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A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.

Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A.

Mol Immunol. 2015 Mar;64(1):170-6. doi: 10.1016/j.molimm.2014.11.010. Epub 2014 Dec 19.


An update on the thrombotic microangiopathies hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP).

Riedl M, Orth-Höller D, Würzner R.

Semin Thromb Hemost. 2014 Jun;40(4):413-5. doi: 10.1055/s-0034-1376521. Epub 2014 Jun 9. No abstract available.


Treatment of enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome (eHUS).

Würzner R, Riedl M, Rosales A, Orth-Höller D.

Semin Thromb Hemost. 2014 Jun;40(4):508-16. doi: 10.1055/s-0034-1375298. Epub 2014 May 6. Review.


Role of complement in enterohemorrhagic Escherichia coli-Induced hemolytic uremic syndrome.

Orth-Höller D, Würzner R.

Semin Thromb Hemost. 2014 Jun;40(4):503-7. doi: 10.1055/s-0034-1375295. Epub 2014 May 5. Review.


Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.

Dettmar AK, Binder E, Greiner FR, Liebau MC, Kurschat CE, Jungraithmayr TC, Saleem MA, Schmitt CP, Feifel E, Orth-Höller D, Kemper MJ, Pepys M, Würzner R, Oh J.

Infect Immun. 2014 May;82(5):1872-9. doi: 10.1128/IAI.01591-14. Epub 2014 Feb 24.


Compound heterozygous mutations in the C6 gene of a child with recurrent infections.

Westra D, Kurvers RA, van den Heuvel LP, Würzner R, Hoppenreijs EP, van der Flier M, van de Kar NC, Warris A.

Mol Immunol. 2014 Apr;58(2):201-5. doi: 10.1016/j.molimm.2013.11.023. Epub 2013 Dec 30.


Interaction of Shiga toxin 2 with complement regulators of the factor H protein family.

Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R.

Mol Immunol. 2014 Mar;58(1):77-84. doi: 10.1016/j.molimm.2013.11.009. Epub 2013 Dec 5.


Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto's thyroiditis.

Prelog M, Schönlaub J, Würzner R, Koppelstaetter C, Almanzar G, Brunner A, Gasser M, Prommegger R, Häusler G, Kapelari K, Högler W.

BMC Endocr Disord. 2013 Sep 5;13:34. doi: 10.1186/1472-6823-13-34.


Virulence and thrombocyte affectation of two Aspergillus terreus isolates differing in amphotericin B susceptibility.

Speth C, Blum G, Hagleitner M, Hörtnagl C, Pfaller K, Posch B, Ott HW, Würzner R, Lass-Flörl C, Rambach G.

Med Microbiol Immunol. 2013 Oct;202(5):379-89. doi: 10.1007/s00430-013-0300-7. Epub 2013 May 31.


Shiga toxin 2 reduces complement inhibitor CD59 expression on human renal tubular epithelial and glomerular endothelial cells.

Ehrlenbach S, Rosales A, Posch W, Wilflingseder D, Hermann M, Brockmeyer J, Karch H, Satchell SC, Würzner R, Orth-Höller D.

Infect Immun. 2013 Aug;81(8):2678-85. doi: 10.1128/IAI.01079-12. Epub 2013 May 20.


Reduced varicella-zoster-virus (VZV)-specific lymphocytes and IgG antibody avidity in solid organ transplant recipients.

Prelog M, Schönlaub J, Jeller V, Almanzar G, Höfner K, Gruber S, Eiwegger T, Würzner R.

Vaccine. 2013 May 7;31(20):2420-6. doi: 10.1016/j.vaccine.2013.03.058. Epub 2013 Apr 10.


The impact of Rotavirus mass vaccination on hospitalization rates, nosocomial Rotavirus gastroenteritis and secondary blood stream infections.

Zlamy M, Kofler S, Orth D, Würzner R, Heinz-Erian P, Streng A, Prelog M.

BMC Infect Dis. 2013 Mar 1;13:112. doi: 10.1186/1471-2334-13-112.


Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

Clark SJ, Ridge LA, Herbert AP, Hakobyan S, Mulloy B, Lennon R, Würzner R, Morgan BP, Uhrín D, Bishop PN, Day AJ.

J Immunol. 2013 Mar 1;190(5):2049-57. doi: 10.4049/jimmunol.1201751. Epub 2013 Jan 30.


Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome.

Hofer J, Janecke AR, Zimmerhackl LB, Riedl M, Rosales A, Giner T, Cortina G, Haindl CJ, Petzelberger B, Pawlik M, Jeller V, Vester U, Gadner B, van Husen M, Moritz ML, Würzner R, Jungraithmayr T; German-Austrian HUS Study Group.

Clin J Am Soc Nephrol. 2013 Mar;8(3):407-15. doi: 10.2215/CJN.01260212. Epub 2012 Dec 14.


[ESBL-producing E. coli and EHEC in dogs and cats in the Tyrol as possible source of human infection].

Franiek N, Orth D, Grif K, Ewers C, Wieler LH, Thalhammer JG, Würzner R.

Berl Munch Tierarztl Wochenschr. 2012 Nov-Dec;125(11-12):469-75. German.


Aspergillus fumigatus activates thrombocytes by secretion of soluble compounds.

Speth C, Hagleitner M, Ott HW, Würzner R, Lass-Flörl C, Rambach G.

J Infect Dis. 2013 Mar 1;207(5):823-33. doi: 10.1093/infdis/jis743. Epub 2012 Dec 7.


Genetic characterization of Panton-Valentine leukocidin-producing methicillin-resistant Staphylococcus aureus in Western Austria.

Berktold M, Grif K, Mäser M, Witte W, Würzner R, Orth-Höller D.

Wien Klin Wochenschr. 2012 Oct;124(19-20):709-15. doi: 10.1007/s00508-012-0244-8. Epub 2012 Sep 28.


Complement component C5 and C6 mutation screening indicated in meningococcal disease in South Africa.

Owen EP, Leisegang F, Whitelaw A, Simpson J, Baker S, Würzner R, Potter P, Orren A.

S Afr Med J. 2012 May 23;102(6):525-7.


Rapid detection of bloodstream pathogens by real-time PCR in patients with sepsis.

Grif K, Fille M, Würzner R, Weiss G, Lorenz I, Gruber G, Eschertzhuber S, Nachbaur D, Lass-Flörl C, Orth D.

Wien Klin Wochenschr. 2012 Apr;124(7-8):266-70. doi: 10.1007/s00508-012-0159-4. Epub 2012 Apr 14.


Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae.

Rosales A, Hofer J, Zimmerhackl LB, Jungraithmayr TC, Riedl M, Giner T, Strasak A, Orth-Höller D, Würzner R, Karch H; German-Austrian HUS Study Group.

Clin Infect Dis. 2012 May;54(10):1413-21. doi: 10.1093/cid/cis196. Epub 2012 Mar 12.

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