Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
N Engl J Med. 2012 Apr 12;366(15):1404-13. doi: 10.1056/NEJMoa1200933. Epub 2012 Mar 24.

Vorapaxar in the secondary prevention of atherothrombotic events.

Collaborators (2178)

Braunwald E, Morrow DA, Scirica BM, Bonaca MP, McCabe CH, Morin S, Fish P, Lamp J, Gershman E, Murphy S, Deenadayalu N, Skene A, Hill K, Bennett L, Strony J, Plat F, Berman G, Lipka L, Kilian A, He W, Liu X, Fox KA, Aylward P, Bassand JP, Betriu A, Bounameaux H, Corbalan R, Creager M, Dalby A, De Ferrari G, Dellborg M, Diehm CH, Dietz R, Goto S, Grande P, Gurbel P, Hankey G, Isaza D, Jensen P, Kiss R, Lewis B, Merlini P, Moliterno D, Morais J, Nicolau JC, Nieminen M, Nilsen D, Olin J, Ophuis TO, Paolasso E, Pichler M, Shinohara Y, Spinar J, Teal P, Tendera M, Theroux P, Thomassen L, Van de Werf F, White H, Wilcox R, Alberts M, Ameriso S, Diener H, Mohr J, Welch M, Wiviott SD, Awtry E, Berger C, Desai A, Gelfand E, Ho C, Leeman D, Link M, Norden A, Pande A, Rost N, Ruberg R, Silverman S, Singhal A, Vita J, Frye RL, Bailey KR, Easton J, Hochman J, Steg PG, Verheught F, Lee K, Ameriso S, Paolasso E, Mauro DO, Centurion A, Carlevaro O, Cardozo E, Cartasegna L, Soccini N, Farras HA, Molina Aguirre E, Duronto E, Arrechavala L, Rey R, Stilman A, Fernández H, Marinsalta G, Tartaglione J, Chekherdemian M, Povedano G, Casares E, Kantor P, Reges P, Cuneo C, Martinez G, MacKinnon I, Bagnato B, Fernandez A, Funosas C, Lozada A, Barilati P, Ferrari J, Ferrari N, Llanos J, Casaccia G, Giannaula R, García Méndez C, Cirio J, García Dávila C, Estol C, Chiezzo D, Ameriso S, Ramirez J, Garrido S, López M, Hominal M, Bianchini MV, Ramos M, Verdini E, Herrera G, Monne H, Ioli P, Samudio MA, Rotta Escalante R, Tarulla A, Reich E, Perez G, Milesi R, Berli M, Marino J, Funes I, Prado A, Bezi M, Fernandez R, Rojas M, Cimbaro Canella JP, Galarza Salazan M, Aylward P, Hankey G, Chew D, Horsfall L, Hankey G, Claxton A, French J, O'Brien K, Nelson G, Loxton A, McCann A, Downey C, Aroney C, Cleave P, Worthley S, Roach A, Amerena J, Long A, Thompson P, Ferguson L, Fitzpatrick M, Mackenzie M, Youssef G, Goldsmith H, Jayasinghe R, Quinlan S, Arstall M, Rose J, Counsell J, Martin M, Crimmins D, Slattery A, Anderson C, Paraskevaidis T, Davis S, Silver G, Gerraty RP, Gapper J, Donnan G, Petrolo S, Whelan A, Tulloch G, Singh B, Campo Ma, Dick R, Savage C, Hill A, Conway B, Waites J, Keays P, Pichler M, Pichler M, Kopp K, Hainzer D, Podczeck-Schweighofer A, Priesnitz T, Drexel H, Hagspiel V, Foeger B, Hilbe C, Trinka E, Sinadinoska D, Pilger E, Brodmann M, Stöllberger C, Jungbauer LV, Koppensteiner R, Hoke M, Grisold W, Berger O, Gaul GB, Fazekas N, Wandaller C, Stockenhuber F, Rek A, Willeit J, Zangerle A, Kiechl S, Sturm W, Theurl M, Gruber F, Schacherl S, Auer J, Primus C, Eber B, Ammer M, Hofer JF, Mayr H, Moser S, Hoellmueller I, Van der Werf F, Motte S, Jorion M, Schroë H, Zwinnen W, Vermassen F, Geenens M, De Wolf L, Briké C, De Deyn P, Ongena P, De Klippel N, Meeuwissen K, Desfontaines P, Tincani G, Vandermeeren Y, de Fays K, Pandolfo M, Alaerts N, Peeters A, Findik A, Tack P, deGrande E, Thijs V, Marcelis E, Van Landegem