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Results: 1 to 20 of 48

1.

Enhanced Cardiac Akt/Protein Kinase B Signaling Contributes to Pathological Cardiac Hypertrophy in Part by Impairing Mitochondrial Function via Transcriptional Repression of Mitochondrion-Targeted Nuclear Genes.

Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED.

Mol Cell Biol. 2015 Mar 1;35(5):831-46. doi: 10.1128/MCB.01109-14. Epub 2014 Dec 22.

PMID:
25535334
[PubMed - in process]
2.

Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.

Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, Chatham JC, Wende AR, Yang Q, Chow CW, Martino TA, Gamble KL.

J Biol Rhythms. 2014 Aug;29(4):257-76. doi: 10.1177/0748730414543141.

PMID:
25238855
[PubMed - in process]
Free PMC Article
3.

Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, White MF, Abel ED.

Mol Cell Biol. 2014 Sep 15;34(18):3450-60. doi: 10.1128/MCB.00426-14. Epub 2014 Jul 7.

PMID:
25002528
[PubMed - indexed for MEDLINE]
4.

Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.

Addison O, Drummond MJ, LaStayo PC, Dibble LE, Wende AR, McClain DA, Marcus RL.

J Nutr Health Aging. 2014 May;18(5):532-8. doi: 10.1007/s12603-014-0019-1.

PMID:
24886741
[PubMed - in process]
5.

Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.

Pereira RO, Wende AR, Crum A, Hunter D, Olsen CD, Rawlings T, Riehle C, Ward WF, Abel ED.

FASEB J. 2014 Aug;28(8):3691-702. doi: 10.1096/fj.14-253823. Epub 2014 Apr 28.

PMID:
24776744
[PubMed - indexed for MEDLINE]
6.

GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.

Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Riehle C, Abel ED.

J Mol Cell Cardiol. 2014 Jul;72:95-103. doi: 10.1016/j.yjmcc.2014.02.011. Epub 2014 Feb 25.

PMID:
24583251
[PubMed - indexed for MEDLINE]
7.

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.

Lopez-Izquierdo A, Pereira RO, Wende AR, Punske BB, Abel ED, Tristani-Firouzi M.

Am J Physiol Heart Circ Physiol. 2014 Mar 1;306(5):H747-54. doi: 10.1152/ajpheart.00849.2013. Epub 2013 Dec 27.

PMID:
24375641
[PubMed - indexed for MEDLINE]
8.

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.

Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel ED.

J Clin Invest. 2013 Dec;123(12):5319-33. doi: 10.1172/JCI71171. Epub 2013 Nov 1.

PMID:
24177427
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction.

Pereira RO, Wende AR, Olsen C, Soto J, Rawlings T, Zhu Y, Anderson SM, Abel ED.

J Am Heart Assoc. 2013 Sep 19;2(5):e000301. doi: 10.1161/JAHA.113.000301.

PMID:
24052497
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

APpEaLINg therapeutic target for obesity cardiomyopathy?

Wende AR, Young ME.

J Mol Cell Cardiol. 2013 Oct;63:165-8. doi: 10.1016/j.yjmcc.2013.08.001. Epub 2013 Aug 12. No abstract available.

PMID:
23948484
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α.

Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED.

Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H41-51. doi: 10.1152/ajpheart.00877.2012. Epub 2013 Apr 26.

PMID:
23624629
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate.

Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV.

PLoS One. 2013;8(3):e57821. doi: 10.1371/journal.pone.0057821. Epub 2013 Mar 8.

PMID:
23520482
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.

Zhu Y, Pereira RO, O'Neill BT, Riehle C, Ilkun O, Wende AR, Rawlings TA, Zhang YC, Zhang Q, Klip A, Shiojima I, Walsh K, Abel ED.

Mol Endocrinol. 2013 Jan;27(1):172-84. doi: 10.1210/me.2012-1210. Epub 2012 Nov 30.

PMID:
23204326
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia.

Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB.

Exp Physiol. 2013 Mar;98(3):746-57. doi: 10.1113/expphysiol.2012.070235. Epub 2012 Nov 23.

PMID:
23180812
[PubMed - indexed for MEDLINE]
15.

Mechanisms of lipotoxicity in the cardiovascular system.

Wende AR, Symons JD, Abel ED.

Curr Hypertens Rep. 2012 Dec;14(6):517-31. doi: 10.1007/s11906-012-0307-2. Review.

PMID:
23054891
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes.

Marcus RL, Addison O, LaStayo PC, Hungerford R, Wende AR, Hoffman JM, Abel ED, McClain DA.

J Endocrinol Invest. 2013 Feb;36(2):111-7. doi: 10.3275/8333. Epub 2012 Apr 5.

PMID:
22522495
[PubMed - indexed for MEDLINE]
17.

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.

Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED.

J Mol Cell Cardiol. 2012 May;52(5):1019-26. doi: 10.1016/j.yjmcc.2012.02.001. Epub 2012 Feb 9.

PMID:
22342406
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.

Li Y, Wende AR, Nunthakungwan O, Huang Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T.

FEBS J. 2012 Feb;279(4):599-611. doi: 10.1111/j.1742-4658.2011.08450.x. Epub 2012 Jan 9.

PMID:
22221582
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Archaeal transcriptional regulation of the prokaryotic KdpFABC complex mediating K(+) uptake in H. salinarum.

Kixmüller D, Strahl H, Wende A, Greie JC.

Extremophiles. 2011 Nov;15(6):643-52. doi: 10.1007/s00792-011-0395-y. Epub 2011 Sep 21.

PMID:
21947979
[PubMed - indexed for MEDLINE]
20.

The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts.

Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel ED, Punske BB.

IEEE Trans Biomed Eng. 2011 Nov;58(11):3175-83. doi: 10.1109/TBME.2011.2164075. Epub 2011 Aug 18.

PMID:
21859611
[PubMed - indexed for MEDLINE]
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