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Results: 1 to 20 of 22

1.

Total synthesis of zyzzyanones A-D.

Nadkarni DH, Murugesan S, Velu SE.

Tetrahedron. 2013 May 20;69(20):4105-4113.

PMID:
23956468
[PubMed]
Free PMC Article
2.

Identification of the ZAK-MKK4-JNK-TGFβ signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ.

Chen D, Wang W, Qin JJ, Wang MH, Murugesan S, Nadkarni DH, Velu SE, Wang H, Zhang R.

Curr Cancer Drug Targets. 2013 Jul;13(6):651-60.

PMID:
23607596
[PubMed - indexed for MEDLINE]
3.

Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression.

Keeling KM, Wang D, Dai Y, Murugesan S, Chenna B, Clark J, Belakhov V, Kandasamy J, Velu SE, Baasov T, Bedwell DM.

PLoS One. 2013 Apr 10;8(4):e60478. doi: 10.1371/journal.pone.0060478. Print 2013.

PMID:
23593225
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mini-review: bmx kinase inhibitors for cancer therapy.

Jarboe JS, Dutta S, Velu SE, Willey CD.

Recent Pat Anticancer Drug Discov. 2013 Sep;8(3):228-38. Review.

PMID:
23198769
[PubMed - indexed for MEDLINE]
5.

Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog.

Zhang X, Xu H, Zhang X, Voruganti S, Murugesan S, Nadkarni DH, Velu SE, Wang MH, Wang W, Zhang R.

Mar Drugs. 2012 May;10(5):1138-55. doi: 10.3390/md10051138. Epub 2012 May 23.

PMID:
22822362
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action.

Chen T, Xu Y, Guo H, Liu Y, Hu P, Yang X, Li X, Ge S, Velu SE, Nadkarni DH, Wang W, Zhang R, Wang H.

PLoS One. 2011;6(6):e20729. doi: 10.1371/journal.pone.0020729. Epub 2011 Jun 6.

PMID:
21673964
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Elevated levels of NO are localized to distal airways in asthma.

Anderson JT, Zeng M, Li Q, Stapley R, Moore DR 2nd, Chenna B, Fineberg N, Zmijewski J, Eltoum IE, Siegal GP, Gaggar A, Barnes S, Velu SE, Thannickal VJ, Abraham E, Patel RP, Lancaster JR Jr, Chaplin DD, Dransfield MT, Deshane JS.

Free Radic Biol Med. 2011 Jun 1;50(11):1679-88. doi: 10.1016/j.freeradbiomed.2011.03.015. Epub 2011 Mar 16. Erratum in: Free Radic Biol Med. 2013 May;58:45.

PMID:
21419218
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice.

Li H, Ezell SJ, Zhang X, Wang W, Xu H, Rayburn ER, Zhang X, Gurpinar E, Yang X, Sommers CI, Velu SE, Zhang R.

Biomed Chromatogr. 2011 May;25(5):628-34. doi: 10.1002/bmc.1498. Epub 2010 Sep 15.

PMID:
20845374
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent.

Ezell SJ, Li H, Xu H, Zhang X, Gurpinar E, Zhang X, Rayburn ER, Sommers CI, Yang X, Velu SE, Wang W, Zhang R.

Mar Drugs. 2010 Jul 13;8(7):2129-41. doi: 10.3390/md8072129.

PMID:
20714427
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors.

Chenna BC, King JR, Shinkre BA, Glover AL, Lucius AL, Velu SE.

Eur J Med Chem. 2010 Sep;45(9):3752-61. doi: 10.1016/j.ejmech.2010.05.024. Epub 2010 May 20.

PMID:
20541848
[PubMed - indexed for MEDLINE]
11.

Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Schormann N, Velu SE, Murugesan S, Senkovich O, Walker K, Chenna BC, Shinkre B, Desai A, Chattopadhyay D.

Bioorg Med Chem. 2010 Jun 1;18(11):4056-66. doi: 10.1016/j.bmc.2010.04.020. Epub 2010 Apr 9.

PMID:
20452776
[PubMed - indexed for MEDLINE]
12.

A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action.

Wang W, Rayburn ER, Velu SE, Chen D, Nadkarni DH, Murugesan S, Chen D, Zhang R.

Breast Cancer Res Treat. 2010 Sep;123(2):321-31. doi: 10.1007/s10549-009-0638-0. Epub 2009 Nov 21.

PMID:
19936915
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues.

Wang W, Rayburn ER, Velu SE, Nadkarni DH, Murugesan S, Zhang R.

Clin Cancer Res. 2009 May 15;15(10):3511-8. doi: 10.1158/1078-0432.CCR-08-2689.

PMID:
19451594
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synthesis and in vitro anti-lung cancer activity of novel 1, 3, 4, 8-tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogs.

Nadkarni DH, Wang F, Wang W, Rayburn ER, Ezell SJ, Murugesan S, Velu SE, Zhang R.

Med Chem. 2009 May;5(3):227-36.

PMID:
19442212
[PubMed - indexed for MEDLINE]
15.

FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer.

Wang F, Ezell SJ, Zhang Y, Wang W, Rayburn ER, Nadkarni DH, Murugesan S, Velu SE, Zhang R.

Invest New Drugs. 2010 Jun;28(3):234-41. doi: 10.1007/s10637-009-9232-x. Epub 2009 Mar 10.

PMID:
19274441
[PubMed - indexed for MEDLINE]
16.

Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines.

Shinkre BA, Raisch KP, Fan L, Velu SE.

Bioorg Med Chem. 2008 Mar 1;16(5):2541-9. Epub 2007 Nov 28.

PMID:
18093835
[PubMed - indexed for MEDLINE]
17.

Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A.

Chenna BC, Shinkre BA, King JR, Lucius AL, Narayana SV, Velu SE.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):380-5. Epub 2007 Oct 18.

PMID:
18023345
[PubMed - indexed for MEDLINE]
18.

Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.

Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ.

J Med Chem. 2007 May 31;50(11):2612-21. Epub 2007 May 10.

PMID:
17489580
[PubMed - indexed for MEDLINE]
19.

Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity.

Shinkre BA, Raisch KP, Fan L, Velu SE.

Bioorg Med Chem Lett. 2007 May 15;17(10):2890-3. Epub 2007 Feb 25.

PMID:
17368022
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library.

Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ.

J Comb Chem. 2005 Nov-Dec;7(6):898-904.

PMID:
16283799
[PubMed - indexed for MEDLINE]

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