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Items: 1 to 20 of 48

1.

Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease.

Porath B, Gainullin VG, Cornec-Le Gall E, Dillinger EK, Heyer CM, Hopp K, Edwards ME, Madsen CD, Mauritz SR, Banks CJ, Baheti S, Reddy B, Herrero JI, Bañales JM, Hogan MC, Tasic V, Watnick TJ, Chapman AB, Vigneau C, Lavainne F, Audrézet MP, Ferec C, Le Meur Y, Torres VE; Genkyst Study Group, HALT Progression of Polycystic Kidney Disease Group; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease, Harris PC.

Am J Hum Genet. 2016 Jun 2;98(6):1193-207. doi: 10.1016/j.ajhg.2016.05.004.

PMID:
27259053
2.

The polycystin complex mediates Wnt/Ca(2+) signalling.

Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L.

Nat Cell Biol. 2016 Jul;18(7):752-64. doi: 10.1038/ncb3363. Epub 2016 May 23.

PMID:
27214281
3.

Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice.

Wu X, Indzhykulian AA, Niksch PD, Webber RM, Garcia-Gonzalez M, Watnick T, Zhou J, Vollrath MA, Corey DP.

PLoS One. 2016 May 19;11(5):e0155577. doi: 10.1371/journal.pone.0155577. eCollection 2016.

4.

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease.

Cebotaru L, Liu Q, Yanda MK, Boinot C, Outeda P, Huso DL, Watnick T, Guggino WB, Cebotaru V.

Kidney Int. 2016 Jul;90(1):90-9. doi: 10.1016/j.kint.2016.01.026. Epub 2016 Mar 25.

PMID:
27165822
5.

Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition.

Hofherr A, Wagner CJ, Watnick T, Köttgen M.

Kidney Int. 2016 Apr;89(4):949-55. doi: 10.1016/j.kint.2015.11.015. Epub 2016 Jan 6.

6.

Vascular complications in autosomal dominant polycystic kidney disease.

Perrone RD, Malek AM, Watnick T.

Nat Rev Nephrol. 2015 Oct;11(10):589-98. doi: 10.1038/nrneph.2015.128. Epub 2015 Aug 11. Review.

7.

Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Chapman AB, Devuyst O, Eckardt KU, Gansevoort RT, Harris T, Horie S, Kasiske BL, Odland D, Pei Y, Perrone RD, Pirson Y, Schrier RW, Torra R, Torres VE, Watnick T, Wheeler DC; Conference Participants.

Kidney Int. 2015 Jul;88(1):17-27. doi: 10.1038/ki.2015.59. Epub 2015 Mar 18.

8.

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.

Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, Cebotaru V, Chiaravalli M, Boletta A, Piontek K, Germino GG, Weinman EJ, Watnick T, Qian F.

Nat Commun. 2014 Nov 18;5:5482. doi: 10.1038/ncomms6482.

9.

Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.

Tan M, Wettersten HI, Chu K, Huso DL, Watnick T, Friedlander S, Landesman Y, Weiss RH.

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1179-86. doi: 10.1152/ajprenal.00406.2014. Epub 2014 Sep 18.

10.

Polycystin signaling is required for directed endothelial cell migration and lymphatic development.

Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, Germino GG, Watnick T.

Cell Rep. 2014 May 8;7(3):634-44. doi: 10.1016/j.celrep.2014.03.064. Epub 2014 Apr 24.

11.

Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1-deficient mice.

Fonseca JM, Bastos AP, Amaral AG, Sousa MF, Souza LE, Malheiros DM, Piontek K, Irigoyen MC, Watnick TJ, Onuchic LF.

Kidney Int. 2014 May;85(5):1137-50. doi: 10.1038/ki.2013.501. Epub 2014 Jan 15.

12.

A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease.

Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, Qian F, Huso D, Dietz HC, Germino GG, Watnick T.

J Am Soc Nephrol. 2014 Jan;25(1):81-91. doi: 10.1681/ASN.2012050486. Epub 2013 Sep 26.

13.

Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated.

Watnick TJ, Germino GG.

Nat Rev Nephrol. 2013 May;9(5):249-50. doi: 10.1038/nrneph.2013.73. Epub 2013 Apr 9. No abstract available.

PMID:
23567275
14.

Tolvaptan in patients with autosomal dominant polycystic kidney disease.

Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, Perrone RD, Krasa HB, Ouyang J, Czerwiec FS; TEMPO 3:4 Trial Investigators.

N Engl J Med. 2012 Dec 20;367(25):2407-18. doi: 10.1056/NEJMoa1205511. Epub 2012 Nov 3.

15.

A missense mutation in PKD1 attenuates the severity of renal disease.

Pei Y, Lan Z, Wang K, Garcia-Gonzalez M, He N, Dicks E, Parfrey P, Germino G, Watnick T.

Kidney Int. 2012 Feb;81(4):412-7. doi: 10.1038/ki.2011.370. Epub 2011 Oct 26.

16.

Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience.

Higashihara E, Torres VE, Chapman AB, Grantham JJ, Bae K, Watnick TJ, Horie S, Nutahara K, Ouyang J, Krasa HB, Czerwiec FS; TEMPOFormula and 156-05-002 Study Investigators.

Clin J Am Soc Nephrol. 2011 Oct;6(10):2499-507. doi: 10.2215/CJN.03530411. Epub 2011 Sep 8.

17.

Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels.

Köttgen M, Hofherr A, Li W, Chu K, Cook S, Montell C, Watnick T.

PLoS One. 2011;6(5):e20031. doi: 10.1371/journal.pone.0020031. Epub 2011 May 20.

18.

Polycystin-1 regulates STAT activity by a dual mechanism.

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90. doi: 10.1073/pnas.1103816108. Epub 2011 Apr 25.

19.

Pkd1 and Pkd2 are required for normal placental development.

Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T.

PLoS One. 2010 Sep 16;5(9). pii: e12821. doi: 10.1371/journal.pone.0012821.

20.

Not all renal cysts are created equal.

Shah S, Watnick T, Atta MG.

Lancet. 2010 Sep 18;376(9745):1024. doi: 10.1016/S0140-6736(10)60956-7. No abstract available.

PMID:
20851261
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