W, Vanhagendoren S, Vanhooren G, Schotte V, Celen H, Bes N, De Letter J, Schotte V, Holvoet G, Claerbout B, Verhamme P, Debaveye B, Bourgeois P, Debrabandere K, Stalpaert S, Dhondt E, De Maeseneire S, De Bleecker J, de Koning K, Vincent M, Tahon S, Monté C, Maes J, Vossaert R, Vandenhoven C, Roosen J, Vissers C, Sinnaeve P, de Velder L, Thoeng J, Cauwenberghs J, Deceuninck F, Nicolau J, Ardito WR, Queirantes C, de Araujo Filho JD, Queirantes CS, Ribeiro JP, Guizzardi SP, Chaves ML, Titton NF, Pereira AH, Webber I, da Silva DG Jr, Uehara RM, Brasileiro J, Uehara RM, Maia LN, Souza A, Bodanese LC, Homem R, Friedrich MA, Macagnan AP, Dutra OP, Brum AB, Rossi PR, Herek L, Feitosa GS, Bernardes Ade S, Braga J, Rodrigues D, Guimarães A, Teixeira AB, Marin Neto JA, Tonani M, Piegas LS, Amato V, Leães P, Osorio RL, Ganem F, Vieira AP, Leao P, Kanashiro V, Franken RA, Martins EP, Gagliardi RJ, Silva L, Caffaro RA, Novaes GS, Carvalho A, Laet VL, Miranda F Jr, Crippa BA, Saraiva JF, Ormundo CT, Speciali JG, Guandolini G, de Albuquerque DC, Silva V, Abrantes JA, Pinheiro L, Teixeira MS, Guanaes DF, Resende ES, Andrade SF, Alves ÁR Jr, Oliveira OM, Tauil CB, Araujo E, de Souza J, Araujo E, de Freitas GR, Horokosky AP, Barbosa EC, Muniz P, de Moraes JB Jr, Cabral M, Faria Neto JR, Belemer A, Paiva MS, Brito A, Hernandes ME, Amorim R, Pittella FJ, Brito HH, Teal P, Theroux P, Kouz S, Roy M, Gosselin G, David M, Huynh T, Boudreault C, Heath J, Scott L, Bhargava R, Stafford C, Klinke WP, Martin L, Chan YK, Zaniol D, Rebane T, Abramovich M, Vizel S, Fox B, Kornder J, Breakwell L, Constance C, Gauthier M, Cleveland D, Valley S, Dion D, Morissette A, Vertes G, Ross B, Pandey AS, Byrne M, Abramson B, Sodhi N, Ervin F, Thiessen S, Halperin F, Stedham V, Pesant Y, Sardin V, Saw J, Tarry L, Pouliot J, Marquette S, Belisle P, Gagne D, Ducas J, Munoz A, Sussex B, Newman S, Madan M, Hsu E, Bata I, Cossett J, Glanz A, Vilag C, Paddock V, Collings E, Sabbah E, Chausse I, Fortin C, Lepage C, Chehayeb R, Viau C, Ma P, Seib M, Lamy A, Rizzo A, Rajakumar AR, Eikel L, Nigro F, Stoger S, Welsh R, Lindholm L, Parker JD, Webber S, Winkler L, Hannah G, Gupta M, Kubiak A, Mukherjee A, Bozek B, Nguyen M, Dufort L, Haichin R, Toyota V, Theroux P, Bujold S, Syan G, Chinnasane S, Houde G, Rousseau S, Poirier P, Lariviere M, Dupuis R, Ouimet F, Audet J, Darveau C, Labonte R, Rice T, Nawaz S, Rice T, Cantor W, Robbins K, Boucher P Jr, Roberge J, Zadra R, McPherson C, Corbalan R, Prieto JC, Noriega V, Cereño C, Mestas M, Yovaniniz P, Ferrada W, Pincetti C, Torres G, Perez L, Villan C, Escobar E, Martin R, Corbalan R, Padilla I, Ramirez M, Hormazabal R, Pedemonte O, Suazo E, Hasbun S, Mejias M, Cardenas F, Donoso L, Godoy I, Henriquez P, Mariné L, Vergara T, Juri C, Vergara E, Isaza D, Muñoz M, Solano E, Toro J, Cardenas S, Mendoza F, Martinez S, Saaibi JF, Castillo KM, Ruiz NP, Castillo T, Orozco A, Muñoz C, Martínez J, Lopez D, Ochoa J, Andrade J, Jaramillo C, Garces GP, Botero R, Cáceres A, Jaramillo M, Mejia C, Schlesinger A, Munevar V, Rodriguez J, Granados LM, Jaramillo N, Aristizabal C, Cano N, Salazar JC, Urina M, Manco T, Isaza D, Valenzuela C, Hernandez