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Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells.

Jensen K, Gallagher IJ, Kaliszewska A, Zhang C, Abejide O, Gallagher MP, Werling D, Glass EJ.

Vet Res. 2016 Mar 22;47:46. doi: 10.1186/s13567-016-0328-y.


Differential macrophage function in Brown Swiss and Holstein Friesian cattle.

Gibson AJ, Woodman S, Pennelegion C, Patterson R, Stuart E, Hosker N, Siviter P, Douglas C, Whitehouse J, Wilkinson W, Pegg SA, Villarreal-Ramos B, Werling D.

Vet Immunol Immunopathol. 2016 Feb 28. pii: S0165-2427(16)30026-5. doi: 10.1016/j.vetimm.2016.02.018. [Epub ahead of print]


Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders.

Werling DM, Parikshak NN, Geschwind DH.

Nat Commun. 2016 Feb 19;7:10717. doi: 10.1038/ncomms10717.


Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals.

Woodman S, Gibson AJ, García AR, Contreras GS, Rossen JW, Werling D, Offord V.

Vet Immunol Immunopathol. 2016 Jan;169:10-4. doi: 10.1016/j.vetimm.2015.11.006. Epub 2015 Dec 1.


Gene coexpression modules in human cognition.

Werling DM, Sanders SJ.

Nat Neurosci. 2016 Jan 27;19(2):173-5. doi: 10.1038/nn.4226. No abstract available.


The PsychENCODE project.

PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N.

Nat Neurosci. 2015 Dec;18(12):1707-12. doi: 10.1038/nn.4156. Review. No abstract available.


Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo.

Patterson R, Eley T, Browne C, Martineau HM, Werling D.

Vaccine. 2015 Nov 17;33(46):6199-205. doi: 10.1016/j.vaccine.2015.10.003. Epub 2015 Oct 21.


Vaccination of calves with yeast- and bacterial-expressed paramyosin from the bovine lungworm Dictyocaulus viviparus.

Joekel D, Hinse P, Raulf MK, Schicht S, Bäumer W, Werling D, Kremmer E, Strube C.

Parasite Immunol. 2015 Dec;37(12):614-23. doi: 10.1111/pim.12280.


Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.

Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF 3rd, Klei L, Mandell JD, Moreno-De-Luca D, Poultney CS, Robinson EB, Smith L, Solli-Nowlan T, Su MY, Teran NA, Walker MF, Werling DM, Beaudet AL, Cantor RM, Fombonne E, Geschwind DH, Grice DE, Lord C, Lowe JK, Mane SM, Martin DM, Morrow EM, Talkowski ME, Sutcliffe JS, Walsh CA, Yu TW; Autism Sequencing Consortium, Ledbetter DH, Martin CL, Cook EH, Buxbaum JD, Daly MJ, Devlin B, Roeder K, State MW.

Neuron. 2015 Sep 23;87(6):1215-33. doi: 10.1016/j.neuron.2015.09.016.


Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils.

Conejeros I, Gibson AJ, Werling D, Muñoz-Caro T, Hermosilla C, Taubert A, Burgos RA.

Dev Comp Immunol. 2015 Oct;52(2):215-25. doi: 10.1016/j.dci.2015.05.012. Epub 2015 May 27.


Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins.

Werling DM, Geschwind DH.

Mol Autism. 2015 May 13;6:27. doi: 10.1186/s13229-015-0004-5. eCollection 2015.


Bovine macrophages sense Escherichia coli Shiga toxin 1.

Menge C, Loos D, Bridger PS, Barth S, Werling D, Baljer G.

Innate Immun. 2015 Aug;21(6):655-64. doi: 10.1177/1753425915581215. Epub 2015 Apr 23.


Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.

Patterson R, Nevel A, Diaz AV, Martineau HM, Demmers T, Browne C, Mavrommatis B, Werling D.

Vet Microbiol. 2015 Jun 12;177(3-4):261-9. doi: 10.1016/j.vetmic.2015.03.010. Epub 2015 Mar 20.


Effects of ex-vivo and in-vivo treatment with probiotics on the inflammasome in dogs with chronic enteropathy.

Schmitz S, Werling D, Allenspach K.

PLoS One. 2015 Mar 23;10(3):e0120779. doi: 10.1371/journal.pone.0120779. eCollection 2015.


A prospective, randomized, blinded, placebo-controlled pilot study on the effect of Enterococcus faecium on clinical activity and intestinal gene expression in canine food-responsive chronic enteropathy.

Schmitz S, Glanemann B, Garden OA, Brooks H, Chang YM, Werling D, Allenspach K.

J Vet Intern Med. 2015 Mar-Apr;29(2):533-43. doi: 10.1111/jvim.12563. Epub 2015 Mar 16.


Lack of correlation between mucosal immunoglobulin A-positive plasma cell numbers and TLR5 genotypes in German shepherd dogs with idiopathic chronic enteropathy.

Lee A, Kathrani A, Priestnall SL, Smith K, Werling D, Allenspach K.

J Comp Pathol. 2015 Feb-Apr;152(2-3):201-5. doi: 10.1016/j.jcpa.2015.01.002. Epub 2015 Feb 27.


Social responsiveness, an autism endophenotype: genomewide significant linkage to two regions on chromosome 8.

Lowe JK, Werling DM, Constantino JN, Cantor RM, Geschwind DH.

Am J Psychiatry. 2015 Mar 1;172(3):266-75. doi: 10.1176/appi.ajp.2014.14050576. Epub 2014 Nov 7.


Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response.

Patterson NJ, Günther J, Gibson AJ, Offord V, Coffey TJ, Splitter G, Monk I, Seyfert HM, Werling D.

Front Microbiol. 2014 Dec 9;5:662. doi: 10.3389/fmicb.2014.00662. eCollection 2014.


The phylogeography of rabies in Grenada, West Indies, and implications for control.

Zieger U, Marston DA, Sharma R, Chikweto A, Tiwari K, Sayyid M, Louison B, Goharriz H, Voller K, Breed AC, Werling D, Fooks AR, Horton DL.

PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3251. doi: 10.1371/journal.pntd.0003251. eCollection 2014 Oct.


Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR.

Oguro-Ando A, Rosensweig C, Herman E, Nishimura Y, Werling D, Bill BR, Berg JM, Gao F, Coppola G, Abrahams BS, Geschwind DH.

Mol Psychiatry. 2015 Sep;20(9):1069-78. doi: 10.1038/mp.2014.124. Epub 2014 Oct 14.

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