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Results: 1 to 20 of 218


HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

Khomtchouk BB, Van Booven DJ, Wahlestedt C.

Source Code Biol Med. 2014 Dec 24;9(1):30. doi: 10.1186/s13029-014-0030-2. eCollection 2014.


The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.

Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ.

J Biol Chem. 2014 Dec 19;289(51):35494-502. doi: 10.1074/jbc.M114.595348. Epub 2014 Oct 29.


Emerging treatment strategies for glioblastoma multiforme.

Carlsson SK, Brothers SP, Wahlestedt C.

EMBO Mol Med. 2014 Oct 13;6(11):1359-70. doi: 10.15252/emmm.201302627.


Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs.

Plotkin A, Volmar CH, Wahlestedt C, Ayad N, El-Ashry D.

Breast Cancer Res Treat. 2014 Sep;147(2):249-63. doi: 10.1007/s10549-014-3093-5. Epub 2014 Aug 17.


I-BET151 selectively regulates IL-6 production.

Barrett E, Brothers S, Wahlestedt C, Beurel E.

Biochim Biophys Acta. 2014 Sep;1842(9):1549-55. doi: 10.1016/j.bbadis.2014.05.013. Epub 2014 May 22.


HuD regulates coding and noncoding RNA to induce APP→Aβ processing.

Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, Resnick SM, de Cabo R, Mattson MP, Gorospe M.

Cell Rep. 2014 Jun 12;7(5):1401-9. doi: 10.1016/j.celrep.2014.04.050. Epub 2014 May 22.


Natural antisense transcripts.

Khorkova O, Myers AJ, Hsiao J, Wahlestedt C.

Hum Mol Genet. 2014 Sep 15;23(R1):R54-63. doi: 10.1093/hmg/ddu207. Epub 2014 May 16.


Non-coding RNAs as direct and indirect modulators of epigenetic regulation.

Peschansky VJ, Wahlestedt C.

Epigenetics. 2014 Jan;9(1):3-12. doi: 10.4161/epi.27473. Review.


BET bromodomain proteins are required for glioblastoma cell proliferation.

Pastori C, Daniel M, Penas C, Volmar CH, Johnstone AL, Brothers SP, Graham RM, Allen B, Sarkaria JN, Komotar RJ, Wahlestedt C, Ayad NG.

Epigenetics. 2014 Apr;9(4):611-20. doi: 10.4161/epi.27906. Epub 2014 Feb 19.


Regulation of the apolipoprotein gene cluster by a long noncoding RNA.

Halley P, Kadakkuzha BM, Faghihi MA, Magistri M, Zeier Z, Khorkova O, Coito C, Hsiao J, Lawrence M, Wahlestedt C.

Cell Rep. 2014 Jan 16;6(1):222-30. doi: 10.1016/j.celrep.2013.12.015. Epub 2014 Jan 2.


Oligonucleotides for upregulating gene expression.

Khorkova O, Hsiao J, Wahlestedt C.

Pharm Pat Anal. 2013 Mar;2(2):215-29. doi: 10.4155/ppa.13.4. Review.


Natural antisense transcripts as therapeutic targets.

Halley P, Khorkova O, Wahlestedt C.

Drug Discov Today Ther Strateg. 2013 Fall;10(3):e119-e125. No abstract available.


Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome.

Pastori C, Peschansky VJ, Barbouth D, Mehta A, Silva JP, Wahlestedt C.

Hum Genet. 2014 Jan;133(1):59-67. doi: 10.1007/s00439-013-1356-6. Epub 2013 Sep 5.


Epigenetic pathways and glioblastoma treatment.

Clarke J, Penas C, Pastori C, Komotar RJ, Bregy A, Shah AH, Wahlestedt C, Ayad NG.

Epigenetics. 2013 Aug;8(8):785-95. doi: 10.4161/epi.25440. Epub 2013 Jun 27. Review.


Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.

Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ.

Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656.


Targeting long non-coding RNA to therapeutically upregulate gene expression.

Wahlestedt C.

Nat Rev Drug Discov. 2013 Jun;12(6):433-46. doi: 10.1038/nrd4018. Review. Erratum in: Nat Rev Drug Discov. 2014 Jan;13(1):79.


Personalized medicine in psychiatry: problems and promises.

Ozomaro U, Wahlestedt C, Nemeroff CB.

BMC Med. 2013 May 16;11:132. doi: 10.1186/1741-7015-11-132. Review.


Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression.

Gidlöf O, van der Brug M, Ohman J, Gilje P, Olde B, Wahlestedt C, Erlinge D.

Blood. 2013 May 9;121(19):3908-17, S1-26. doi: 10.1182/blood-2012-10-461798. Epub 2013 Mar 14.


RNAi joins the "Singles Club".

Peschansky VJ, Liang Z, Wahlestedt C.

Mol Ther. 2012 Nov;20(11):2010-1. doi: 10.1038/mt.2012.218. No abstract available.


Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells.

St Laurent G, Shtokalo D, Tackett MR, Yang Z, Eremina T, Wahlestedt C, Urcuqui-Inchima S, Seilheimer B, McCaffrey TA, Kapranov P.

BMC Genomics. 2012 Sep 24;13:504. doi: 10.1186/1471-2164-13-504.

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