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Items: 1 to 20 of 77


Comprehensive transcriptional landscape of aging mouse liver.

White RR, Milholland B, MacRae SL, Lin M, Zheng D, Vijg J.

BMC Genomics. 2015 Nov 5;16(1):899. doi: 10.1186/s12864-015-2061-8.


Development of a Targeted Multi-Disorder High-Throughput Sequencing Assay for the Effective Identification of Disease-Causing Variants.

Delio M, Patel K, Maslov A, Marion RW, McDonald TV, Cadoff EM, Golden A, Greally JM, Vijg J, Morrow B, Montagna C.

PLoS One. 2015 Jul 27;10(7):e0133742. doi: 10.1371/journal.pone.0133742. eCollection 2015.


Genetic evidence for common pathways in human age-related diseases.

Johnson SC, Dong X, Vijg J, Suh Y.

Aging Cell. 2015 Oct;14(5):809-17. doi: 10.1111/acel.12362. Epub 2015 Jun 15.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.


Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns.

Gravina S, Ganapathi S, Vijg J.

Nucleic Acids Res. 2015 Aug 18;43(14):e93. doi: 10.1093/nar/gkv366. Epub 2015 Apr 19.


Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing.

White RR, Milholland B, de Bruin A, Curran S, Laberge RM, van Steeg H, Campisi J, Maslov AY, Vijg J.

Nat Commun. 2015 Apr 10;6:6790. doi: 10.1038/ncomms7790.


Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.

MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD.

Aging Cell. 2015 Apr;14(2):288-91. doi: 10.1111/acel.12314. Epub 2015 Jan 28.


INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform.

Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1053-8. doi: 10.1073/pnas.1418203112. Epub 2014 Dec 30.


Editorial overview: Molecular and genetic bases of disease: the double life of DNA.

McMurray CT, Vijg J.

Curr Opin Genet Dev. 2014 Jun;26:v-vii. doi: 10.1016/j.gde.2014.09.002. Epub 2014 Oct 2.


Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation.

Furgason JM, Li W, Milholland B, Cross E, Li Y, McPherson CM, Warnick RE, Rixe O, Stambrook PJ, Vijg J, Bahassi el M.

Mutagenesis. 2014 Sep;29(5):341-50. doi: 10.1093/mutage/geu026. Epub 2014 Aug 6.


Comparative genetics of longevity and cancer: insights from long-lived rodents.

Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J.

Nat Rev Genet. 2014 Aug;15(8):531-40. doi: 10.1038/nrg3728. Epub 2014 Jul 1. Review.


The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.

Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, de With P, de Bruin A, Hoeijmakers JH, Vijg J, van Steeg H, Hasty P.

PLoS One. 2014 Apr 16;9(4):e93568. doi: 10.1371/journal.pone.0093568. eCollection 2014.


Innovating aging: promises and pitfalls on the road to life extension.

Vijg J, de Grey AD.

Gerontology. 2014;60(4):373-80. doi: 10.1159/000357670. Epub 2014 Apr 9.


Genome-wide quantitative analysis of DNA methylation from bisulfite sequencing data.

Akman K, Haaf T, Gravina S, Vijg J, Tresch A.

Bioinformatics. 2014 Jul 1;30(13):1933-4. doi: 10.1093/bioinformatics/btu142. Epub 2014 Mar 10.


Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P.

PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014.


Aging on a different scale--chronological versus pathology-related aging.

Melis JP, Jonker MJ, Vijg J, Hoeijmakers JH, Breit TM, van Steeg H.

Aging (Albany NY). 2013 Oct;5(10):782-8.


Myc-dependent genome instability and lifespan in Drosophila.

Greer C, Lee M, Westerhof M, Milholland B, Spokony R, Vijg J, Secombe J.

PLoS One. 2013 Sep 6;8(9):e74641. doi: 10.1371/journal.pone.0074641. eCollection 2013.


High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.

Gravina S, Dollé ME, Wang T, van Steeg H, Hasty P, Hoeijmakers J, Vijg J.

PLoS One. 2013 Sep 9;8(9):e73496. doi: 10.1371/journal.pone.0073496. eCollection 2013.


Fast mitochondrial DNA isolation from mammalian cells for next-generation sequencing.

Quispe-Tintaya W, White RR, Popov VN, Vijg J, Maslov AY.

Biotechniques. 2013 Sep;55(3):133-6. doi: 10.2144/000114077.


Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes.

Garagnani P, Giuliani C, Pirazzini C, Olivieri F, Bacalini MG, Ostan R, Mari D, Passarino G, Monti D, Bonfigli AR, Boemi M, Ceriello A, Genovese S, Sevini F, Luiselli D, Tieri P, Capri M, Salvioli S, Vijg J, Suh Y, Delledonne M, Testa R, Franceschi C.

Aging (Albany NY). 2013 May;5(5):373-85.

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