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Results: 1 to 20 of 123

1.

Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.

Finlay D, Vamos M, González-López M, Ardecky RJ, Ganji SR, Yuan H, Su Y, Cooley TR, Hauser CT, Welsh K, Reed JC, Cosford ND, Vuori K.

Mol Cancer Ther. 2014 Jan;13(1):5-15. doi: 10.1158/1535-7163.MCT-13-0153. Epub 2013 Nov 5.

PMID:
24194568
[PubMed - in process]
2.

Targeted treatment with a combination of traditional DMARDs produces excellent clinical and radiographic long-term outcomes in early rheumatoid arthritis regardless of initial infliximab. The 5-year follow-up results of a randomised clinical trial, the NEO-RACo trial.

Rantalaiho V, Kautiainen H, Korpela M, Hannonen P, Kaipiainen-Seppänen O, Möttönen T, Kauppi M, Karjalainen A, Laiho K, Laasonen L, Hakola M, Peltomaa R, Leirisalo-Repo M; for the NEO-RACo Study Group.

Ann Rheum Dis. 2013 Oct 28. doi: 10.1136/annrheumdis-2013-203497. [Epub ahead of print]

PMID:
23908187
[PubMed - as supplied by publisher]
3.

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.

Ardecky RJ, Welsh K, Finlay D, Lee PS, González-López M, Ganji SR, Ravanan P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4253-7. doi: 10.1016/j.bmcl.2013.04.096. Epub 2013 May 14.

PMID:
23743278
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

EGFRvIII stimulates glioma growth and invasion through PKA-dependent serine phosphorylation of Dock180.

Feng H, Hu B, Vuori K, Sarkaria JN, Furnari FB, Cavenee WK, Cheng SY.

Oncogene. 2014 May 8;33(19):2504-12. doi: 10.1038/onc.2013.198. Epub 2013 Jun 3.

PMID:
23728337
[PubMed - indexed for MEDLINE]
5.

Transcription and redox enzyme activities: comparison of equilibrium and disequilibrium levels in the three-spined stickleback.

Nikinmaa M, McCairns RJ, Nikinmaa MW, Vuori KA, Kanerva M, Leinonen T, Primmer CR, Merilä J, Leder EH.

Proc Biol Sci. 2013 Jan 30;280(1755):20122974. doi: 10.1098/rspb.2012.2974. Print 2013 Mar 22.

PMID:
23363636
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.

Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND.

ACS Chem Biol. 2013 Apr 19;8(4):725-32. doi: 10.1021/cb3005512. Epub 2013 Feb 5.

PMID:
23323685
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Stock-specific variation of trophic position, diet and environmental stress markers in Atlantic salmon Salmo salar during feeding migrations in the Baltic Sea.

Vuori K, Kiljunen M, Kanerva M, Koljonen ML, Nikinmaa M.

J Fish Biol. 2012 Nov;81(6):1815-33. doi: 10.1111/j.1095-8649.2012.03386.x. Epub 2012 Sep 27.

PMID:
23130685
[PubMed - indexed for MEDLINE]
8.

Infliximab for 6 months added on combination therapy in early rheumatoid arthritis: 2-year results from an investigator-initiated, randomised, double-blind, placebo-controlled study (the NEO-RACo Study).

Leirisalo-Repo M, Kautiainen H, Laasonen L, Korpela M, Kauppi MJ, Kaipiainen-Seppänen O, Luosujärvi R, Luukkainen R, Karjalainen A, Blåfield H, Uutela T, Ilva K, Julkunen HA, Paimela L, Puolakka K, Moilanen E, Hannonen PJ, Möttönen T; NEO-RACo Study Group.

Ann Rheum Dis. 2013 Jun;72(6):851-7. doi: 10.1136/annrheumdis-2012-201365. Epub 2012 Jun 30.

PMID:
22753402
[PubMed - indexed for MEDLINE]
9.

Integrin signaling in cancer cell survival and chemoresistance.

Aoudjit F, Vuori K.

Chemother Res Pract. 2012;2012:283181. doi: 10.1155/2012/283181. Epub 2012 Apr 11.

PMID:
22567280
[PubMed]
Free PMC Article
10.

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis.

