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Items: 1 to 20 of 190

1.

Structure of the poly-C9 component of the complement membrane attack complex.

Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RH, Ekkel SM, Kondos SC, Goode RJ, Ramm G, Whisstock JC, Saibil HR, Dunstone MA.

Nat Commun. 2016 Feb 4;7:10588. doi: 10.1038/ncomms10588.

PMID:
26841934
2.

Stonefish toxin defines an ancient branch of the perforin-like superfamily.

Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15360-5. doi: 10.1073/pnas.1507622112. Epub 2015 Dec 1.

PMID:
26627714
3.

Giant MACPF/CDC pore forming toxins: A class of their own.

Reboul CF, Whisstock JC, Dunstone MA.

Biochim Biophys Acta. 2016 Mar;1858(3):475-86. doi: 10.1016/j.bbamem.2015.11.017. Epub 2015 Nov 26.

PMID:
26607011
4.

TcpM, a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens.

Wisniewski JA, Traore DA, Bannam TL, Lyras D, Whisstock JC, Rood JI.

Mol Microbiol. 2015 Nov 12. doi: 10.1111/mmi.13270. [Epub ahead of print]

PMID:
26560080
5.

Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding.

Stewart SE, Bird CH, Tabor RF, D'Angelo ME, Piantavigna S, Whisstock JC, Trapani JA, Martin LL, Bird PI.

J Biol Chem. 2015 Dec 25;290(52):31101-12. doi: 10.1074/jbc.M115.683078. Epub 2015 Nov 5.

PMID:
26542805
6.

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.

Johnson TK, Henstridge MA, Herr A, Moore KA, Whisstock JC, Warr CG.

Nat Commun. 2015 Oct 28;6:8759. doi: 10.1038/ncomms9759.

7.

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.

Yagi H, Conroy PJ, Leung EW, Law RH, Trapani JA, Voskoboinik I, Whisstock JC, Norton RS.

J Biol Chem. 2015 Oct 16;290(42):25213-26. doi: 10.1074/jbc.M115.668384. Epub 2015 Aug 25.

PMID:
26306037
8.

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.

PMID:
26112412
9.

Preferential Acquisition and Activation of Plasminogen Glycoform II by PAM Positive Group A Streptococcal Isolates.

De Oliveira DM, Law RH, Ly D, Cook SM, Quek AJ, McArthur JD, Whisstock JC, Sanderson-Smith ML.

Biochemistry. 2015 Jun 30;54(25):3960-8. doi: 10.1021/acs.biochem.5b00130. Epub 2015 Jun 18.

PMID:
26029848
10.

Perforin and granzymes: function, dysfunction and human pathology.

Voskoboinik I, Whisstock JC, Trapani JA.

Nat Rev Immunol. 2015 Jun;15(6):388-400. Review.

PMID:
25998963
11.

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development.

Giousoh A, Vaz R, Bryson-Richardson RJ, Whisstock JC, Verkade H, Bird PI.

Gene Expr Patterns. 2015 May-Jul;18(1-2):37-43. doi: 10.1016/j.gep.2015.05.002. Epub 2015 May 14.

PMID:
25981450
12.

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase.

Cork AJ, Ericsson DJ, Law RH, Casey LW, Valkov E, Bertozzi C, Stamp A, Jovcevski B, Aquilina JA, Whisstock JC, Walker MJ, Kobe B.

PLoS One. 2015 Mar 25;10(3):e0121764. doi: 10.1371/journal.pone.0121764. eCollection 2015.

13.

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.

Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.

PMID:
25729923
14.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.

15.

GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome.

Li F, Li C, Wang M, Webb GI, Zhang Y, Whisstock JC, Song J.

Bioinformatics. 2015 May 1;31(9):1411-9. doi: 10.1093/bioinformatics/btu852. Epub 2015 Jan 6.

PMID:
25568279
16.

A new model for pore formation by cholesterol-dependent cytolysins.

Reboul CF, Whisstock JC, Dunstone MA.

PLoS Comput Biol. 2014 Aug 21;10(8):e1003791. doi: 10.1371/journal.pcbi.1003791. eCollection 2014 Aug.

17.

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.

Ellisdon AM, Zhang Q, Henstridge MA, Johnson TK, Warr CG, Law RH, Whisstock JC.

BMC Struct Biol. 2014 Apr 24;14:14. doi: 10.1186/1472-6807-14-14.

18.

Reconciling the structural attributes of avian antibodies.

Conroy PJ, Law RH, Gilgunn S, Hearty S, Caradoc-Davies TT, Lloyd G, O'Kennedy RJ, Whisstock JC.

J Biol Chem. 2014 May 30;289(22):15384-92. doi: 10.1074/jbc.M114.562470. Epub 2014 Apr 15.

19.

Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like.

Henstridge MA, Johnson TK, Warr CG, Whisstock JC.

Nat Commun. 2014 Mar 3;5:3419. doi: 10.1038/ncomms4419.

PMID:
24584029
20.

The perforin pore facilitates the delivery of cationic cargos.

Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20.

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