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Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE3Leiden mice.

Morrison MC, Liang W, Mulder P, Verschuren L, Pieterman E, Toet K, Heeringa P, Wielinga PY, Kooistra T, Kleemann R.

J Hepatol. 2014 Dec 13. pii: S0168-8278(14)00929-5. doi: 10.1016/j.jhep.2014.12.011. [Epub ahead of print]


A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone.

Verschuren L, Wielinga PY, Kelder T, Radonjic M, Salic K, Kleemann R, van Ommen B, Kooistra T.

BMC Med Genomics. 2014 Jun 17;7:35. doi: 10.1186/1755-8794-7-35.


Coordinated and interactive expression of genes of lipid metabolism and inflammation in adipose tissue and liver during metabolic overload.

Liang W, Tonini G, Mulder P, Kelder T, van Erk M, van den Hoek AM, Mariman R, Wielinga PY, Baccini M, Kooistra T, Biggeri A, Kleemann R.

PLoS One. 2013 Sep 25;8(9):e75290. doi: 10.1371/journal.pone.0075290. eCollection 2013.


Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet.

Yakala GK, Wielinga PY, Suarez M, Bunschoten A, van Golde JM, Arola L, Keijer J, Kleemann R, Kooistra T, Heeringa P.

Mol Nutr Food Res. 2013 Nov;57(11):2039-48. doi: 10.1002/mnfr.201200858. Epub 2013 Aug 15.


Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Radonjic M, Wielinga PY, Wopereis S, Kelder T, Goelela VS, Verschuren L, Toet K, van Duyvenvoorde W, van der Werff van der Vat B, Stroeve JH, Cnubben N, Kooistra T, van Ommen B, Kleemann R.

PLoS One. 2013;8(2):e56122. doi: 10.1371/journal.pone.0056122. Epub 2013 Feb 15.


Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy.

Verschuren L, Radonjic M, Wielinga PY, Kelder T, Kooistra T, van Ommen B, Kleemann R.

Pharmacogenet Genomics. 2012 Dec;22(12):837-45. doi: 10.1097/FPC.0b013e328359d274.


Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function.

Yakala GK, van der Heijden R, Molema G, Schipper M, Wielinga PY, Kleemann R, Kooistra T, Heeringa P.

PLoS One. 2012;7(9):e45866. doi: 10.1371/journal.pone.0045866. Epub 2012 Sep 25.


Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice.

Wielinga PY, Harthoorn LF, Verschuren L, Schoemaker MH, Jouni ZE, van Tol EA, Kleemann R, Kooistra T.

Mol Nutr Food Res. 2012 Jul;56(7):1081-9. doi: 10.1002/mnfr.201100762. Epub 2012 May 18.


Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice.

Gierman LM, van der Ham F, Koudijs A, Wielinga PY, Kleemann R, Kooistra T, Stoop R, Kloppenburg M, van Osch GJ, Stojanovic-Susulic V, Huizinga TW, Zuurmond AM.

Arthritis Rheum. 2012 Apr;64(4):1172-81. doi: 10.1002/art.33443. Epub 2011 Oct 27.


A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.

Kleemann R, Bureeva S, Perlina A, Kaput J, Verschuren L, Wielinga PY, Hurt-Camejo E, Nikolsky Y, van Ommen B, Kooistra T.

BMC Syst Biol. 2011 Aug 12;5:125. doi: 10.1186/1752-0509-5-125.


Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.

Kleemann R, Verschuren L, Morrison M, Zadelaar S, van Erk MJ, Wielinga PY, Kooistra T.

Atherosclerosis. 2011 Sep;218(1):44-52. doi: 10.1016/j.atherosclerosis.2011.04.023. Epub 2011 May 5.


Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation.

Wielinga PY, Yakala GK, Heeringa P, Kleemann R, Kooistra T.

PLoS One. 2011 Mar 31;6(3):e18432. doi: 10.1371/journal.pone.0018432.


A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice.

Verschuren L, Wielinga PY, van Duyvenvoorde W, Tijani S, Toet K, van Ommen B, Kooistra T, Kleemann R.

J Nutr. 2011 May;141(5):863-9. doi: 10.3945/jn.110.133751. Epub 2011 Mar 16.


Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-κB activity and lowering of cholesterol.

de Vries-van der Weij J, Toet K, Zadelaar S, Wielinga PY, Kleemann R, Rensen PC, Kooistra T.

Atherosclerosis. 2010 Nov;213(1):241-6. doi: 10.1016/j.atherosclerosis.2010.09.006. Epub 2010 Sep 21.


Central amylin acts as an adiposity signal to control body weight and energy expenditure.

Wielinga PY, Löwenstein C, Muff S, Munz M, Woods SC, Lutz TA.

Physiol Behav. 2010 Aug 4;101(1):45-52. doi: 10.1016/j.physbeh.2010.04.012. Epub 2010 Apr 21.


Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, Wielinga PY, Schraenen A, Lemaire K, Debray S, Van Lommel L, Pospisilik JA, Tschopp O, Schultze SM, Malipiero U, Esterbauer H, Ellingsgaard H, Rütti S, Schuit FC, Lutz TA, Böni-Schnetzler M, Konrad D, Donath MY.

Diabetologia. 2010 Aug;53(8):1795-806. doi: 10.1007/s00125-010-1747-3. Epub 2010 Apr 21.


Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.

Kleemann R, van Erk M, Verschuren L, van den Hoek AM, Koek M, Wielinga PY, Jie A, Pellis L, Bobeldijk-Pastorova I, Kelder T, Toet K, Wopereis S, Cnubben N, Evelo C, van Ommen B, Kooistra T.

PLoS One. 2010 Jan 21;5(1):e8817. doi: 10.1371/journal.pone.0008817.


The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance.

Boersma GJ, Scheurink AJ, Wielinga PY, Steimer TJ, Benthem L.

Physiol Behav. 2009 Jun 22;97(3-4):353-8. doi: 10.1016/j.physbeh.2009.03.005. Epub 2009 Mar 16.


Vaccination against GIP for the treatment of obesity.

Fulurija A, Lutz TA, Sladko K, Osto M, Wielinga PY, Bachmann MF, Saudan P.

PLoS One. 2008 Sep 9;3(9):e3163. doi: 10.1371/journal.pone.0003163.


In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer.

Bilik KU, Ergüven E, Klussmann S, Jarosch F, Wielinga PY, Lutz TA, Riediger T.

Neuroreport. 2007 Nov 19;18(17):1855-9.

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