HJ, Delgado PS, Vagner B, Castaño LA, Ucros P, Tellez M, Delgado JA, Piedrahita CA, Crump J, Fernandez V, Quintero CA, Moreno M, Hernandez Triana E, Cuentas I, Accini JL, Accini M, Manzur F, Rivera E, Reynales H, Huertas D, Spinar J, Hovorka J, Filipovsky J, Hirmerova J, Peska S, Jura R, Kanovsky P, Herzig R, Jansky P, Fiala R, Kalita Z, Gatkova A, Bauer J, Fiksa J, Sedlacek J, Monhart Z, Bren J, Linhart A, Skalicka L, Vitovec J, Hlinomaz O, Spinar J, Parenica J, Soucek M, Rihacek I, Branny M, Sknouril L, Klimsa Z, Holub M, Línkova H, Rektor I, Mikulik R, Mayer O Sr, Novakova B, Bar M, Brodova P, Polasek R, Sabl P, Kos P, Lorenc Z, Lorenc Z, Macel I, Macel I, Grande P, Grande P, Graversen KH, Galatius S, Soderberg LH, Sillesen H, Madelung S, Overgård K, Stan V, Rasmussen LH, Mortensen B, Iversen HK, Back C, Olesen C, Christensen H, Pedersen A, Nielsen T, Hasain M, Tanggaard L, Husted S, Christensen LL, Sillesen H, Haas L, Mickley H, Hosbond S, Rosenlund I, Jepsen J, Kaspersen BB, Bronnum-Schou J, Hempel H, Nyvad O, Feldthaus B, Jensen BS, Jensen MK, Andersen G, Thomsen RB, Rokkedal J, Joergensen A, Bülow M, Jeppesen J, Lederballe O, Scheibel I, Sjol A, Larsen J, Nieminen M, Graner M, Svahn T, Melin J, Kaakkomäki A, Airaksinen J, Vasankari T, Tatlisumak T, Metso M, Remes A, Näppä M, Jäkälä P, Sivenius J, Kalinen M, Roine RO, Ketola R, Bassand JP, Bassand J, Pales D, Coisne D, Berger N, Galinier M, Rosolin N, Elbaz M, Lacassagne L, Montalescot G, Vignolles N, Gully C, Lepage I, Roynard J, Roynard J, Hamon M, Brucato S, Macquin-Mavier I, Beitar T, Berthezene P, Medkour T, Amarenco P, Gueblaoui N, Timsit S, Riou D, Mahagne M, Suissa L, Quere I, Clouzot S, Emmerich J, Martinez I, Moulin T, Cole M, Hosseini H, Monod V, Cottin Y, Bichat F, Galley D, Beltra C, Samson Y, Pires R, Bura-Riviere A, Pelvet B, Giroud M, Lecheneaut C, Ohlmann P, Ait-m-bark Z, Farah B, Petit F, Caussin C, Braun C, Diehm C, Diener H, Mehrhof F, Inkrot S, Darius H, Heinze H, Radke P, Kulikowsky C, Ferrari M, Utschig S, Strasser R, Haacke K, Felix SB, Bruder M, Nienaber C, Pfaff H, Sohn H, Baylacher M, Mudra H, Setzer P, Konstantinides S, Hallmann A, Kreuzer J, Tsoy I, Schneider P, Kreuzer J, Schneider P, Appel KF, Habermeier A, Zeiher AM, Kretschmer T, Mitrovic V, Lehinant S, Bohlscheid V, Palme B, Heuer H, Espinola-Klein C, Savvidis S, Kleinertz K, Hänel J, Schmidt E, Schmidt A, Ringleb PA, Ludwig I, Diener H, Dietzold M, Diehm C, Schaffranka A, Ranft J, Cegla C, Berrouschot J, Stoll A, Tanislav C, Brandtner MA, Rosenkranz M, Otto D, Görtler M, Barleben M, Haberl R, Miedl S, Maschke M, Schröder K, Aral-Becher B, Herzog-Hauff S, Guenther A, Herzau C, Hoffmann U, Roth-Zetzsche S, Grond M, Becker M, Hamann G, Simon K, Köhrmann M, Schmidt A, Glahn J, Wuttig H, Nabavi DG, Seraphin D, Schellong S, Frommhold R, Dichgans M, Doerr A, Blessing E, Buss I, Butter C, Bettin D, Grosch B, Blank E, Wong L, Liu R, Lee S, Kong S, Yu C, So E, Kiss R, Kiss R, Jakal Á, Masszi G, Masszi G, Czuriga I, Czuriga I, Kapocsi J, Soós E, Csiba L, Fekete K, Valikovics A, Valikovics A, Dioszeghy P, Muskóczki E, Csányi A, Csányi A, Matoltsy A, Matoltsy A, Lewis B, Lewis B, Yuval R, Bornstein