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Results: 1 to 20 of 31

1.

An industry perspective on the role and utility of animal models of pain in drug discovery.

Whiteside GT, Pomonis JD, Kennedy JD.

Neurosci Lett. 2013 Dec 17;557 Pt A:65-72. doi: 10.1016/j.neulet.2013.08.033. Epub 2013 Aug 27. Review.

PMID:
23994390
[PubMed - indexed for MEDLINE]
2.

Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).

O'Neill DJ, Adedoyin A, Bray JA, Deecher DC, Fensome A, Goldberg JA, Harrison J, Leventhal L, Mann C, Mark L, Nogle L, Sullivan NR, Spangler TB, Terefenko EA, Trybulski EJ, Uveges AJ, Vu A, Whiteside GT, Zhang P.

J Med Chem. 2011 Oct 13;54(19):6824-31. doi: 10.1021/jm200733r. Epub 2011 Sep 14.

PMID:
21916421
[PubMed - indexed for MEDLINE]
3.

Consideration of Pharmacokinetic Pharmacodynamic Relationships in the Discovery of New Pain Drugs.

Whiteside GT, Kennedy JD.

In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton, FL: CRC Press; 2010. Chapter 16.

PMID:
21882464
[PubMed]
Books & Documents
4.

Dynamic changes in the microRNA expression profile reveal multiple regulatory mechanisms in the spinal nerve ligation model of neuropathic pain.

von Schack D, Agostino MJ, Murray BS, Li Y, Reddy PS, Chen J, Choe SE, Strassle BW, Li C, Bates B, Zhang L, Hu H, Kotnis S, Bingham B, Liu W, Whiteside GT, Samad TA, Kennedy JD, Ajit SK.

PLoS One. 2011 Mar 14;6(3):e17670. doi: 10.1371/journal.pone.0017670.

PMID:
21423802
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.

Chanda PK, Gao Y, Mark L, Btesh J, Strassle BW, Lu P, Piesla MJ, Zhang MY, Bingham B, Uveges A, Kowal D, Garbe D, Kouranova EV, Ring RH, Bates B, Pangalos MN, Kennedy JD, Whiteside GT, Samad TA.

Mol Pharmacol. 2010 Dec;78(6):996-1003. doi: 10.1124/mol.110.068304. Epub 2010 Sep 20.

PMID:
20855465
[PubMed - indexed for MEDLINE]
Free Article
6.

Inflammatory cytokine and chemokine expression is differentially modulated acutely in the dorsal root ganglion in response to different nerve root compressions.

Rothman SM, Ma LH, Whiteside GT, Winkelstein BA.

Spine (Phila Pa 1976). 2011 Feb 1;36(3):197-202. doi: 10.1097/BRS.0b013e3181ce4f4d.

PMID:
20714281
[PubMed - indexed for MEDLINE]
7.

Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.

McIlvain HB, Ma L, Ludwig B, Manners MT, Martone RL, Dunlop J, Kaftan EJ, Kennedy JD, Whiteside GT.

Eur J Pharmacol. 2010 Sep 25;643(2-3):202-10. doi: 10.1016/j.ejphar.2010.06.046. Epub 2010 Jul 13.

PMID:
20621081
[PubMed - indexed for MEDLINE]
8.

Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.

Hummel M, Cummons T, Lu P, Mark L, Harrison JE, Kennedy JD, Whiteside GT.

Neuropharmacology. 2010 Sep;59(3):160-6. doi: 10.1016/j.neuropharm.2010.05.001. Epub 2010 May 12.

PMID:
20470804
[PubMed - indexed for MEDLINE]
9.

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P.

J Med Chem. 2010 Jun 10;53(11):4511-21. doi: 10.1021/jm100053t.

PMID:
20462211
[PubMed - indexed for MEDLINE]
10.

Depression-like phenotype following chronic CB1 receptor antagonism.

Beyer CE, Dwyer JM, Piesla MJ, Platt BJ, Shen R, Rahman Z, Chan K, Manners MT, Samad TA, Kennedy JD, Bingham B, Whiteside GT.

