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Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway.
Yao H, Zhang X, Zhang N, Li J, Li Y, Wei Q. Yao H, et al. J Nat Med. 2021 Jan;75(1):178-185. doi: 10.1007/s11418-020-01447-0. Epub 2020 Aug 31. J Nat Med. 2021. PMID: 32865667
In our research interest to discover phytochemicals targeting TNBC, we have investigated wikstromol from Wikstroemia indica using the human TNBC MDA-MB-231 cells. The results showed wikstromol at 10 muM inhibited cell growth of MDA-MB-231 cells which was confirmed b …
In our research interest to discover phytochemicals targeting TNBC, we have investigated wikstromol from Wikstroemia indica using the …
Wikstromol, antitumor lignan from Wikstroemia foetida var. oahuensis Gray and Wikstroemia uva-ursi Gray (Thymelaeaceae).
Torrance SJ, Hoffmann JJ, Cole JR. Torrance SJ, et al. J Pharm Sci. 1979 May;68(5):664-5. doi: 10.1002/jps.2600680545. J Pharm Sci. 1979. PMID: 430516
The ethanol extracts of Wikstroemia foetida var. oahuensis and Wikstroemia uva-ursi showed antitumor activity against the P-388 lymphocytic leukemia (3PS) test system One PS-active constituent of both plants was the lignan wikstromol. Several inactive compounds were identi …
The ethanol extracts of Wikstroemia foetida var. oahuensis and Wikstroemia uva-ursi showed antitumor activity against the P-388 lymphocytic …
[A new lignan from Euscaphis konishii].
Chen JX, Ni L, Zhang Y, Fu JR, Huang W, Zou SQ. Chen JX, et al. Zhongguo Zhong Yao Za Zhi. 2021 Apr;46(8):2072-2078. doi: 10.19540/j.cnki.cjcmm.20200629.201. Zhongguo Zhong Yao Za Zhi. 2021. PMID: 33982522 Chinese.
The structures of the chemical components were elucidated by spectroscopy methods, as konilignan(1),(7R, 8S)-dihydrodehydrodico-niferylalcohol-9-O-beta-D-glucopyranoside(2),illiciumlignan B(3),threo-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-1,3-panedi …
The structures of the chemical components were elucidated by spectroscopy methods, as konilignan(1),(7R, 8S)-dihydrodehydrodico-niferylalcoh …
Constituents from the Seeds of Sophora Alopecuroides L.
Rong ZJ, Hu GS, Lin SY, Yan T, Li N, Zhao Y, Jia JM, Wang AH. Rong ZJ, et al. Molecules. 2020 Jan 19;25(2):411. doi: 10.3390/molecules25020411. Molecules. 2020. PMID: 31963799 Free PMC article.
Three new isoflavone glucosides, kudonol A-C (1-3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4-5) and five known compounds, (-)-maackiain (6), neoliquiritin (7), methyl 4-coumarate (8), methyl ferulate (9) and (+)-wikstromol (10), were isolated fro …
Three new isoflavone glucosides, kudonol A-C (1-3), two new ester derivatives of phenylpropanoid, kudolignan A and B (4-5) and five known co …
Enantioselective synthesis of (-)-wikstromol using a new approach via malic acid.
Sefkow M. Sefkow M. J Org Chem. 2001 Apr 6;66(7):2343-9. doi: 10.1021/jo001547z. J Org Chem. 2001. PMID: 11281774
The total synthesis of (-)-wikstromol, a bioactive alpha-hydroxylated lactone lignan, from natural malic acid using a consecutive alkylation strategy is presented. ...This derivative was reacted in a second alkylation step to a double benzylated dioxolanone, which was tran …
The total synthesis of (-)-wikstromol, a bioactive alpha-hydroxylated lactone lignan, from natural malic acid using a consecutive alk …
Chemical constituents and biological activities from roots of Enkleia siamensis.
