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Results: 1 to 20 of 25

1.

Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

Pizarro JC, Hills T, Senisterra G, Wernimont AK, Mackenzie C, Norcross NR, Ferguson MA, Wyatt PG, Gilbert IH, Hui R.

PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2492. doi: 10.1371/journal.pntd.0002492. eCollection 2013.

2.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.

Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M.

Nat Commun. 2012;3:1288. doi: 10.1038/ncomms2304. Erratum in: Nat Commun. 2013;4:1893.

PMID:
23250418
3.

Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.

El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA.

J Biol Chem. 2013 Jan 11;288(2):1022-31. doi: 10.1074/jbc.M112.416560. Epub 2012 Nov 28.

4.

Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase.

Bandini G, Mariño K, Güther ML, Wernimont AK, Kuettel S, Qiu W, Afzal S, Kelner A, Hui R, Ferguson MA.

Mol Microbiol. 2012 Aug;85(3):513-34. doi: 10.1111/j.1365-2958.2012.08124.x. Epub 2012 Jul 12.

5.

Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding.

Qiu W, Dong A, Pizarro JC, Botchkarsev A, Min J, Wernimont AK, Hills T, Hui R, Artz JD.

BMC Struct Biol. 2012 Mar 19;12:2. doi: 10.1186/1472-6807-12-2.

6.

Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E.

Siddiqui N, Tempel W, Nedyalkova L, Volpon L, Wernimont AK, Osborne MJ, Park HW, Borden KL.

J Mol Biol. 2012 Feb 3;415(5):781-92. doi: 10.1016/j.jmb.2011.12.002. Epub 2011 Dec 9.

7.

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction.

Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T.

Proteins. 2011;79 Suppl 10:6-20. doi: 10.1002/prot.23196. Epub 2011 Oct 21.

8.

The Cryptosporidium parvum kinome.

Artz JD, Wernimont AK, Allali-Hassani A, Zhao Y, Amani M, Lin YH, Senisterra G, Wasney GA, Fedorov O, King O, Roos A, Lunin VV, Qiu W, Finerty P Jr, Hutchinson A, Chau I, von Delft F, MacKenzie F, Lew J, Kozieradzki I, Vedadi M, Schapira M, Zhang C, Shokat K, Heightman T, Hui R.

BMC Genomics. 2011 Sep 30;12:478. doi: 10.1186/1471-2164-12-478.

9.

Characterization of 14-3-3 proteins from Cryptosporidium parvum.

Brokx SJ, Wernimont AK, Dong A, Wasney GA, Lin YH, Lew J, Vedadi M, Lee WH, Hui R.

PLoS One. 2011;6(8):e14827. doi: 10.1371/journal.pone.0014827. Epub 2011 Aug 11.

10.

Characterization of a new phosphatase from Plasmodium.

Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC.

Mol Biochem Parasitol. 2011 Oct;179(2):69-79. doi: 10.1016/j.molbiopara.2011.06.001. Epub 2011 Jun 13.

PMID:
21689687
11.

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.

Mariño K, Güther ML, Wernimont AK, Qiu W, Hui R, Ferguson MA.

Eukaryot Cell. 2011 Jul;10(7):985-97. doi: 10.1128/EC.05025-11. Epub 2011 Apr 29.

12.

Structures of parasitic CDPK domains point to a common mechanism of activation.

Wernimont AK, Amani M, Qiu W, Pizarro JC, Artz JD, Lin YH, Lew J, Hutchinson A, Hui R.

Proteins. 2011 Mar;79(3):803-20. doi: 10.1002/prot.22919. Epub 2010 Dec 3.

PMID:
21287613
13.

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.

Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R.

J Biol Chem. 2011 Feb 4;286(5):3315-22. doi: 10.1074/jbc.M109.027235. Epub 2010 Nov 17.

14.

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.

Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, Ferguson MA.

Glycobiology. 2010 Dec;20(12):1619-30. doi: 10.1093/glycob/cwq115. Epub 2010 Aug 19.

15.

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.

Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R.

Nat Struct Mol Biol. 2010 May;17(5):596-601. doi: 10.1038/nsmb.1795. Epub 2010 May 2.

16.

Isolation and crystallization of a unique size category of recombinant Rabies virus Nucleoprotein-RNA rings.

Albertini AA, Clapier CR, Wernimont AK, Schoehn G, Weissenhorn W, Ruigrok RW.

J Struct Biol. 2007 Apr;158(1):129-33. Epub 2006 Oct 24.

PMID:
17126031
17.

Crystal structure of the rabies virus nucleoprotein-RNA complex.

Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, Schoehn G, Weissenhorn W, Ruigrok RW.

Science. 2006 Jul 21;313(5785):360-3. Epub 2006 Jun 15.

18.

Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II.

Wernimont AK, Weissenhorn W.

BMC Struct Biol. 2004 Dec 4;4(1):10.

19.

Binding of copper(I) by the Wilson disease protein and its copper chaperone.

Wernimont AK, Yatsunyk LA, Rosenzweig AC.

J Biol Chem. 2004 Mar 26;279(13):12269-76. Epub 2004 Jan 6.

20.

Crystal structure and dimerization equilibria of PcoC, a methionine-rich copper resistance protein from Escherichia coli.

Wernimont AK, Huffman DL, Finney LA, Demeler B, O'Halloran TV, Rosenzweig AC.

J Biol Inorg Chem. 2003 Jan;8(1-2):185-94. Epub 2002 Sep 27.

PMID:
12459914
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