N, Elimelech R, Chajek-Shaul T, Bursztyn M, Hayek T, Hazbon K, Gavish D, Anat N, Wexler D, Azar P, Mosseri M, Tsirulnikov E, Rozenman Y, Logvinenko S, Tanne D, Don A, Gross B, Feldman Y, Klainman E, Genin-Dmitrishin I, Eldar M, Eizenberg N, Atar S, Lasri E, Hammerman H, Aharoni G, Zimlichman R, Zuker S, Telman G, Afanasiev S, Katz A, Biton A, Goldhaber A, Goldhaber M, Elian D, Linor A, Biton A, Meyuhas S, Tsalihin D, Kissos D, Lampl Y, Israelson M, Gottlieb S, Dotan L, Elis A, Karny M, Hussein O, Shestatski K, Brenner H, Segal E, De Ferrari G, Merlini P, Baldini U, Baldini U, Gavazzi A, Gavazzi A, Poloni M, Censori B, Aiazzi L, Maraglino C, Marenzi G, Marenzi G, Specchia G, Specchia G, Tritto I, Tritto I, Golino P, Golino P, Cianflone D, Cianflone D, Martignoni A, Martignoni A, Tamburino C, Tamburino C, Rubartelli P, Rubartelli P, Ardissino D, Tadonio I, Stramba-Badiale M, Cernuschi P, Nardulli R, Nardulli R, Sommariva L, Sommariva L, Giordano A, Giordano A, Berni A, Berni A, Cavallini C, Cavallini C, Fiscella A, Azzarelli S, Esposito G, Cassese S, Danzi G, Danzi G, Fattore L, Fattore L, Barbieri E, Barbieri E, De Caterina R, De Caterina R, Odero A, Odero A, Puttini M, Puttini M, Corrada E, Monzini N, De Ferrari G, Vadalà A, Pistarini C, Pistarini C, Scrutinio D, Scrutinio D, Ferratini M, Marcheselli S, Moretti L, Partemi L, Pupilella T, Lazzari A, Ledda A, Geraci G, Rasura M, Beccia M, Cassadonte F, Vatrano M, Merlini P, Bongiorni D, Mos L, Marcuzzi G, Murena E, Murena E, Uguccioni L, Ferretti C, Piti A, Piti A, Terrosu P, Terrosu P, Perrone PF, Perrone PF, Marconi R, Grasso L, Severi S, Severi S, Evola R, Russo N, Agnelli G, Agnelli G, Paci C, Paci C, Carugo S, Carugo S, Silvestri O, Silvestri O, Testa R, Novo S, Novo S, Itamoto K, Niinuma Y, Okada Y, Oshiba S, Takano K, Oshiba S, Maruyama J, Kouno M, Nakagawara J, Chiba M, Takeda R, Chiba M, Suzuki A, Segawa M, Nagata K, Segawa M, Ichikawa S, Aoki M, Mihara B, Akuzawa M, Sano M, Ando M, Kotera M, Kurosaki E, Araki N, Oono Y, Takagi S, Nakamura M, Hashimoto K, Hirayama K, Itagaki T, Funama M, Ohta K, Matsumoto M, Sakaida H, Nishimura N, Ino T, Yokoyama M, Okada Y, Asoshima K, Mekaru S, Inafuku N, Iha K, Irei T, Yoshioka K, Hirano Y, Hirokami M, Ito T, Hiraoka Y, Yokoyama M, Nanri K, Takaki M, Adachi T, Wakabayashi K, Hatashita S, Sasaki A, Morioka N, Yukimoto M, Tanahashi N, Kusano S, Nakamura T, Asoshima K, Uchiyama S, Komatsu M, Nakagawa S, Wakabayashi K, Katayama S, Kawano S, Hamanaka I, Honda Y, Kamitani T, Ishigaki C, Taguchi S, Yonezawa E, Ishige N, Tanabe K, Yagi H, Kuroda S, Kanda M, Kanbe T, Sakota S, Hamada M, Yoshioka A, Nagata H, Ishigami M, Takahashi S, Nakagawa H, Honda T, Manabe Y, Nomura T, Chee KH, Loke L, Ong TK, Sekon M, Kandasamy B, Radzali N, Ophuis AO, Hamer B, van Doorn M, Tan T, van der Spoel A, van Stralen R, van der Zeijst M, Dunselman P, Lauwerijssen I, van Dijkman P, de Lange H, Wardeh A, Dille-Amo C, Westendorp P, Stuij S, van Hessen M, Engelen W, Bartels G, Hendriks M, Prins F, Van Gent M, Kuijper A, Schiks M, Römer T, Kerssen E, Ophuis AO, Schut A, Nierop P, Danse I, Leenders C, Swets E, Freericks M, Brilman CF, van Daele M, Bouwens