Rajachan OA, Kanokmedhakul S, Nasomjai P, Kanokmedhakul K. Rajachan OA, et al. Nat Prod Res. 2014;28(4):268-70. doi: 10.1080/14786419.2013.838241. Epub 2013 Sep 18. Nat Prod Res. 2014. PMID: 24047498
Their structures were established on the basis of 1D and 2D NMR spectroscopic data as linobiflavonoid (1), chamaejasmin (2), 7-O-beta-D-glucopyranosylchamaejasmin (3), ormocarpin (4), (-)-wikstromol (5), matairesinol (6), (+)-lariciresinol (7), umbelliferone (8), daphnoret …
Their structures were established on the basis of 1D and 2D NMR spectroscopic data as linobiflavonoid (1), chamaejasmin (2), 7-O-beta-D-gluc …
Simultaneous high-performance liquid chromatographic determination of Cedrus deodara active constituents and their pharmacokinetic profile in mice.
Sachin BS, Koul M, Zutshi A, Singh SK, Tikoo AK, Tikoo MK, Saxena AK, Sharma SC, Johri RK. Sachin BS, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):237-41. doi: 10.1016/j.jchromb.2007.12.015. Epub 2007 Dec 28. J Chromatogr B Analyt Technol Biomed Life Sci. 2008. PMID: 18191624
Good linearity (r2>0.999) was observed over the studied range of 0.015-5.0microg/ml for wikstromol and 0.030-5.0microg/ml for matairesinol and dibenzylbutyrolactol. The CV values of intra-day precision for wikstromol, matairesinol and dibenzylbutyrolactol were in …
Good linearity (r2>0.999) was observed over the studied range of 0.015-5.0microg/ml for wikstromol and 0.030-5.0microg/ml for mata …
[Phenolic constituents from Wikstroemia chamaedaphne].
Liang X, Jiao YY, Wang WH, Li SF, Zhang LW. Liang X, et al. Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):962-967. doi: 10.19540/j.cnki.cjcmm.2019.0017. Zhongguo Zhong Yao Za Zhi. 2019. PMID: 30989856 Chinese.
Thirteen phenolic compounds were isolated and elucidated,including five flavonoids: luteolin 7-O-beta-D-glucopyranoside(1),luteolin 4'-O-beta-D-glucopyranoside(2),kaempferol 3-O-beta-D-glucopyranoside(3),chrysoeriol 4'-O-beta-D-glucopyranoside(4),chrysoeriol(5); and eight lignans …
Thirteen phenolic compounds were isolated and elucidated,including five flavonoids: luteolin 7-O-beta-D-glucopyranoside(1),luteolin 4'-O-bet …
Stereoselectivity questions in the synthesis of wikstromol.
Belletire JL, Ho DM, Fry DF. Belletire JL, et al. J Nat Prod. 1990 Nov-Dec;53(6):1587-92. doi: 10.1021/np50072a034. J Nat Prod. 1990. PMID: 2089125
Besides establishing the course of this oxidation and confirming the proposed structure of wikstromol and related lignans, a single-crystal X-ray study on a wikstromol stereoisomer provides complementary data for comparison with the "natural" isomer....
Besides establishing the course of this oxidation and confirming the proposed structure of wikstromol and related lignans, a single-c …
[A new lignan from rhizome of Stellera chamaejasme].
Liu SN, He J, Wang XX, Ma BZ, Zhang WK, Xu JK. Liu SN, et al. Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(8):1649-1653. doi: 10.19540/j.cnki.cjcmm.20180116.003. Zhongguo Zhong Yao Za Zhi. 2018. PMID: 29751712 Chinese.
To investigate the chemical compounds from the rhizome of Stellera chamaejasme, nine lignans, including stellerachamin A (1), 8-hydroxypluviatolide (2), wikstromol (3), pinoresinol (4), matairesinol (5), dextrobursehernin (6), hinokinin(7), (-)-glaberide I (8) and (-) medi …
To investigate the chemical compounds from the rhizome of Stellera chamaejasme, nine lignans, including stellerachamin A (1), 8-hydroxypluvi …
52 results