Feng H, Hu B, Jarzynka MJ, Li Y, Keezer S, Johns TG, Tang CK, Hamilton RL, Vuori K, Nishikawa R, Sarkaria JN, Fenton T, Cheng T, Furnari FB, Cavenee WK, Cheng SY.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3018-23. doi: 10.1073/pnas.1121457109. Epub 2012 Feb 7.

PMID:
22323579
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.

Feng H, Hu B, Liu KW, Li Y, Lu X, Cheng T, Yiin JJ, Lu S, Keezer S, Fenton T, Furnari FB, Hamilton RL, Vuori K, Sarkaria JN, Nagane M, Nishikawa R, Cavenee WK, Cheng SY.

J Clin Invest. 2011 Dec;121(12):4670-84. doi: 10.1172/JCI58559. Epub 2011 Nov 14.

PMID:
22080864
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The docking protein p130Cas regulates cell sensitivity to proteasome inhibition.

Zhao M, Vuori K.

BMC Biol. 2011 Oct 28;9:73. doi: 10.1186/1741-7007-9-73.

PMID:
22034875
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

González-López M, Welsh K, Finlay D, Ardecky RJ, Ganji SR, Su Y, Yuan H, Teriete P, Mace PD, Riedl SJ, Vuori K, Reed JC, Cosford ND.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4332-6. doi: 10.1016/j.bmcl.2011.05.049. Epub 2011 May 24.

PMID:
21680182
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antagonists of IAP-family anti-apoptotic proteins - Probe 2.

Lopez M, Welsh K, Yuan H, Stonich D, Su Y, Garcia X, Cuddy M, Houghten R, Sergienko E, Reed JC, Ardecky R, Reddy S, Finlay D, Vuori K, Dad S, Chung TDY, Cosford NDP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Sep 1 [updated 2011 Feb 10].

PMID:
21634080
[PubMed]
Books & Documents
15.

Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

Finlay D, Richardson RD, Landberg LK, Howes AL, Vuori K.

PLoS One. 2010 Oct 12;5(10):e13375. doi: 10.1371/journal.pone.0013375.

PMID:
20967281
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Long-term trends and variation of acidity, COD(Mn) and colour in coastal rivers of Western Finland in relation to climate and hydrology.

Saarinen T, Vuori KM, Alasaarela E, Kløve B.

Sci Total Environ. 2010 Oct 1;408(21):5019-27. doi: 10.1016/j.scitotenv.2010.07.009. Epub 2010 Aug 11. Erratum in: Sci Total Environ. 2013 Feb 1;444:430-2.

PMID:
20705330
[PubMed - indexed for MEDLINE]
17.

Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial.

Rantalaiho V, Korpela M, Laasonen L, Kautiainen H, Järvenpää S, Hannonen P, Leirisalo-Repo M, Blåfield H, Puolakka K, Karjalainen A, Möttönen T; FIN-RACo Trial Group.

Arthritis Res Ther. 2010;12(3):R122. doi: 10.1186/ar3060. Epub 2010 Jun 24.

PMID:
20576092
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Renal safety of initial combination versus single DMARD therapy in patients with early rheumatoid arthritis: an 11-year experience from the FIN-RACo Trial.

Karstila KL, Rantalaiho VM, Mustonen JT, Möttönen TT, Hannonen PJ, Leirisalo-Repo M, Kaipiainen-Seppänen OA, Karjalainen AH, Korpela MM; FIN-RACo Trial Group.

Clin Exp Rheumatol. 2010 Jan-Feb;28(1):73-8.

PMID:
20346242
[PubMed - indexed for MEDLINE]
19.

Molecular markers of yolk sac fry development in nine families of lake trout.

Vuori KA, Paavilainen T, Nikinmaa M, Czesny S, Rinchard J.

J Aquat Anim Health. 2009 Dec;21(4):279-89. doi: 10.1577/H08-001.1.

PMID:
20218502
[PubMed - indexed for MEDLINE]
20.

Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).

Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Côté JF, Liddington RC.

J Biol Chem. 2010 Apr 23;285(17):13211-22. doi: 10.1074/jbc.M110.102517. Epub 2010 Feb 18.

PMID:
20167601
[PubMed - indexed for MEDLINE]
Free PMC Article

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