M, Swart H, Meijlis P, van der Zwaan C, Havenaar H, Holwerda N, van de Loo R, Hamraoui K, Dabrowska K, Werner H, Wittekoek M, Ronner E, Dijkshoorn A, Herrman J, Bosman F, Basart D, Scholtze A, Post J, Hendrix H, Troquay R, Daniels R, van den Berg J, van Vemde G, ten Berg J, Helwig J, Schreuder T, Simons T, Groenemeijer B, Mulder R, Heymeriks J, Ketting P, Keizer K, Bongenaar H, Welten R, Dahlmans A, Jukema J, van der Willik E, Smits P, Jones B, White H, White H, Cunningham LP, Scott DS, Eadie P, Hart H, Turner A, Devlin G, Peek D, Tisch J, Arnold W, Hamer A, Tomlinson J, Elliott J, Hume M, Ternouth I, Vickers C, Williams M, Schmid D, Harrison N, Coleman W, O'Meeghan T, Dewar J, Singh GP, Austin S, Nilsen D, Thomassen L, Bonarjee VV, Nilsen JM, Nordrehaug JE, Fålun NB, Opdal A, Birkeland B, Thomassen L, Kaalaas AM, Otterstad JE, Hansen VH, Halvorsen S, Semb GA, Rolstad OJ, Germán M, Gullestad L, Stueflotten W, Larsen T, Skarpenes I, Kontny F, Olsen BB, Graven T, Haug HH, Morsund ÅH, Sivertsen S, Hysing J, Flagstad E, Sirnes PA, Nilsen VV, Indredavik B, Storvold JB, Sætre T, Guevara C, Schüler S, Utvik MS, Sandvik JE, Thunhaug H, Tendera M, Tendera M, Kozakiewicz K, Pluta W, Kania M, Kubica J, Kozinski M, Gil RJ, Pawlak A, Gasior Z, Szymanski L, Loboz-Grudzien K, Jaroch J, Nowalany-Kozielska E, Glanowska G, Ziaja K, Bolkowski T, Napora P, Molski S, Molski M, Staszkiewicz W, Slowinski P, Krzeminska-Pakula M, Bednarkiewicz Z, Gruszka A, Gruszka A, Fiszer U, Palasik W, Kornacewicz-Jach Z, Wojtarowicz A, Ponikowski P, Szajn G, Domzal-Stryga A, Domzal-Stryga A, Nowak M, Nowak M, Dabrowski M, Szybka W, Opolski G, Roik M, Rynkiewicz A, Sobiczewski W, Czlonkowska A, Blazejewska-Hyzorek B, Kawecka-Jaszcz K, Bryniarski L, Chmielak Z, Kadziela J, Pasierski T, Ramotowski B, Psuja P, Wroblewski D, Mirek-Bryniarska E, Koralewska A, Szczudlik A, Zwolinska G, Oszkinis G, Snoch M, Zaleski P, Stachnio U, Milnerowicz A, Morais J, Morais J, Calé Â, Almeida P, Lopes R, dos Santos JN, Vale M, Marques AL, Gomes P, Salgado V, Cardoso H, Canhão P, Escrivanes M, Cunha L, Barreto D, Vazquez-Tanus JB 1st, Laboy N, Rodriguez-Ospina LF, Pedrosa C, Banchs HL, Pintado M, Colon-Hernandez P, Vazquez N, Ufret R, Diaz V, Garcia-Rinaldi R, Quinones S, Bragin-Sanchez DE, Fradera L, Zayas Torres CR, Negron H, Wong AS, Chua J, Dalby A, Dalby A, Allman J, Blomerus P, Erasmus L, Mabin T, Stemmett J, Mohamed Z, Solomons D, Essop M, Nunkoo T, Basson M, Terblanche M, Da Silva A, Tau T, Burgess L, Laubscher P, Ebrahim I, Bobak C, Van Zyl L, Ellis T, Corbett C, Fouche L, Ranjith N, Murally A, Retief C, Barnard W, Saaiman J, Swart Y, Roux P, Du Toit E, Manga P, Schultz O, Blignaut S, Snyman J, Roodt A, Coetsee E, Soma P, Jooste E, Sarvan M, Govender P, Gardiner J, Pearson J, Adler D, Trickett C, Steingo L, Boggett L, Horak A, Henley L, Mynhardt J, Elliott S, Bayat J, Bedhram M, Guerra M, Kuhn A, Freeman V, Johnson W, Zambakides C, Archer V, Betriu A, Heras M, de Mingo E, Jiménez Navarro M, Isasti G, Díez Tejedor E, Pérez Guevara M, Egido J, Simal P, Del Rio Ligorit A, Ferreira F, Gamero M, Geniz Clavijo M, Alonso García M, Salcedo I, Iglesias Cubero G, Villa E, Ridocci