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Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.

Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR.

Anal Chem. 2015 Jul 21;87(14):7030-5. doi: 10.1021/acs.analchem.5b01725. Epub 2015 Jul 2.


Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Engen JR, Wales TE.

Annu Rev Anal Chem (Palo Alto Calif). 2015 Jul 22;8(1):127-48. doi: 10.1146/annurev-anchem-062011-143113. Epub 2015 May 29.


Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.

Mol Cell. 2015 Mar 5;57(5):873-86. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12.


A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH.

J Mol Biol. 2014 Oct 23;426(21):3656-69. doi: 10.1016/j.jmb.2014.08.018. Epub 2014 Sep 2.


Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014.


Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties.

Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA.

Anal Chem. 2013 Dec 3;85(23):11185-8. doi: 10.1021/ac403173p. Epub 2013 Nov 14.


Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.


Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.

Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A.

Biochemistry. 2013 Jul 23;52(29):5016-26. doi: 10.1021/bi400430k. Epub 2013 Jul 8.


Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC.

J Mol Biol. 2013 Sep 9;425(17):3192-204. doi: 10.1016/j.jmb.2013.05.025. Epub 2013 Jun 6.


Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).

Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O.

J Biol Chem. 2013 Jul 5;288(27):19845-60. doi: 10.1074/jbc.M113.460170. Epub 2013 May 17.


Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE.

Int Rev Phys Chem. 2013 Jan 1;32(1):96-127.


Considerations in the analysis of hydrogen exchange mass spectrometry data.

Wales TE, Eggertson MJ, Engen JR.

Methods Mol Biol. 2013;1007:263-88. doi: 10.1007/978-1-62703-392-3_11.


Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.

Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A.

Protein Sci. 2013 Jun;22(6):774-87. doi: 10.1002/pro.2257. Epub 2013 Apr 29.


Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE.

J Biol Chem. 2013 Mar 1;288(9):6116-29. doi: 10.1074/jbc.M112.431312. Epub 2013 Jan 9.


Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).

Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A.

ACS Chem Neurosci. 2012 May 16;3(5):393-9. doi: 10.1021/cn3000263. Epub 2012 Mar 20.


HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE.

BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1.


Conformational locking upon cooperative assembly of notch transcription complexes.

Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC.

Structure. 2012 Feb 8;20(2):340-9. doi: 10.1016/j.str.2011.12.011.


Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.

Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC.

Structure. 2011 Apr 13;19(4):546-54. doi: 10.1016/j.str.2011.01.016.


Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

Fang J, Rand KD, Silva MC, Wales TE, Engen JR, Beuning PJ.

J Mol Biol. 2010 Apr 23;398(1):40-53. doi: 10.1016/j.jmb.2010.02.040. Epub 2010 Mar 4.


High-speed and high-resolution UPLC separation at zero degrees Celsius.

Wales TE, Fadgen KE, Gerhardt GC, Engen JR.

Anal Chem. 2008 Sep 1;80(17):6815-20. doi: 10.1021/ac8008862. Epub 2008 Aug 2.

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