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Results: 19

1.

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2).

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS.

J Med Chem. 2014 Jul 30. [Epub ahead of print]

PMID:
25075558
[PubMed - as supplied by publisher]
2.

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.

Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, Xie T, Marto JA, Chen Z, Gray NS, Westover KD.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8895-900. doi: 10.1073/pnas.1404639111. Epub 2014 Jun 2.

PMID:
24889603
[PubMed - indexed for MEDLINE]
3.

Radiation therapy as a backbone of treatment of locally advanced non-small cell lung cancer.

Laine AM, Westover KD, Choy H.

Semin Oncol. 2014 Feb;41(1):57-68. doi: 10.1053/j.seminoncol.2013.12.012. Epub 2013 Dec 12. Review.

PMID:
24565581
[PubMed - indexed for MEDLINE]
4.

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor.

Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, Carrasco M, Hunter J, Kim ND, Xie T, Sim T, Jänne PA, Meyerson M, Marto JA, Engen JR, Gray NS.

Angew Chem Int Ed Engl. 2014 Jan 3;53(1):199-204. doi: 10.1002/anie.201307387. Epub 2013 Nov 20.

PMID:
24259466
[PubMed - in process]
5.

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS.

Cancer Res. 2013 Apr 15;73(8):2574-86. doi: 10.1158/0008-5472.CAN-12-1702. Epub 2013 Feb 22.

PMID:
23436801
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S.

Cell. 2012 Aug 31;150(5):987-1001. doi: 10.1016/j.cell.2012.06.047.

PMID:
22939624
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Proton SBRT for medically inoperable stage I NSCLC.

Westover KD, Seco J, Adams JA, Lanuti M, Choi NC, Engelsman M, Willers H.

J Thorac Oncol. 2012 Jun;7(6):1021-5. doi: 10.1097/JTO.0b013e31824de0bf.

PMID:
22551902
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Should a sentinel node biopsy be performed in patients with high-risk breast cancer?

Westover KD, Westover MB, Winer EP, Richardson AL, Iglehart JD, Punglia RS.

Int J Breast Cancer. 2011;2011:973245. doi: 10.4061/2011/973245. Epub 2011 Aug 10.

PMID:
22295240
[PubMed]
Free PMC Article
9.

Significance testing as perverse probabilistic reasoning.

Westover MB, Westover KD, Bianchi MT.

BMC Med. 2011 Feb 28;9:20. doi: 10.1186/1741-7015-9-20.

PMID:
21356064
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Comprehensive and efficient HBB mutation analysis for detection of beta-hemoglobinopathies in a pan-ethnic population.

Chan OT, Westover KD, Dietz L, Zehnder JL, Schrijver I.

Am J Clin Pathol. 2010 May;133(5):700-7. doi: 10.1309/AJCP7HQ2KWGHECIO.

PMID:
20395516
[PubMed - indexed for MEDLINE]
Free Article
11.

Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.

Wang D, Bushnell DA, Huang X, Westover KD, Levitt M, Kornberg RD.

Science. 2009 May 29;324(5931):1203-6. doi: 10.1126/science.1168729.

PMID:
19478184
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis.

Wang D, Bushnell DA, Westover KD, Kaplan CD, Kornberg RD.

Cell. 2006 Dec 1;127(5):941-54.

PMID:
17129781
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Structural basis of eukaryotic gene transcription.

Boeger H, Bushnell DA, Davis R, Griesenbeck J, Lorch Y, Strattan JS, Westover KD, Kornberg RD.

FEBS Lett. 2005 Feb 7;579(4):899-903. Review.

PMID:
15680971
[PubMed - indexed for MEDLINE]
Free Article
14.

Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center.

Batada NN, Westover KD, Bushnell DA, Levitt M, Kornberg RD.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17361-4. Epub 2004 Dec 1.

PMID:
15574497
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.

Westover KD, Bushnell DA, Kornberg RD.

Cell. 2004 Nov 12;119(4):481-9. Erratum in: Cell.2004 Dec 29;119(7):1055.

PMID:
15537538
[PubMed - indexed for MEDLINE]
Free Article
16.

Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs.

Wilson JE, Chandrasekharan NV, Westover KD, Eager KB, Simmons DL.

Am J Vet Res. 2004 Jun;65(6):810-8.

PMID:
15198222
[PubMed - indexed for MEDLINE]
17.

Structural basis of transcription: separation of RNA from DNA by RNA polymerase II.

Westover KD, Bushnell DA, Kornberg RD.

Science. 2004 Feb 13;303(5660):1014-6.

PMID:
14963331
[PubMed - indexed for MEDLINE]
Free Article
18.

Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms.

Bushnell DA, Westover KD, Davis RE, Kornberg RD.

Science. 2004 Feb 13;303(5660):983-8.

PMID:
14963322
[PubMed - indexed for MEDLINE]
Free Article
19.

Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex.

Anant JS, Desnoyers L, Machius M, Demeler B, Hansen JC, Westover KD, Deisenhofer J, Seabra MC.

Biochemistry. 1998 Sep 8;37(36):12559-68.

PMID:
9730828
[PubMed - indexed for MEDLINE]

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