F, Ridocci F, Galve E, Nieto E, Salvador A, Rueda D, Alonso de Leciñana M, Alonso de Leciñana M, Sogorb F, Arrarte Esteban V, Puras Mallagray E, Gutierrez Baz M, Lekuona Goya I, Alarcón J, Revilla A, Mota P, Fernández-Vázquez F, Larrodé O, Bruguera Cortada J, Cabero Cereto P, Worner F, Barta L, Marín Araez E, Ramos Sánchez M, Pedreira Perez M, Moure M, San José J, Gutiérrez J, Gállego J, Ajuria I, Balaguer J, Arroyo R, Tembl J, Tembl J, Alvarez J, Ortega G, López García V, Barquero R, Roquer J, Llop M, Ruiz Salmerón R, Geniz Clavijo M, Campuzano Ruiz R, Campuzano Ruiz R, Kulisevsky J, Campolongo A, Pons J, Pons J, Segura Martin T, Ayo Martín O, Mostacero E, Pérez C, Aladro Benito Y, Escolar E, Fernandez-Bolaños R, Ossorno P, Casado Naranjo I, Portilla Cuenca J, Gil Nuñez A, García Pastor A, Marti Vilalta J, Marin R, Millan M, Reverte S, Garcia-Moll X, Garcia-Moll X, Terns M, Dachs M, Dellborg M, Dellborg M, Svensson H, Cederin B, Elgåsen A, Jonasson T, Brock A, Lindblad B, Karlsson J, Sundqvist Y, Tyden P, Stensgaard E, Erlinge D, Wagner H, Håkansson Å, Svensson P, Andersson I, Jernberg T, Berglund M, Mooe T, Carlsson B, Bandh S, Andersson C, Wahlgren CM, Johansson M, Lund L, Lidin M, Hellberg A, Falldén-Gunnnarsson A, Konrad P, Jarl L, Tygesen H, Bergsten J, Christensen K, Johansson K, Samad B, Löf P, Lannemyr O, Magyarovari I, Persson B, Moodh J, Welin L, Pettersson U, Ercegovac V, Wedeen G, Engström A, Bjurling E, Wahlgren N, Wahlgren N, Gottsäter A, Eriksson M, Blom KB, Andersson R, Bounameaux H, Amann-Vesti B, Gitzelmann-Saxer G, Banyai M, Probst E, Baumgartner-Peuker I, Zinger T, Beer H, Hischier D, Krapf R, Kofmel A, Bounameaux H, Spycher R, Cerny A, Fossati E, Eberli F, Frey C, Frank U, Frank U, Genné D, Kundig F, Gröchenig E, Sidler L, Jäger K, Widmer S, Moccetti T, Rossi M, Mueller C, Haaf P, Pieper M, Weber K, Rickli H, Schefer M, Mazzolai L, Jaltier A, Michel M, D'Ambrogio S, Gallino A, Moccetti M, Wilcox R, Levy T, Lakeman N, Squire I, Parker E, Brady A, McAdam M, de Belder M, Atkinson B, Penny W, Davies L, Bellenger N, Renouf A, Mcintyre H, Bacon S, Dutka D, Pugh J, Davies J, Covell W, Gorog D, Gregory T, Khattar R, Maciver K, Ahsan A, Burton J, Sulke N, Large J, Pye M, Hairsine B, Cohen A, Wilmott R, Riddell J, Hunter B, Spratt J, Taylor F, Been M, De Burca B, Roberts D, Helliwell L, Soo L, Arbenser E, O Rourke B, Young J, Pell A, Anderson J, Oldroyd K, Fraser D, Senior R, Young G, Keeling P, Hughes D, Scott D, Dewhirst N, Brittenden J, Herd V, Rowlands D, Hamill S, Rees A, Jones L, MacLeod M, McGhee C, Krishnamoorthy S, Cochrane H, Prakash K, Swart E, Jenkinson D, Orpen A, Henriksen P, Rif B, Sprigings D, O' Callaghan J, Manoharan G, McAllister P, Kaski J, Brown S, Storey R, Steele H, Calvert J, Brodie K, Tindall H, Serghides H, Manoj A, Ledger A, Bamford J, Bellfield R, Bath P, Cox P, Connor M, McCormick K, Connolly D, Lambley-Burke R, Rowley J, Aldred J, Qureshi N, Nolt J, Morrow D, Scirica B, Bank A, LaRock J, Aggarwal K, Lau-Sieckman A, Ashraf R, Frew S, Atassi K, Christy L, Aycock GR, Tatum D, Lafferty J, Acevedo L, Bertolet B, McDuffie D, Broadwater SR, Edwards M, Carr K, Peek M, Chandler AB Jr, Hansen