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Items: 1 to 20 of 65

1.

Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis.

Healy AR, Izumikawa M, Slawin AM, Shin-Ya K, Westwood NJ.

Angew Chem Weinheim Bergstr Ger. 2015 Mar 23;127(13):4118-4122. Epub 2015 Feb 4.

2.

Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

Oueis E, Jaspars M, Westwood NJ, Naismith JH.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5842-5. doi: 10.1002/anie.201601564. Epub 2016 Apr 5.

PMID:
27059105
3.

Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.

Sidik SM, Hortua Triana MA, Paul AS, El Bakkouri M, Hackett CG, Tran F, Westwood NJ, Hui R, Zuercher WJ, Duraisingh MT, Moreno SN, Lourido S.

J Biol Chem. 2016 Apr 29;291(18):9566-80. doi: 10.1074/jbc.M115.703546. Epub 2016 Mar 1.

4.

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach.

Oueis E, Adamson C, Mann G, Ludewig H, Redpath P, Migaud M, Westwood NJ, Naismith JH.

Chembiochem. 2015 Dec;16(18):2646-50. doi: 10.1002/cbic.201500494. Epub 2015 Nov 10.

PMID:
26507241
5.

Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction.

Healy AR, Westwood NJ.

Org Biomol Chem. 2015 Nov 14;13(42):10527-31. doi: 10.1039/c5ob01771h. Epub 2015 Sep 4.

PMID:
26337398
6.

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.

Figuera-Losada M, Stathis M, Dorskind JM, Thomas AG, Bandaru VV, Yoo SW, Westwood NJ, Rogers GW, McArthur JC, Haughey NJ, Slusher BS, Rojas C.

PLoS One. 2015 May 26;10(5):e0124481. doi: 10.1371/journal.pone.0124481. eCollection 2015.

7.

Aromatic monomers by in situ conversion of reactive intermediates in the acid-catalyzed depolymerization of lignin.

Deuss PJ, Scott M, Tran F, Westwood NJ, de Vries JG, Barta K.

J Am Chem Soc. 2015 Jun 17;137(23):7456-67. doi: 10.1021/jacs.5b03693. Epub 2015 Jun 5.

PMID:
26001165
8.

The use of residual dipolar coupling for conformational analysis of structurally related natural products.

Lancefield CS, Slawin AM, Westwood NJ, Lebl T.

Magn Reson Chem. 2015 Jun;53(6):467-75. doi: 10.1002/mrc.4213. Epub 2015 Apr 9.

PMID:
25854705
9.

Yeast three-hybrid screen identifies TgBRADIN/GRA24 as a negative regulator of Toxoplasma gondii bradyzoite differentiation.

Odell AV, Tran F, Foderaro JE, Poupart S, Pathak R, Westwood NJ, Ward GE.

PLoS One. 2015 Mar 19;10(3):e0120331. doi: 10.1371/journal.pone.0120331. eCollection 2015.

10.

Acetylation site specificities of lysine deacetylase inhibitors in human cells.

Schölz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C.

Nat Biotechnol. 2015 Apr;33(4):415-23. doi: 10.1038/nbt.3130. Epub 2015 Mar 9.

PMID:
25751058
11.

Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis.

Healy AR, Izumikawa M, Slawin AM, Shin-Ya K, Westwood NJ.

Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4046-50. doi: 10.1002/anie.201411141. Epub 2015 Feb 4.

12.

Total synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers.

Healy AR, Vinale F, Lorito M, Westwood NJ.

Org Lett. 2015 Feb 6;17(3):692-5. doi: 10.1021/ol503717r. Epub 2015 Jan 28.

13.

Isolation of functionalized phenolic monomers through selective oxidation and C-O bond cleavage of the β-O-4 linkages in lignin.

Lancefield CS, Ojo OS, Tran F, Westwood NJ.

Angew Chem Int Ed Engl. 2015 Jan 2;54(1):258-62. doi: 10.1002/anie.201409408. Epub 2014 Nov 5.

PMID:
25377996
14.

Efficient genome engineering of Toxoplasma gondii using CRISPR/Cas9.

Sidik SM, Hackett CG, Tran F, Westwood NJ, Lourido S.

PLoS One. 2014 Jun 27;9(6):e100450. doi: 10.1371/journal.pone.0100450. eCollection 2014.

15.

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion.

Leung JM, Tran F, Pathak RB, Poupart S, Heaslip AT, Ballif BA, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 3;9(6):e98056. doi: 10.1371/journal.pone.0098056. eCollection 2014.

16.

Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle.

Tilley LD, Krishnamurthy S, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 2;9(6):e98492. doi: 10.1371/journal.pone.0098492. eCollection 2014.

17.

Targeting of the MYCN protein with small molecule c-MYC inhibitors.

Müller I, Larsson K, Frenzel A, Oliynyk G, Zirath H, Prochownik EV, Westwood NJ, Henriksson MA.

PLoS One. 2014 May 23;9(5):e97285. doi: 10.1371/journal.pone.0097285. eCollection 2014.

18.

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia.

Groves MJ, Johnson CE, James J, Prescott AR, Cunningham J, Haydock S, Pepper C, Fegan C, Pirrie L, Westwood NJ, Coates PJ, Ganley IG, Tauro S.

Br J Cancer. 2013 Oct 29;109(9):2434-44. doi: 10.1038/bjc.2013.601. Epub 2013 Oct 3.

19.

A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening.

Tran F, Odell AV, Ward GE, Westwood NJ.

Molecules. 2013 Sep 23;18(9):11639-57. doi: 10.3390/molecules180911639.

20.

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S.

Sci Rep. 2013;3:1275. doi: 10.1038/srep01275.

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