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Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively-charged extracellular pore residues.

Farag NE, Jeong D, Claydon T, Warwicker J, Boyett MR.

Am J Physiol Cell Physiol. 2016 Jun 8:ajpcell.00277.2015. doi: 10.1152/ajpcell.00277.2015. [Epub ahead of print]


Energetic Calculations to Decipher pH-Dependent Oligomerization and Domain Swapping of Proteins.

Shingate P, Warwicker J, Sowdhamini R.

PLoS One. 2015 Jun 4;10(6):e0127716. doi: 10.1371/journal.pone.0127716. eCollection 2015.


Computational Tools for Interpreting Ion Channel pH-Dependence.

Sazanavets I, Warwicker J.

PLoS One. 2015 Apr 27;10(4):e0125293. doi: 10.1371/journal.pone.0125293. eCollection 2015.


Breaking and restoring the hydrophobic core of a centromere-binding protein.

Saeed S, Jowitt TA, Warwicker J, Hayes F.

J Biol Chem. 2015 Apr 3;290(14):9273-83. doi: 10.1074/jbc.M115.638148. Epub 2015 Feb 23.


Deciphering complex patterns of class-I HLA-peptide cross-reactivity via hierarchical grouping.

Mukherjee S, Warwicker J, Chandra N.

Immunol Cell Biol. 2015 Jul;93(6):522-32. doi: 10.1038/icb.2015.3. Epub 2015 Feb 24.


Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.

Campion KL, McCormick WD, Warwicker J, Khayat ME, Atkinson-Dell R, Steward MC, Delbridge LW, Mun HC, Conigrave AD, Ward DT.

J Am Soc Nephrol. 2015 Sep;26(9):2163-71. doi: 10.1681/ASN.2014070653. Epub 2015 Jan 2.


Specific ion and buffer effects on protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R.

Mol Pharm. 2015 Jan 5;12(1):179-93. doi: 10.1021/mp500533c. Epub 2014 Dec 2.


Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus.

Karuppiah V, Thistlethwaite A, Dajani R, Warwicker J, Derrick JP.

J Biol Chem. 2014 Nov 28;289(48):33187-97. doi: 10.1074/jbc.M114.608448. Epub 2014 Oct 13.


The role of electrostatics in protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R.

Mol Pharm. 2014 Jul 7;11(7):2475-89. doi: 10.1021/mp5002334. Epub 2014 Jun 18.


The Use of Antibodies in Small-Molecule Drug Discovery.

Marsden CJ, Eckersley S, Hebditch M, Kvist AJ, Milner R, Mitchell D, Warwicker J, Marley AE.

J Biomol Screen. 2014 Jul;19(6):829-38. doi: 10.1177/1087057114527770. Epub 2014 Apr 2. Review.


Lysine and arginine content of proteins: computational analysis suggests a new tool for solubility design.

Warwicker J, Charonis S, Curtis RA.

Mol Pharm. 2014 Jan 6;11(1):294-303. doi: 10.1021/mp4004749. Epub 2013 Nov 27.


Soluble expression of proteins correlates with a lack of positively-charged surface.

Chan P, Curtis RA, Warwicker J.

Sci Rep. 2013 Nov 26;3:3333. doi: 10.1038/srep03333.


Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.

Watson HR, Wunderley L, Andreou T, Warwicker J, High S.

Biochem J. 2013 Dec 1;456(2):297-309. doi: 10.1042/BJ20130100.


Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.

Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D.

Nat Commun. 2013;4:2164. doi: 10.1038/ncomms3164.


The association of BAG6 with SGTA and tail-anchored proteins.

Leznicki P, Roebuck QP, Wunderley L, Clancy A, Krysztofinska EM, Isaacson RL, Warwicker J, Schwappach B, High S.

PLoS One. 2013;8(3):e59590. doi: 10.1371/journal.pone.0059590. Epub 2013 Mar 22.


The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms.

Kemp LR, Dunstan MS, Fisher K, Warwicker J, Leys D.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 11;368(1616):20120323. doi: 10.1098/rstb.2012.0323. Print 2013 Apr 19.


Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours.

Milner R, Wombwell H, Eckersley S, Barnes D, Warwicker J, Van Dorp E, Rowlinson R, Dearden S, Hughes G, Harbron C, Wellings B, Hodgson D, Womack C, Gray N, Lau A, O'Connor MJ, Marsden C, Kvist AJ.

Virchows Arch. 2013 Mar;462(3):269-79. doi: 10.1007/s00428-012-1368-y. Epub 2013 Jan 25. Erratum in: Virchows Arch. 2013 May;462(5):601. Rowlinson, Rachel [added].


Positional editing of transmembrane domains during ion channel assembly.

Öjemalm K, Watson HR, Roboti P, Cross BC, Warwicker J, von Heijne G, High S.

J Cell Sci. 2013 Jan 15;126(Pt 2):464-72. doi: 10.1242/jcs.111773. Epub 2012 Dec 10.


Temperature-dependent study reveals that dynamics of hydrophobic residues plays an important functional role in the mitochondrial Tim9-Tim10 complex.

Ivanova E, Pang J, Jowitt TA, Yan G, Warwicker J, Sutcliffe MJ, Lu H.

Proteins. 2012 Feb;80(2):602-15. doi: 10.1002/prot.23224. Epub 2011 Nov 17.

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