J, Chandrashekhar Y, Tetrick L, Cohen M, Strout B, Comerota A, Shuman S, Vicari RM, Jordan J, Corbelli JC, Galla A, Weiss RJ, Crawford M, Wohns D, Anderson J, Singh V, Marlow L, Bresee SB, Alexander J, Stella J, Garvey ML, Suresh DP, Cook V, Tilkian A, Parker S, Unks DM, Blakely J, Rogers W, Saag L, Blonder RD, Graf E, Roth EM, Baumann M, Saenz C, Stastny C, Saucedo J, Clark J, Seigel P, Riofrio KD, deLemos J, Kelly C, Peart B, Peart K, Pollock S, Johnson S, Harris JS, Abell T, Puri S, Antonio-Drabek C, Qureshi MA, Marentette C, Ramachandran A, Kelso K, Rezkalla S, Johnson M, Ring M, Barnett S, Minisi A, Jeter D, Lee K, Strootman D, Tadros G, Antolick A, Nadar V, Darrow KA, Drenning D, Lamb B, Nash S, Wallace H, D'Urso M, Southam D, Niederman A, Vujanic S, Eaton GM, Looney A, Denning SM, Cuenot N, French W, Barillas O, Gelormini J, Hejna E, Gilmore R, Bruney C, Lopez M, Schenks R, Goodman MA, Cappelli J, Mahmud E, Judd C, Gordon P, Desimone L, Gupta D, Trussell C, McGuinn WP 2nd, Walton A, Hakas JF Jr, Horne W, McLaurin BT, Davis C, Hamroff GS, Hollenweger L, Harris JO, Scott M, Khan N, Sutton B, Henderson D, Crandall L, Langer M, Mack M, Hermany P, Dengler S, Jan M, Warrener C, Jones S, Stover T, Kase C, Lau H, Kereiakes DJ, Francis K, Kim E, Rasmussen H, Kleiman N, Hernandez E, Korban E, Manns D, Clark W, Foley J, Prashad R, McDonough C, House KW, Hobbs-Williams J, Mayer TA, Genova E, Lui HK, Holman L, Ravi RC, Diederick M, Hughes R, Applegate M, Cucher FH, Gerrish S, Anderson JL, Kirkhuff B, Pacheco T, Kuchenrither C, Josephson R, Warnick K, Doty WD, Parsons T, Vlastaris A, Bittel B, Ziada K, Oremus R, Moles EK, Mugmon MA, Latteri J, Nygaard T, White J, Thomas JC, Tetrault AL, Campbell WB, Dekoff N, Chilakamarri V, Park T, Hodson R, Payne C, DelCore M, Butkus E, Lewis D, Jacobson D, Helmy T, Werner C, Gurbel P, Gesheff T, McCullum K, Delio-Cox B, Chaturvedi S, Mada F, Shaikh SR, Shepler A, Moursi M, Brock S, Ledbetter L, Royse H, Quartner J, Downing J, Haddad TM, Overbeck D, Langer MM, Fritsch J, Drossner MN, Simmons T, Katzan I, Turczyk J, Oliver T, Lapsansky J, Goldstein MA, Lutz H, Yousuf KA, Downing J, Nash MN, Previto L, Levin K, Warnock L, Alberts MJ, Muskovich K, Sotolongo C, Domingo D, Ford A, Serna J, Chandna H, Holly D, Labroo A, Lopez C, Carlini WG, Jaasko K, Picone MF, Musick P, Vora KN, Hillard T, Varma SK, Collins S, Kuvin JT, Mooney P, Porterfield J, Lutz H, Katopodis J, Knap P, Madison J, Morgan J, Cochran D, Swafford S, Lloyd BF, Lehmann J, Wiseman A, Whited C, Muhlestein JB, Johnson E, Hack T, Sullivan SL, Mehta RH, Watkins K, Lee-Kwen P, McGowan P, Pratt R, Neeper L, Gencheff NE, Nease J, Felten W, Braem J, Perlmutter N, Rees J, Das D, Byrd J, Abrahams L, Leone C, Chen C, Gilbert C, Banish DH, Nicely VL, Chokshi S, Holbrook V, Misra V, Brott B, Harshberger J, Horwitz P, Wilson RK, Bacharach JM, Farley R, Verro P, Lim S, Peterson JG, Pape G, Bach R, Palazzolo M, Cooper MD, Lord S, Lim M, Weber E, Koch S, Lichtenberger M, Felten W, Prior J, Carlson TA, Musick P, Cashion WR Jr, Cherry R, Minor ST, Shipwash T, MacDonald L, Derbyshire S, Kraft P, Tessmar C, Fraizer M, French D, Leimbach W, Durham