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Items: 1 to 20 of 37


Allosteric inhibition of antiapoptotic MCL-1.

Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD.

Nat Struct Mol Biol. 2016 Jun;23(6):600-7. doi: 10.1038/nsmb.3223. Epub 2016 May 9.


Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.

Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR.

J Am Soc Mass Spectrom. 2016 Jun;27(6):1048-61. doi: 10.1007/s13361-016-1365-5. Epub 2016 Mar 31.


Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH.

PLoS Comput Biol. 2016 Mar 24;12(3):e1004826. doi: 10.1371/journal.pcbi.1004826. eCollection 2016 Mar.


Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis.

Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK.

J Am Soc Mass Spectrom. 2016 Apr;27(4):662-8. doi: 10.1007/s13361-015-1330-8. Epub 2016 Jan 26.


Dynamics of the Tec-family tyrosine kinase SH3 domains.

Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE.

Protein Sci. 2016 Apr;25(4):852-64. doi: 10.1002/pro.2887. Epub 2016 Mar 18.


Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O.

J Mol Biol. 2016 Jan 29;428(2 Pt B):449-62. doi: 10.1016/j.jmb.2015.10.029. Epub 2015 Nov 10.


Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.

Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR.

Biochemistry. 2015 Oct 20;54(41):6382-91. doi: 10.1021/acs.biochem.5b00875. Epub 2015 Oct 6.


Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.

Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR.

Anal Chem. 2015 Jul 21;87(14):7030-5. doi: 10.1021/acs.analchem.5b01725. Epub 2015 Jul 2.


Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Engen JR, Wales TE.

Annu Rev Anal Chem (Palo Alto Calif). 2015;8:127-48. doi: 10.1146/annurev-anchem-062011-143113. Epub 2015 May 29.


Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.

Mol Cell. 2015 Mar 5;57(5):873-86. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12.


A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase.

Boyken SE, Chopra N, Xie Q, Joseph RE, Wales TE, Fulton DB, Engen JR, Jernigan RL, Andreotti AH.

J Mol Biol. 2014 Oct 23;426(21):3656-69. doi: 10.1016/j.jmb.2014.08.018. Epub 2014 Sep 2.


Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014.


Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties.

Shi XE, Wales TE, Elkin C, Kawahata N, Engen JR, Annis DA.

Anal Chem. 2013 Dec 3;85(23):11185-8. doi: 10.1021/ac403173p. Epub 2013 Nov 14.


Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.


Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.

Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A.

Biochemistry. 2013 Jul 23;52(29):5016-26. doi: 10.1021/bi400430k. Epub 2013 Jul 8.


Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC.

J Mol Biol. 2013 Sep 9;425(17):3192-204. doi: 10.1016/j.jmb.2013.05.025. Epub 2013 Jun 6.


Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).

Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O.

J Biol Chem. 2013 Jul 5;288(27):19845-60. doi: 10.1074/jbc.M113.460170. Epub 2013 May 17.


Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.

Engen JR, Wales TE, Chen S, Marzluff EM, Hassell KM, Weis DD, Smithgall TE.

Int Rev Phys Chem. 2013 Jan 1;32(1):96-127.


Considerations in the analysis of hydrogen exchange mass spectrometry data.

Wales TE, Eggertson MJ, Engen JR.

Methods Mol Biol. 2013;1007:263-88. doi: 10.1007/978-1-62703-392-3_11.


Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.

Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A.

Protein Sci. 2013 Jun;22(6):774-87. doi: 10.1002/pro.2257. Epub 2013 Apr 29.

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