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Effects of varying serum glucose levels on 18F-FDG biodistribution.

Webb RL, Landau E, Klein D, DiPoce J, Volkin D, Belman J, Voutsinas N, Brenner A.

Nucl Med Commun. 2015 Jul;36(7):717-21. doi: 10.1097/MNM.0000000000000319.


trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.

Sellner H, Cottens S, Cumin F, Ehrhardt C, Kosaka T, Lorthiois E, Ostermann N, Webb RL, Rigel DF, Wagner T, Maibaum J.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1787-91. doi: 10.1016/j.bmcl.2015.02.040. Epub 2015 Feb 23.


Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's disease.

Sethi M, Joshi SS, Webb RL, Beckett TL, Donohue KD, Murphy MP, O'Hara BF, Duncan MJ.

Neuroscience. 2015 Apr 2;290:80-9. doi: 10.1016/j.neuroscience.2015.01.035. Epub 2015 Jan 28.


Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.

Ehara T, Irie O, Kosaka T, Kanazawa T, Breitenstein W, Grosche P, Ostermann N, Suzuki M, Kawakami S, Konishi K, Hitomi Y, Toyao A, Gunji H, Cumin F, Schiering N, Wagner T, Rigel DF, Webb RL, Maibaum J, Yokokawa F.

ACS Med Chem Lett. 2014 Apr 21;5(7):787-92. doi: 10.1021/ml500137b. eCollection 2014 Jul 10.


Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology.

Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP.

J Alzheimers Dis. 2014;42(4):1221-7. doi: 10.3233/JAD-132450.


PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats.

Snelder N, Ploeger BA, Luttringer O, Rigel DF, Webb RL, Feldman D, Fu F, Beil M, Jin L, Stanski DR, Danhof M.

Br J Pharmacol. 2013 Aug;169(7):1510-24. doi: 10.1111/bph.12190.


The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.

Lorthiois E, Breitenstein W, Cumin F, Ehrhardt C, Francotte E, Jacoby E, Ostermann N, Sellner H, Kosaka T, Webb RL, Rigel DF, Hassiepen U, Richert P, Wagner T, Maibaum J.

J Med Chem. 2013 Mar 28;56(6):2207-17. doi: 10.1021/jm3017078. Epub 2013 Mar 15.


A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.

Ostermann N, Ruedisser S, Ehrhardt C, Breitenstein W, Marzinzik A, Jacoby E, Vangrevelinghe E, Ottl J, Klumpp M, Hartwieg JC, Cumin F, Hassiepen U, Trappe J, Sedrani R, Geisse S, Gerhartz B, Richert P, Francotte E, Wagner T, Krömer M, Kosaka T, Webb RL, Rigel DF, Maibaum J, Baeschlin DK.

J Med Chem. 2013 Mar 28;56(6):2196-206. doi: 10.1021/jm301706j. Epub 2013 Mar 15.


Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.

Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H 3rd, Keller JN, Murphy MP.

J Alzheimers Dis. 2012;32(1):127-38.


β-Secretases, Alzheimer's Disease, and Down Syndrome.

Webb RL, Murphy MP.

Curr Gerontol Geriatr Res. 2012;2012:362839. doi: 10.1155/2012/362839. Epub 2012 Feb 28.


BACE2 expression increases in human neurodegenerative disease.

Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP.

Am J Pathol. 2012 Jan;180(1):337-50. doi: 10.1016/j.ajpath.2011.09.034. Epub 2011 Nov 7.


Sig2BioPAX: Java tool for converting flat files to BioPAX Level 3 format.

Webb RL, Ma'ayan A.

Source Code Biol Med. 2011 Mar 21;6:5. doi: 10.1186/1751-0473-6-5.


Direct renin inhibitors as a new therapy for hypertension.

Webb RL, Schiering N, Sedrani R, Maibaum J.

J Med Chem. 2010 Nov 11;53(21):7490-520. doi: 10.1021/jm901885s. Review. No abstract available.


Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle.

Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, LeVine H 3rd, Murphy MP.

Neurobiol Dis. 2010 Sep;39(3):449-56. doi: 10.1016/j.nbd.2010.05.018. Epub 2010 May 20.


Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors.

Webb RL, Findlay KA, Green MA, Beckett TL, Murphy MP.

PLoS One. 2010 Mar 19;5(3):e9799. doi: 10.1371/journal.pone.0009799.


BACE1 and BACE2 enzymatic activities in Alzheimer's disease.

Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP.

J Neurochem. 2010 Feb;112(4):1045-53. doi: 10.1111/j.1471-4159.2009.06528.x. Epub 2009 Dec 4.


Using total internal reflection fluorescence (TIRF) microscopy to visualize cortical actin and microtubules in the Drosophila syncytial embryo.

Webb RL, Rozov O, Watkins SC, McCartney BM.

Dev Dyn. 2009 Oct;238(10):2622-32. doi: 10.1002/dvdy.22076.


A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila.

Webb RL, Zhou MN, McCartney BM.

Development. 2009 Apr;136(8):1283-93. doi: 10.1242/dev.026963. Epub 2009 Mar 11.


SNAVI: Desktop application for analysis and visualization of large-scale signaling networks.

Ma'ayan A, Jenkins SL, Webb RL, Berger SI, Purushothaman SP, Abul-Husn NS, Posner JM, Flores T, Iyengar R.

BMC Syst Biol. 2009 Jan 20;3:10. doi: 10.1186/1752-0509-3-10.


Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.

Mulder P, Mellin V, Favre J, Vercauteren M, Remy-Jouet I, Monteil C, Richard V, Renet S, Henry JP, Jeng AY, Webb RL, Thuillez C.

Eur Heart J. 2008 Sep;29(17):2171-9. doi: 10.1093/eurheartj/ehn277. Epub 2008 Jun 27.

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