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Results: 1 to 20 of 74

1.

The role of electrostatics in protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R.

Mol Pharm. 2014 Jul 7;11(7):2475-89. doi: 10.1021/mp5002334. Epub 2014 Jun 18.

PMID:
24892385
[PubMed - in process]
2.

The Use of Antibodies in Small-Molecule Drug Discovery.

Marsden CJ, Eckersley S, Hebditch M, Kvist AJ, Milner R, Mitchell D, Warwicker J, Marley AE.

J Biomol Screen. 2014 Apr 2;19(6):829-838. [Epub ahead of print] Review.

PMID:
24695620
[PubMed - as supplied by publisher]
3.

Lysine and arginine content of proteins: computational analysis suggests a new tool for solubility design.

Warwicker J, Charonis S, Curtis RA.

Mol Pharm. 2014 Jan 6;11(1):294-303. doi: 10.1021/mp4004749. Epub 2013 Nov 27.

PMID:
24283752
[PubMed - in process]
Free PMC Article
4.

Soluble expression of proteins correlates with a lack of positively-charged surface.

Chan P, Curtis RA, Warwicker J.

Sci Rep. 2013 Nov 26;3:3333. doi: 10.1038/srep03333.

PMID:
24276756
[PubMed - in process]
5.

Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.

Watson HR, Wunderley L, Andreou T, Warwicker J, High S.

Biochem J. 2013 Dec 1;456(2):297-309. doi: 10.1042/BJ20130100.

PMID:
24015703
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.

Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D.

Nat Commun. 2013;4:2164. doi: 10.1038/ncomms3164.

PMID:
23917065
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The association of BAG6 with SGTA and tail-anchored proteins.

Leznicki P, Roebuck QP, Wunderley L, Clancy A, Krysztofinska EM, Isaacson RL, Warwicker J, Schwappach B, High S.

PLoS One. 2013;8(3):e59590. doi: 10.1371/journal.pone.0059590. Epub 2013 Mar 22.

PMID:
23533635
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The transcriptional regulator CprK detects chlorination by combining direct and indirect readout mechanisms.

Kemp LR, Dunstan MS, Fisher K, Warwicker J, Leys D.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 11;368(1616):20120323. doi: 10.1098/rstb.2012.0323. Print 2013 Apr 19.

PMID:
23479753
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours.

Milner R, Wombwell H, Eckersley S, Barnes D, Warwicker J, Van Dorp E, Rowlinson R, Dearden S, Hughes G, Harbron C, Wellings B, Hodgson D, Womack C, Gray N, Lau A, O'Connor MJ, Marsden C, Kvist AJ.

Virchows Arch. 2013 Mar;462(3):269-79. doi: 10.1007/s00428-012-1368-y. Epub 2013 Jan 25. Erratum in: Virchows Arch. 2013 May;462(5):601. Rowlinson, Rachel [added].

PMID:
23354597
[PubMed - indexed for MEDLINE]
10.

Positional editing of transmembrane domains during ion channel assembly.

Öjemalm K, Watson HR, Roboti P, Cross BC, Warwicker J, von Heijne G, High S.

J Cell Sci. 2013 Jan 15;126(Pt 2):464-72. doi: 10.1242/jcs.111773. Epub 2012 Dec 10.

PMID:
23230148
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

eIF4E-binding protein regulation of mRNAs with differential 5'-UTR secondary structure: a polyelectrostatic model for a component of protein-mRNA interactions.

Cawley A, Warwicker J.

Nucleic Acids Res. 2012 Sep;40(16):7666-75. doi: 10.1093/nar/gks511. Epub 2012 Jun 20.

PMID:
22718971
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Temperature-dependent study reveals that dynamics of hydrophobic residues plays an important functional role in the mitochondrial Tim9-Tim10 complex.

Ivanova E, Pang J, Jowitt TA, Yan G, Warwicker J, Sutcliffe MJ, Lu H.

Proteins. 2011 Oct 19. doi: 10.1002/prot.23224. [Epub ahead of print]

PMID:
22095685
[PubMed - as supplied by publisher]
13.

Progress in the prediction of pKa values in proteins.

Alexov E, Mehler EL, Baker N, Baptista AM, Huang Y, Milletti F, Nielsen JE, Farrell D, Carstensen T, Olsson MH, Shen JK, Warwicker J, Williams S, Word JM.

Proteins. 2011 Dec;79(12):3260-75. doi: 10.1002/prot.23189. Epub 2011 Oct 15. Review.

PMID:
22002859
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

pKa predictions with a coupled finite difference Poisson-Boltzmann and Debye-Hückel method.

Warwicker J.

Proteins. 2011 Dec;79(12):3374-80. doi: 10.1002/prot.23078. Epub 2011 Jun 9.

PMID:
21661058
[PubMed - indexed for MEDLINE]
15.

A biochemical analysis of the constraints of tail-anchored protein biogenesis.

Leznicki P, Warwicker J, High S.

Biochem J. 2011 Jun 15;436(3):719-27. doi: 10.1042/BJ20101737.

PMID:
21466504
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.

Tait S, Dutta K, Cowburn D, Warwicker J, Doig AJ, McCarthy JE.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17627-32. doi: 10.1073/pnas.1008242107. Epub 2010 Sep 28.

PMID:
20880835
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

SitesIdentify: a protein functional site prediction tool.

Bray T, Chan P, Bougouffa S, Greaves R, Doig AJ, Warwicker J.

BMC Bioinformatics. 2009 Nov 18;10:379. doi: 10.1186/1471-2105-10-379.

PMID:
19922660
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Evidence for the adaptation of protein pH-dependence to subcellular pH.

Chan P, Warwicker J.

BMC Biol. 2009 Oct 22;7:69. doi: 10.1186/1741-7007-7-69.

PMID:
19849832
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Stability and solubility of proteins from extremophiles.

Greaves RB, Warwicker J.

Biochem Biophys Res Commun. 2009 Mar 13;380(3):581-5. doi: 10.1016/j.bbrc.2009.01.145. Epub 2009 Jan 29.

PMID:
19285004
[PubMed - indexed for MEDLINE]
20.

Sequence and structural features of enzymes and their active sites by EC class.

Bray T, Doig AJ, Warwicker J.

J Mol Biol. 2009 Mar 13;386(5):1423-36. doi: 10.1016/j.jmb.2008.11.057. Epub 2008 Dec 10.

PMID:
19100748
[PubMed - indexed for MEDLINE]

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