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Results: 1 to 20 of 41

1.

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis.

Lu H, Talbot S, Robertson KA, Watterson S, Forster T, Roy D, Ghazal P.

Steroids. 2015 Mar 7. pii: S0039-128X(15)00088-4. doi: 10.1016/j.steroids.2015.02.022. [Epub ahead of print]

2.

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway.

Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P.

Biochem Pharmacol. 2013 Jul 1;86(1):56-66. doi: 10.1016/j.bcp.2013.03.021. Epub 2013 Apr 10.

3.

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.

Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P.

Immunity. 2013 Jan 24;38(1):106-18. doi: 10.1016/j.immuni.2012.11.004. Epub 2012 Dec 27.

4.

A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction.

Watterson S, Guerriero ML, Blanc M, Mazein A, Loewe L, Robertson KA, Gibbs H, Shui G, Wenk MR, Hillston J, Ghazal P.

Biochimie. 2013 Mar;95(3):613-21. doi: 10.1016/j.biochi.2012.05.024. Epub 2012 Jun 1.

5.

Digital clocks: simple Boolean models can quantitatively describe circadian systems.

Akman OE, Watterson S, Parton A, Binns N, Millar AJ, Ghazal P.

J R Soc Interface. 2012 Sep 7;9(74):2365-82. doi: 10.1098/rsif.2012.0080. Epub 2012 Apr 12. Erratum in: J R Soc Interface. 2012 Dec 7;9(77):3578.

6.

Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).

Watterson SH, Langevine CM, Van Kirk K, Kempson J, Guo J, Spergel SH, Das J, Moquin RV, Dyckman AJ, Nirschl D, Gregor K, Pattoli MA, Yang X, McIntyre KW, Yang G, Galella MA, Booth-Lute H, Chen L, Yang Z, Wang-Iverson D, McKinnon M, Dodd JH, Barrish JC, Burke JR, Pitts WJ.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7006-12. doi: 10.1016/j.bmcl.2011.09.111. Epub 2011 Oct 5.

PMID:
22018461
7.

Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA.

Valente M, Watterson SJ, Parker MD, Ford RC, Young MT.

Biochim Biophys Acta. 2011 Dec;1808(12):2859-66. doi: 10.1016/j.bbamem.2011.08.025. Epub 2011 Aug 26.

8.

Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.

Blanc M, Hsieh WY, Robertson KA, Watterson S, Shui G, Lacaze P, Khondoker M, Dickinson P, Sing G, Rodríguez-Martín S, Phelan P, Forster T, Strobl B, Müller M, Riemersma R, Osborne T, Wenk MR, Angulo A, Ghazal P.

PLoS Biol. 2011 Mar;9(3):e1000598. doi: 10.1371/journal.pbio.1000598. Epub 2011 Mar 8.

9.

The in silico macrophage: toward a better understanding of inflammatory disease.

Ghazal P, Watterson S, Robertson K, Kluth DC.

Genome Med. 2011 Jan 22;3(1):4. doi: 10.1186/gm218.

10.

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.

Dyckman AJ, Langevine CM, Quesnelle C, Kempson J, Guo J, Gill P, Spergel SH, Watterson SH, Li T, Nirschl DS, Gillooly KM, Pattoli MA, McIntyre KW, Chen L, McKinnon M, Dodd JH, Barrish JC, Burke JR, Pitts WJ.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. doi: 10.1016/j.bmcl.2010.10.133. Epub 2010 Oct 31.

PMID:
21087862
11.

Construction of a large scale integrated map of macrophage pathogen recognition and effector systems.

Raza S, McDerment N, Lacaze PA, Robertson K, Watterson S, Chen Y, Chisholm M, Eleftheriadis G, Monk S, O'Sullivan M, Turnbull A, Roy D, Theocharidis A, Ghazal P, Freeman TC.

BMC Syst Biol. 2010 May 14;4:63. doi: 10.1186/1752-0509-4-63.

12.

Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).

