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Results: 1 to 20 of 179


Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase.

Cork AJ, Ericsson DJ, Law RH, Casey LW, Valkov E, Bertozzi C, Stamp A, Jovcevski B, Aquilina JA, Whisstock JC, Walker MJ, Kobe B.

PLoS One. 2015 Mar 25;10(3):e0121764. doi: 10.1371/journal.pone.0121764. eCollection 2015.


IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.

Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF.

Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2.


Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.


GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome.

Li F, Li C, Wang M, Webb GI, Zhang Y, Whisstock JC, Song J.

Bioinformatics. 2015 Jan 6. pii: btu852. [Epub ahead of print]


A new model for pore formation by cholesterol-dependent cytolysins.

Reboul CF, Whisstock JC, Dunstone MA.

PLoS Comput Biol. 2014 Aug 21;10(8):e1003791. doi: 10.1371/journal.pcbi.1003791. eCollection 2014 Aug.


High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.

Ellisdon AM, Zhang Q, Henstridge MA, Johnson TK, Warr CG, Law RH, Whisstock JC.

BMC Struct Biol. 2014 Apr 24;14:14. doi: 10.1186/1472-6807-14-14.


Reconciling the structural attributes of avian antibodies.

Conroy PJ, Law RH, Gilgunn S, Hearty S, Caradoc-Davies TT, Lloyd G, O'Kennedy RJ, Whisstock JC.

J Biol Chem. 2014 May 30;289(22):15384-92. doi: 10.1074/jbc.M114.562470. Epub 2014 Apr 15.


Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like.

Henstridge MA, Johnson TK, Warr CG, Whisstock JC.

Nat Commun. 2014 Mar 3;5:3419. doi: 10.1038/ncomms4419.


The perforin pore facilitates the delivery of cationic cargos.

Stewart SE, Kondos SC, Matthews AY, D'Angelo ME, Dunstone MA, Whisstock JC, Trapani JA, Bird PI.

J Biol Chem. 2014 Mar 28;289(13):9172-81. doi: 10.1074/jbc.M113.544890. Epub 2014 Feb 20.


Maspin is not required for embryonic development or tumour suppression.

Teoh SS, Vieusseux J, Prakash M, Berkowicz S, Luu J, Bird CH, Law RH, Rosado C, Price JT, Whisstock JC, Bird PI.

Nat Commun. 2014;5:3164. doi: 10.1038/ncomms4164.


The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori.

Pang SS, Nguyen ST, Perry AJ, Day CJ, Panjikar S, Tiralongo J, Whisstock JC, Kwok T.

J Biol Chem. 2014 Mar 7;289(10):6332-40. doi: 10.1074/jbc.M113.513135. Epub 2013 Dec 27.


Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1.

Li SH, Reinke AA, Sanders KL, Emal CD, Whisstock JC, Stuckey JA, Lawrence DA.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4941-9. doi: 10.1073/pnas.1216499110. Epub 2013 Dec 2.


New insights into the structure and function of the plasminogen/plasmin system.

Law RH, Abu-Ssaydeh D, Whisstock JC.

Curr Opin Struct Biol. 2013 Dec;23(6):836-41. doi: 10.1016/ Epub 2013 Nov 16. Review.


Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets.

Wang M, Zhao XM, Tan H, Akutsu T, Whisstock JC, Song J.

Bioinformatics. 2014 Jan 1;30(1):71-80. doi: 10.1093/bioinformatics/btt603. Epub 2013 Oct 21.


Assembling the machinery of coagulation.

Whisstock JC.

Blood. 2013 Oct 17;122(16):2773-4. doi: 10.1182/blood-2013-08-516898. No abstract available.


A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications.

Byrne H, Conroy PJ, Whisstock JC, O'Kennedy RJ.

Trends Biotechnol. 2013 Nov;31(11):621-32. doi: 10.1016/j.tibtech.2013.08.007. Epub 2013 Oct 2. Review.


Defining the interaction of perforin with calcium and the phospholipid membrane.

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I.

Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999.


Structural biology: Torqueing about pores.

Whisstock JC, Dunstone MA.

Nat Chem Biol. 2013 Oct;9(10):605-6. doi: 10.1038/nchembio.1341.


Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing.

Johnson TK, Crossman T, Foote KA, Henstridge MA, Saligari MJ, Forbes Beadle L, Herr A, Whisstock JC, Warr CG.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14688-92. doi: 10.1073/pnas.1309780110. Epub 2013 Aug 19.


The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome.

Yongqing T, Wilmann PG, Reeve SB, Coetzer TH, Smith AI, Whisstock JC, Pike RN, Wijeyewickrema LC.

J Biol Chem. 2013 Aug 2;288(31):22399-407. doi: 10.1074/jbc.M113.483875. Epub 2013 Jun 21. Erratum in: J Biol Chem. 2013 Sep 27;288(39):28307.

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