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Results: 1 to 20 of 52

1.

Efficient genome engineering of Toxoplasma gondii using CRISPR/Cas9.

Sidik SM, Hackett CG, Tran F, Westwood NJ, Lourido S.

PLoS One. 2014 Jun 27;9(6):e100450. doi: 10.1371/journal.pone.0100450. eCollection 2014.

PMID:
24971596
[PubMed - in process]
Free PMC Article
2.

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion.

Leung JM, Tran F, Pathak RB, Poupart S, Heaslip AT, Ballif BA, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 3;9(6):e98056. doi: 10.1371/journal.pone.0098056. eCollection 2014.

PMID:
24892871
[PubMed - in process]
Free PMC Article
3.

Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle.

Tilley LD, Krishnamurthy S, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 2;9(6):e98492. doi: 10.1371/journal.pone.0098492. eCollection 2014.

PMID:
24887026
[PubMed - in process]
Free PMC Article
4.

Targeting of the MYCN protein with small molecule c-MYC inhibitors.

Müller I, Larsson K, Frenzel A, Oliynyk G, Zirath H, Prochownik EV, Westwood NJ, Henriksson MA.

PLoS One. 2014 May 23;9(5):e97285. doi: 10.1371/journal.pone.0097285. eCollection 2014.

PMID:
24859015
[PubMed - in process]
Free PMC Article
5.

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia.

Groves MJ, Johnson CE, James J, Prescott AR, Cunningham J, Haydock S, Pepper C, Fegan C, Pirrie L, Westwood NJ, Coates PJ, Ganley IG, Tauro S.

Br J Cancer. 2013 Oct 29;109(9):2434-44. doi: 10.1038/bjc.2013.601. Epub 2013 Oct 3.

PMID:
24091621
[PubMed - indexed for MEDLINE]
6.

A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening.

Tran F, Odell AV, Ward GE, Westwood NJ.

Molecules. 2013 Sep 23;18(9):11639-57. doi: 10.3390/molecules180911639.

PMID:
24064457
[PubMed - in process]
Free PMC Article
7.

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S.

Sci Rep. 2013;3:1275. doi: 10.1038/srep01275.

PMID:
23429453
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner.

McCarthy AR, Sachweh MC, Higgins M, Campbell J, Drummond CJ, van Leeuwen IM, Pirrie L, Ladds MJ, Westwood NJ, Laín S.

Mol Cancer Ther. 2013 Apr;12(4):352-60. doi: 10.1158/1535-7163.MCT-12-0900. Epub 2013 Jan 15.

PMID:
23322738
[PubMed - indexed for MEDLINE]
Free Article
9.

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.

Zhou L, Stewart G, Rideau E, Westwood NJ, Smith TK.

J Med Chem. 2013 Feb 14;56(3):796-806. doi: 10.1021/jm301215e. Epub 2013 Jan 15.

PMID:
23281892
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The synthesis of melohenine B and a related natural product.

Lancefield CS, Zhou L, Lébl T, Slawin AM, Westwood NJ.

Org Lett. 2012 Dec 21;14(24):6166-9. doi: 10.1021/ol302859j. Epub 2012 Dec 5.

PMID:
23214465
[PubMed - indexed for MEDLINE]
11.

Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.

Alphey MS, Pirrie L, Torrie LS, Boulkeroua WA, Gardiner M, Sarkar A, Maringer M, Oehlmann W, Brenk R, Scherman MS, McNeil M, Rejzek M, Field RA, Singh M, Gray D, Westwood NJ, Naismith JH.

ACS Chem Biol. 2013 Feb 15;8(2):387-96. doi: 10.1021/cb300426u. Epub 2012 Nov 28.

PMID:
23138692
[PubMed - in process]
Free Article
12.

Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity.

Pirrie L, McCarthy AR, Major LL, Morkūnaitė V, Zubrienė A, Matulis D, Lain S, Lebl T, Westwood NJ.

Molecules. 2012 Oct 18;17(10):12206-24. doi: 10.3390/molecules171012206.

PMID:
23079492
[PubMed - indexed for MEDLINE]
Free Article
13.

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.

Brear P, Telford J, Taylor GL, Westwood NJ.

Chembiochem. 2012 Nov 5;13(16):2374-83. doi: 10.1002/cbic.201200433. Epub 2012 Oct 15.

PMID:
23070966
[PubMed - indexed for MEDLINE]
14.

ALDH2 mediates 5-nitrofuran activity in multiple species.

Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE.

Chem Biol. 2012 Jul 27;19(7):883-92. doi: 10.1016/j.chembiol.2012.05.017.

PMID:
22840776
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.

McCarthy AR, Pirrie L, Hollick JJ, Ronseaux S, Campbell J, Higgins M, Staples OD, Tran F, Slawin AM, Lain S, Westwood NJ.

Bioorg Med Chem. 2012 Mar 1;20(5):1779-93. doi: 10.1016/j.bmc.2012.01.001. Epub 2012 Jan 12.

PMID:
22304848
[PubMed - indexed for MEDLINE]
16.

Mechanism-specific signatures for small-molecule p53 activators.

van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, Westwood NJ, Laín S.

Cell Cycle. 2011 May 15;10(10):1590-8. Epub 2011 May 15.

PMID:
21490429
[PubMed - indexed for MEDLINE]
Free Article
17.

Asymmetric catalytic oxidative cleavage of polycyclic systems: the synthesis of atropisomeric diazonanes and diazecanes.

Jones AM, Liu G, Lorion MM, Patterson S, Lebl T, Slawin AM, Westwood NJ.

Chemistry. 2011 May 9;17(20):5714-8. doi: 10.1002/chem.201003188. Epub 2011 Apr 5.

PMID:
21469229
[PubMed - indexed for MEDLINE]
18.

Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase.

Walton JG, Jones DC, Kiuru P, Durie AJ, Westwood NJ, Fairlamb AH.

ChemMedChem. 2011 Feb 7;6(2):321-8. doi: 10.1002/cmdc.201000442. Epub 2010 Dec 15.

PMID:
21275055
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin.

Lawson CP, Slawin AM, Westwood NJ.

Chem Commun (Camb). 2011 Jan 21;47(3):1057-9. doi: 10.1039/c0cc03624b. Epub 2010 Nov 15.

PMID:
21079840
[PubMed - indexed for MEDLINE]
20.

The discovery of nongenotoxic activators of p53: building on a cell-based high-throughput screen.

McCarthy AR, Hollick JJ, Westwood NJ.

Semin Cancer Biol. 2010 Feb;20(1):40-5. doi: 10.1016/j.semcancer.2010.02.007. Epub 2010 Mar 4. Review.

PMID:
20206696
[PubMed - indexed for MEDLINE]

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