Watterson SH, Xiao Z, Dodd DS, Tortolani DR, Vaccaro W, Potin D, Launay M, Stetsko DK, Skala S, Davis PM, Lee D, Yang X, McIntyre KW, Balimane P, Patel K, Yang Z, Marathe P, Kadiyala P, Tebben AJ, Sheriff S, Chang CY, Ziemba T, Zhang H, Chen BC, DelMonte AJ, Aranibar N, McKinnon M, Barrish JC, Suchard SJ, Murali Dhar TG.

J Med Chem. 2010 May 13;53(9):3814-30. doi: 10.1021/jm100348u.

PMID:
20405922
13.

Use of logic theory in understanding regulatory pathway signaling in response to infection.

Watterson S, Ghazal P.

Future Microbiol. 2010 Feb;5(2):163-76. doi: 10.2217/fmb.10.8. Review.

14.

The Systems Biology Graphical Notation.

Le Novère N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, Demir E, Wegner K, Aladjem MI, Wimalaratne SM, Bergman FT, Gauges R, Ghazal P, Kawaji H, Li L, Matsuoka Y, Villéger A, Boyd SE, Calzone L, Courtot M, Dogrusoz U, Freeman TC, Funahashi A, Ghosh S, Jouraku A, Kim S, Kolpakov F, Luna A, Sahle S, Schmidt E, Watterson S, Wu G, Goryanin I, Kell DB, Sander C, Sauro H, Snoep JL, Kohn K, Kitano H.

Nat Biotechnol. 2009 Aug;27(8):735-41. doi: 10.1038/nbt.1558. Epub 2009 Aug 7. Erratum in: Nat Biotechnol. 2009 Sep;27(9):864.

PMID:
19668183
15.

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

Gillooly KM, Pattoli MA, Taylor TL, Chen L, Cheng L, Gregor KR, Whitney GS, Susulic V, Watterson SH, Kempson J, Pitts WJ, Booth-Lute H, Yang G, Davies P, Kukral DW, Strnad J, McIntyre KW, Darienzo CJ, Salter-Cid L, Yang Z, Wang-Iverson DB, Burke JR.

J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.

16.

Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.

Kempson J, Guo J, Das J, Moquin RV, Spergel SH, Watterson SH, Langevine CM, Dyckman AJ, Pattoli M, Burke JR, Yang X, Gillooly KM, McIntyre KW, Chen L, Dodd JH, McKinnon M, Barrish JC, Pitts WJ.

Bioorg Med Chem Lett. 2009 May 15;19(10):2646-9. doi: 10.1016/j.bmcl.2009.03.159. Epub 2009 Apr 5.

PMID:
19376699
17.

Novel tricyclic inhibitors of IkappaB kinase.

Kempson J, Spergel SH, Guo J, Quesnelle C, Gill P, Belanger D, Dyckman AJ, Li T, Watterson SH, Langevine CM, Das J, Moquin RV, Furch JA, Marinier A, Dodier M, Martel A, Nirschl D, Van Kirk K, Burke JR, Pattoli MA, Gillooly K, McIntyre KW, Chen L, Yang Z, Marathe PH, Wang-Iverson D, Dodd JH, McKinnon M, Barrish JC, Pitts WJ.

J Med Chem. 2009 Apr 9;52(7):1994-2005. doi: 10.1021/jm8015816.

PMID:
19267461
18.

Inferring Boolean networks with perturbation from sparse gene expression data: a general model applied to the interferon regulatory network.

Yu L, Watterson S, Marshall S, Ghazal P.

Mol Biosyst. 2008 Oct;4(10):1024-30. doi: 10.1039/b804649b. Epub 2008 Aug 26.

PMID:
19082142
19.

Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli.

Watterson SJ, Mitra S, Swierczek SI, Bennett B, Holz RC.

Biochemistry. 2008 Nov 11;47(45):11885-93. doi: 10.1021/bi801499g. Epub 2008 Oct 15.

20.

Logic models of pathway biology.

Watterson S, Marshall S, Ghazal P.

Drug Discov Today. 2008 May;13(9-10):447-56. doi: 10.1016/j.drudis.2008.03.019. Epub 2008 Apr 23. Review.

PMID:
18468563
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