Neurobiol Dis. 2010 Aug;39(2):148-55. doi: 10.1016/j.nbd.2010.03.020. Epub 2010 Apr 8.

PMID:
20381618
[PubMed - indexed for MEDLINE]
11.

Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.

Kotnis S, Bingham B, Vasilyev DV, Miller SW, Bai Y, Yeola S, Chanda PK, Bowlby MR, Kaftan EJ, Samad TA, Whiteside GT.

Mol Pharmacol. 2010 Jun;77(6):953-60. doi: 10.1124/mol.110.063636. Epub 2010 Mar 11.

PMID:
20223879
[PubMed - indexed for MEDLINE]
Free Article
12.

Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.

Fensome A, Goldberg J, McComas CC, Trybulski EJ, Woodworth RP, Deecher DC, Whiteside GT, Zhang P.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1555-8. doi: 10.1016/j.bmcl.2010.01.056. Epub 2010 Jan 20.

PMID:
20153188
[PubMed - indexed for MEDLINE]
13.

Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.

Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, Pangalos MN, Samad TA, Doherty P.

J Neurosci. 2010 Feb 10;30(6):2017-24. doi: 10.1523/JNEUROSCI.5693-09.2010.

PMID:
20147530
[PubMed - indexed for MEDLINE]
Free Article
14.

1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.

Vu AT, Cohn ST, Zhang P, Kim CY, Mahaney PE, Bray JA, Johnston GH, Koury EJ, Cosmi SA, Deecher DC, Smith VA, Harrison JE, Leventhal L, Whiteside GT, Kennedy JD, Trybulski EJ.

J Med Chem. 2010 Mar 11;53(5):2051-62. doi: 10.1021/jm901559e.

PMID:
20131864
[PubMed - indexed for MEDLINE]
15.

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.

Filler AG, Whiteside GT, Bacon M, Frederickson M, Howe FA, Rabinowitz MD, Sokoloff AJ, Deacon TW, Abell C, Munglani R, Griffiths JR, Bell BA, Lever AM.

BMC Neurosci. 2010 Jan 20;11:8. doi: 10.1186/1471-2202-11-8.

PMID:
20085661
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders.

Hughes ZA, Liu F, Marquis K, Muniz L, Pangalos MN, Ring RH, Whiteside GT, Brandon NJ.

Curr Mol Pharmacol. 2009 Nov;2(3):215-36. Review.

PMID:
20021460
[PubMed - indexed for MEDLINE]
17.

1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.

Zhang P, Terefenko EA, Bray J, Deecher D, Fensome A, Harrison J, Kim C, Koury E, Mark L, McComas CC, Mugford CA, Trybulski EJ, Vu AT, Whiteside GT, Mahaney PE.

J Med Chem. 2009 Sep 24;52(18):5703-11. doi: 10.1021/jm900888c.

PMID:
19722525
[PubMed - indexed for MEDLINE]
18.

Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.

Piesla MJ, Leventhal L, Strassle BW, Harrison JE, Cummons TA, Lu P, Whiteside GT.

Brain Res. 2009 Oct 27;1295:89-98. doi: 10.1016/j.brainres.2009.07.091. Epub 2009 Aug 3.

PMID:
19651113
[PubMed - indexed for MEDLINE]
19.

CNS penetration of small molecules following local inflammation, widespread systemic inflammation or direct injury to the nervous system.

Lu P, Gonzales C, Chen Y, Adedoyin A, Hummel M, Kennedy JD, Whiteside GT.

Life Sci. 2009 Sep 9;85(11-12):450-6. doi: 10.1016/j.lfs.2009.07.009. Epub 2009 Jul 24.

PMID:
19632245
[PubMed - indexed for MEDLINE]
20.

Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake, body weight change, and pruritus in rats.

Ward SJ, Lefever TW, Rawls SM, Whiteside GT, Walker EA.

Psychopharmacology (Berl). 2009 Sep;206(1):155-65. doi: 10.1007/s00213-009-1592-6. Epub 2009 Jul 3.

PMID:
19575185
[PubMed - indexed for MEDLINE]

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