jul 1;126(Pt 13):2751-60. doi: 10.1242/jcs.125393. Epub 2013 Jun 26. Review.


Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.

Hartl D, Klatt S, Roch M, Konthur Z, Klose J, Willnow TE, Rohe M.

PLoS One. 2013 Jun 11;8(6):e65920. doi: 10.1371/journal.pone.0065920. Print 2013.


The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.

Carlo AS, Gustafsen C, Mastrobuoni G, Nielsen MS, Burgert T, Hartl D, Rohe M, Nykjaer A, Herz J, Heeren J, Kempa S, Petersen CM, Willnow TE.

J Neurosci. 2013 Jan 2;33(1):358-70. doi: 10.1523/JNEUROSCI.2425-12.2013.


Endocytic receptor-mediated control of morphogen signaling.

Willnow TE, Christ A, Hammes A.

Development. 2012 Dec 1;139(23):4311-9. doi: 10.1242/dev.084467. Review.


The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.

Herda S, Raczkowski F, Mittrücker HW, Willimsky G, Gerlach K, Kühl AA, Breiderhoff T, Willnow TE, Dörken B, Höpken UE, Rehm A.

Immunity. 2012 Nov 16;37(5):854-66. doi: 10.1016/j.immuni.2012.07.012. Epub 2012 Oct 16.


SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.

Capsoni S, Carlo AS, Vignone D, Amato G, Criscuolo C, Willnow TE, Cattaneo A.

J Alzheimers Dis. 2013;33(2):357-71. doi: 10.3233/JAD-2012-121399.


Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.

Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14241-6. doi: 10.1073/pnas.1203834109. Epub 2012 Aug 13. Erratum in: Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15072.


Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease.

Lao A, Schmidt V, Schmitz Y, Willnow TE, Wolkenhauer O.

BMC Syst Biol. 2012 Jun 22;6:74. doi: 10.1186/1752-0509-6-74.


Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.

Caglayan S, Bauerfeind A, Schmidt V, Carlo AS, Prabakaran T, Hübner N, Willnow TE.

Arch Neurol. 2012 Mar;69(3):373-9. doi: 10.1001/archneurol.2011.788.


Sortilin: a receptor to regulate neuronal viability and function.

Nykjaer A, Willnow TE.

Trends Neurosci. 2012 Apr;35(4):261-70. doi: 10.1016/j.tins.2012.01.003. Epub 2012 Feb 16. Review.


LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.

Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A.

Dev Cell. 2012 Feb 14;22(2):268-78. doi: 10.1016/j.devcel.2011.11.023.

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