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Results: 1 to 20 of 216

1.

The BET bromodomain inhibitor I-BET151 acts downstream of Smoothened to abrogate the growth of Hedgehog driven cancers.

Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ.

J Biol Chem. 2014 Oct 29. pii: jbc.M114.595348. [Epub ahead of print]

PMID:
25355313
[PubMed - as supplied by publisher]
2.

Emerging treatment strategies for glioblastoma multiforme.

Carlsson SK, Brothers SP, Wahlestedt C.

EMBO Mol Med. 2014 Oct 13. pii: e201302627. doi: 10.15252/emmm.201302627. [Epub ahead of print] Review.

PMID:
25312641
[PubMed - as supplied by publisher]
Free Article
3.

Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.

Plotkin A, Volmar CH, Wahlestedt C, Ayad N, El-Ashry D.

Breast Cancer Res Treat. 2014 Sep;147(2):249-63. doi: 10.1007/s10549-014-3093-5. Epub 2014 Aug 17.

PMID:
25129342
[PubMed - in process]
4.

I-BET151 selectively regulates IL-6 production.

Barrett E, Brothers S, Wahlestedt C, Beurel E.

Biochim Biophys Acta. 2014 Sep;1842(9):1549-55. doi: 10.1016/j.bbadis.2014.05.013. Epub 2014 May 22.

PMID:
24859008
[PubMed - indexed for MEDLINE]
5.

HuD regulates coding and noncoding RNA to induce APP→Aβ processing.

Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, Resnick SM, de Cabo R, Mattson MP, Gorospe M.

Cell Rep. 2014 Jun 12;7(5):1401-9. doi: 10.1016/j.celrep.2014.04.050. Epub 2014 May 22.

PMID:
24857657
[PubMed - in process]
Free Article
6.

Natural antisense transcripts.

Khorkova O, Myers AJ, Hsiao J, Wahlestedt C.

Hum Mol Genet. 2014 Sep 15;23(R1):R54-63. doi: 10.1093/hmg/ddu207. Epub 2014 May 16.

PMID:
24838284
[PubMed - in process]
7.

Non-coding RNAs as direct and indirect modulators of epigenetic regulation.

Peschansky VJ, Wahlestedt C.

Epigenetics. 2014 Jan 1;9(1):3-12. doi: 10.4161/epi.27473.

PMID:
24739571
[PubMed - in process]
Free PMC Article
8.

BET bromodomain proteins are required for glioblastoma cell proliferation.

Pastori C, Daniel M, Penas C, Volmar CH, Johnstone AL, Brothers SP, Graham RM, Allen B, Sarkaria JN, Komotar RJ, Wahlestedt C, Ayad NG.

Epigenetics. 2014 Apr;9(4):611-20. doi: 10.4161/epi.27906. Epub 2014 Feb 19.

PMID:
24496381
[PubMed - in process]
9.

Regulation of the apolipoprotein gene cluster by a long noncoding RNA.

Halley P, Kadakkuzha BM, Faghihi MA, Magistri M, Zeier Z, Khorkova O, Coito C, Hsiao J, Lawrence M, Wahlestedt C.

Cell Rep. 2014 Jan 16;6(1):222-30. doi: 10.1016/j.celrep.2013.12.015. Epub 2014 Jan 2.

PMID:
24388749
[PubMed - indexed for MEDLINE]
Free Article
10.

Oligonucleotides for upregulating gene expression.

Khorkova O, Hsiao J, Wahlestedt C.

Pharm Pat Anal. 2013 Mar;2(2):215-29. doi: 10.4155/ppa.13.4. Review.

PMID:
24237027
[PubMed - indexed for MEDLINE]
11.

Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome.

Pastori C, Peschansky VJ, Barbouth D, Mehta A, Silva JP, Wahlestedt C.

Hum Genet. 2014 Jan;133(1):59-67. doi: 10.1007/s00439-013-1356-6. Epub 2013 Sep 5.

PMID:
24005575
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Epigenetic pathways and glioblastoma treatment.

Clarke J, Penas C, Pastori C, Komotar RJ, Bregy A, Shah AH, Wahlestedt C, Ayad NG.

Epigenetics. 2013 Aug;8(8):785-95. doi: 10.4161/epi.25440. Epub 2013 Jun 27. Review.

PMID:
23807265
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.

Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ.

Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656.

PMID:
23740899
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Targeting long non-coding RNA to therapeutically upregulate gene expression.

Wahlestedt C.

Nat Rev Drug Discov. 2013 Jun;12(6):433-46. doi: 10.1038/nrd4018. Review. Erratum in: Nat Rev Drug Discov. 2014 Jan;13(1):79.

PMID:
23722346
[PubMed - indexed for MEDLINE]
15.

Personalized medicine in psychiatry: problems and promises.

Ozomaro U, Wahlestedt C, Nemeroff CB.

BMC Med. 2013 May 16;11:132. doi: 10.1186/1741-7015-11-132. Review.

PMID:
23680237
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression.

Gidlöf O, van der Brug M, Ohman J, Gilje P, Olde B, Wahlestedt C, Erlinge D.

Blood. 2013 May 9;121(19):3908-17, S1-26. doi: 10.1182/blood-2012-10-461798. Epub 2013 Mar 14.

PMID:
23493781
[PubMed - indexed for MEDLINE]
Free Article
17.

RNAi joins the "Singles Club".

Peschansky VJ, Liang Z, Wahlestedt C.

Mol Ther. 2012 Nov;20(11):2010-1. doi: 10.1038/mt.2012.218. No abstract available.

PMID:
23131851
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells.

St Laurent G, Shtokalo D, Tackett MR, Yang Z, Eremina T, Wahlestedt C, Urcuqui-Inchima S, Seilheimer B, McCaffrey TA, Kapranov P.

BMC Genomics. 2012 Sep 24;13:504. doi: 10.1186/1471-2164-13-504.

PMID:
23006825
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The Emerging Role of Non-Coding RNAs in Drug Addiction.

Sartor GC, St Laurent G 3rd, Wahlestedt C.

Front Genet. 2012 Jun 22;3:106. doi: 10.3389/fgene.2012.00106. eCollection 2012.

PMID:
22737160
[PubMed]
Free PMC Article
20.

Involvement of long noncoding RNAs in diseases affecting the central nervous system.

Pastori C, Wahlestedt C.

RNA Biol. 2012 Jun;9(6):860-70. doi: 10.4161/rna.20482. Epub 2012 Jun 1. Review.

PMID:
22699553
[PubMed - indexed for MEDLINE]
Free PMC Article

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