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Results: 1 to 20 of 27

1.

A Conserved Isoleucine Maintains the Inactive State of Bruton's Tyrosine Kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH.

J Mol Biol. 2014 Sep 2. pii: S0022-2836(14)00461-6. doi: 10.1016/j.jmb.2014.08.018. [Epub ahead of print]

PMID:
25193673
[PubMed - as supplied by publisher]
2.

Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain Displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014.

PMID:
25144189
[PubMed - in process]
Free PMC Article
3.

Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties.

Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA.

Anal Chem. 2013 Dec 3;85(23):11185-8. doi: 10.1021/ac403173p. Epub 2013 Nov 14.

PMID:
24215480
[PubMed - indexed for MEDLINE]
4.

Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.

PMID:
23982207
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.

Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A.

Biochemistry. 2013 Jul 23;52(29):5016-26. doi: 10.1021/bi400430k. Epub 2013 Jul 8.

PMID:
23795559
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC.

J Mol Biol. 2013 Sep 9;425(17):3192-204. doi: 10.1016/j.jmb.2013.05.025. Epub 2013 Jun 6.

PMID:
23747483
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).

Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O.

J Biol Chem. 2013 Jul 5;288(27):19845-60. doi: 10.1074/jbc.M113.460170. Epub 2013 May 17.

PMID:
23720744
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE.

Int Rev Phys Chem. 2013 Jan 1;32(1):96-127.

PMID:
23682200
[PubMed]
Free PMC Article
9.

Considerations in the analysis of hydrogen exchange mass spectrometry data.

Wales TE, Eggertson MJ, Engen JR.

Methods Mol Biol. 2013;1007:263-88. doi: 10.1007/978-1-62703-392-3_11.

PMID:
23666730
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.

Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A.

Protein Sci. 2013 Jun;22(6):774-87. doi: 10.1002/pro.2257. Epub 2013 Apr 29.

PMID:
23553709
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE.

J Biol Chem. 2013 Mar 1;288(9):6116-29. doi: 10.1074/jbc.M112.431312. Epub 2013 Jan 9.

PMID:
23303187
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).

Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A.

ACS Chem Neurosci. 2012 May 16;3(5):393-9. doi: 10.1021/cn3000263. Epub 2012 Mar 20.

PMID:
22860208
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE.

BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1.

PMID:
22420777
[PubMed]
Free PMC Article
14.

Conformational locking upon cooperative assembly of notch transcription complexes.

Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC.

Structure. 2012 Feb 8;20(2):340-9. doi: 10.1016/j.str.2011.12.011.

PMID:
22325781
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.

Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC.

Structure. 2011 Apr 13;19(4):546-54. doi: 10.1016/j.str.2011.01.016.

PMID:
21481777
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ.

J Mol Biol. 2010 Apr 23;398(1):40-53. doi: 10.1016/j.jmb.2010.02.040. Epub 2010 Mar 4.

PMID:
20206636
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

High-speed and high-resolution UPLC separation at zero degrees Celsius.

Wales TE, Fadgen KE, Gerhardt GC, Engen JR.

Anal Chem. 2008 Sep 1;80(17):6815-20. doi: 10.1021/ac8008862. Epub 2008 Aug 2.

PMID:
18672890
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Structure and dynamic regulation of Src-family kinases.

Engen JR, Wales TE, Hochrein JM, Meyn MA 3rd, Banu Ozkan S, Bahar I, Smithgall TE.

Cell Mol Life Sci. 2008 Oct;65(19):3058-73. doi: 10.1007/s00018-008-8122-2. Review.

PMID:
18563293
[PubMed - indexed for MEDLINE]
19.

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor.

Trible RP, Emert-Sedlak L, Wales TE, Ayyavoo V, Engen JR, Smithgall TE.

J Mol Biol. 2007 Nov 16;374(1):121-9. Epub 2007 Sep 11.

PMID:
17920628
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis.

Weis DD, Wales TE, Engen JR, Hotchko M, Ten Eyck LF.

J Am Soc Mass Spectrom. 2006 Nov;17(11):1498-509. Epub 2006 Jul 27.

PMID:
16875839
[PubMed - indexed for MEDLINE]
Free Article

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