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Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin.

Nijampatnam B, Dutta S, Velu SE.

Chin J Nat Med. 2015 Aug;13(8):561-77. doi: 10.1016/S1875-5364(15)30052-2. Review.


Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats.

Yu JX, Voruganti S, Li DD, Qin JJ, Nag S, Xu S, Velu SE, Wang W, Zhang R.

Chin J Nat Med. 2015 Jul;13(7):554-60. doi: 10.1016/S1875-5364(15)30051-0.


New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans.

Zhang Q, Nguyen T, McMichael M, Velu SE, Zou J, Zhou X, Wu H.

Int J Antimicrob Agents. 2015 Aug;46(2):174-82. doi: 10.1016/j.ijantimicag.2015.03.015. Epub 2015 May 8.


Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor.

Singh T, Gupta NA, Xu S, Prasad R, Velu SE, Katiyar SK.

Oncotarget. 2015 Aug 28;6(25):21268-82.


A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms.

Vayalil PK, Oh JY, Zhou F, Diers AR, Smith MR, Golzarian H, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A.

PLoS One. 2015 Mar 18;10(3):e0120460. doi: 10.1371/journal.pone.0120460. eCollection 2015.


Total Synthesis of Calothrixins A and B via Oxidative Radical Reaction of Cyclohexenone with Aminophenanthridinedione.

Xu S, Nguyen T, Pomilio I, Vitale MC, Velu SE.

Tetrahedron. 2014 Sep 2;70(35):5928-5933.


Antibacterial and Antibiofilm Activities of Makaluvamine Analogs.

Nijampatnam B, Nadkarni DH, Wu H, Velu SE.

Microorganisms. 2014;2(3):128-139.


Total synthesis of zyzzyanones A-D.

Nadkarni DH, Murugesan S, Velu SE.

Tetrahedron. 2013 May 20;69(20):4105-4113.


Identification of the ZAK-MKK4-JNK-TGFβ signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ.

Chen D, Wang W, Qin JJ, Wang MH, Murugesan S, Nadkarni DH, Velu SE, Wang H, Zhang R.

Curr Cancer Drug Targets. 2013 Jul;13(6):651-60.


Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression.

Keeling KM, Wang D, Dai Y, Murugesan S, Chenna B, Clark J, Belakhov V, Kandasamy J, Velu SE, Baasov T, Bedwell DM.

PLoS One. 2013 Apr 10;8(4):e60478. doi: 10.1371/journal.pone.0060478. Print 2013.


Mini-review: bmx kinase inhibitors for cancer therapy.

Jarboe JS, Dutta S, Velu SE, Willey CD.

Recent Pat Anticancer Drug Discov. 2013 Sep;8(3):228-38. Review.


Preclinical evaluation of anticancer efficacy and pharmacological properties of FBA-TPQ, a novel synthetic makaluvamine analog.

Zhang X, Xu H, Zhang X, Voruganti S, Murugesan S, Nadkarni DH, Velu SE, Wang MH, Wang W, Zhang R.

Mar Drugs. 2012 May;10(5):1138-55. doi: 10.3390/md10051138. Epub 2012 May 23.


Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action.

Chen T, Xu Y, Guo H, Liu Y, Hu P, Yang X, Li X, Ge S, Velu SE, Nadkarni DH, Wang W, Zhang R, Wang H.

PLoS One. 2011;6(6):e20729. doi: 10.1371/journal.pone.0020729. Epub 2011 Jun 6.


Elevated levels of NO are localized to distal airways in asthma.

Anderson JT, Zeng M, Li Q, Stapley R, Moore DR 2nd, Chenna B, Fineberg N, Zmijewski J, Eltoum IE, Siegal GP, Gaggar A, Barnes S, Velu SE, Thannickal VJ, Abraham E, Patel RP, Lancaster JR Jr, Chaplin DD, Dransfield MT, Deshane JS.

Free Radic Biol Med. 2011 Jun 1;50(11):1679-88. doi: 10.1016/j.freeradbiomed.2011.03.015. Epub 2011 Mar 16. Erratum in: Free Radic Biol Med. 2013 May;58:45.


Development and validation of an HPLC method for quantitation of BA-TPQ, a novel iminoquinone anticancer agent, and an initial pharmacokinetic study in mice.

Li H, Ezell SJ, Zhang X, Wang W, Xu H, Rayburn ER, Zhang X, Gurpinar E, Yang X, Sommers CI, Velu SE, Zhang R.

Biomed Chromatogr. 2011 May;25(5):628-34. doi: 10.1002/bmc.1498. Epub 2010 Sep 15.


Preclinical pharmacology of BA-TPQ, a novel synthetic iminoquinone anticancer agent.

Ezell SJ, Li H, Xu H, Zhang X, Gurpinar E, Zhang X, Rayburn ER, Sommers CI, Yang X, Velu SE, Wang W, Zhang R.

Mar Drugs. 2010 Jul 13;8(7):2129-41. doi: 10.3390/md8072129.


Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors.

Chenna BC, King JR, Shinkre BA, Glover AL, Lucius AL, Velu SE.

Eur J Med Chem. 2010 Sep;45(9):3752-61. doi: 10.1016/j.ejmech.2010.05.024. Epub 2010 May 20.


Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.

Schormann N, Velu SE, Murugesan S, Senkovich O, Walker K, Chenna BC, Shinkre B, Desai A, Chattopadhyay D.

Bioorg Med Chem. 2010 Jun 1;18(11):4056-66. doi: 10.1016/j.bmc.2010.04.020. Epub 2010 Apr 9.


A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action.

Wang W, Rayburn ER, Velu SE, Chen D, Nadkarni DH, Murugesan S, Chen D, Zhang R.

Breast Cancer Res Treat. 2010 Sep;123(2):321-31. doi: 10.1007/s10549-009-0638-0. Epub 2009 Nov 21.


A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids.

Murugesan S, Nadkarni DH, Velu SE.

Tetrahedron Lett. 2009 Jun 24;50(25):3074-3076.

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