J, Fintel D, Davis S, Chippendale TJ, Soto E, Jacoby D, Donovan SE, Haskel EJ, Powell J, Shirwany A, Wilson J, Cole JF, Fisher M, Bayron CJ, Kochounian C, Wiviott S, Williams L, Kasner SE, DeSanto ML, Altafullah I, Lemm J, Rabiee H, Shirley T, Iteld BJ, Dureau D, Concha M, Martinez E, Teklinski A, Shaw C, Bradley AJ 3rd, Terry PS, Rashid J, Pierson M, Silliman S, Stegmaier M, Lee T, Burton C, Dietrich DW, Schaefer V, Madison JD, MacDonald H, Kmetzo J, Pierce K, Ostfeld R, Rosal-Greif V, Chaudhuri P, Kelley M, Adams K, Lohman J, Schrank J, Ebreo N, Brooks RB, Sadekoski C, Kozlowski J, Kozlowski R, Tietjen G, Korsnack A, Clark W, Foley J, Albirini A, Moore A, Holt W, Leone C, Goldberg RK, Barrett M, Gips SJ, Davis M, Fertels S, Jeffers H, Gelernt M, Vogt T, Baron S, Gros C, Koren MJ, Givens L, Gupta A, Seaton D, Staniloae CS, Liu MH, Howell GJ, Howell ST, Thadani U, Alexander D, Reyes P, Black L, Sharma MK, Gibson T, Libman R, DeMers C, Ebrahimi R, Mirshkarlo HB, Ellis J, Mooney J, Gomez CR, Lewis A, Bilazarian S, Langone L, Lowenkopf T, Rodriguez M, Abadier R, Gray L, Desai V, Myers C, Altschuller A, Oliveira KS, Patel P, Fini G, Bhagwat R, Winterrowd D, Chu AA, Edwards N, Wilson WW 3rd, Needham J, Lieberman S, Crump J, Perez JA, Addington J, Adams HP Jr, Sieren J, Katz R, Marshall L, Stein MJ, Dagher E, O'Dea DJ, Landi T, McKay R, Cloutier J, Hinchman DA, Ross J, Sanderson JN, Addington J, House K, Schidemantle E, H'Doubler P, Barnes C, Rohrbeck S, Howard A, Odhav A, Schmitz N, Schneck MJ, Chadwick LR, Sewing P, Portelli J 3rd, Landi T, Mansouri V, Duncan R, Osborne J, Gonzalez M, Gillespie EL, Rhoades S, Zweifler RM, Spady MA, Whitney R, Gocke B, Angirekula M, Bridges D, Reen BM, Marshall E, Saba F, Dunaway B, Berlowitz M, Nuce R, Whitaker J, Brooks J, Kumkumian G, Murphy M, Brown CS, Smith MA, Mostel E, Harris R, Camp A, Sheets L, Steinhoff J, Renaud K, Mayer NJ, Escallier K, Tang A, Green C, Taheri H, Morgan K, Galloway J, Dauer M, Arthur A, Hogan C, Kozak M, Jefferson D, Carter E, Moore R, Isserman SM, Moore C, Kersh RI, DaCosta A, Frey A, Short L, Stein B, McGee R, Schneider D, Chadwick L, Puleo P, Tarsi D, Singh N, Logwood D.

Author information

  • 1Thrombolysis in Myocardial Infarction (TIMI) Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. dmorrow@partners.org

Abstract

BACKGROUND:

Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1.

METHODS:

We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage.

RESULTS:

At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P<0.001). Cardiovascular death, myocardial infarction, stroke, or recurrent ischemia leading to revascularization occurred in 1259 patients (11.2%) in the vorapaxar group and 1417 patients (12.4%) in the placebo group (hazard ratio, 0.88; 95% CI, 0.82 to 0.95; P=0.001). Moderate or severe bleeding occurred in 4.2% of patients who received vorapaxar and 2.5% of those who received placebo (hazard ratio, 1.66; 95% CI, 1.43 to 1.93; P<0.001). There was an increase in the rate of intracranial hemorrhage in the vorapaxar group (1.0%, vs. 0.5% in the placebo group; P<0.001).

CONCLUSIONS:

Inhibition of PAR-1 with vorapaxar reduced the risk of cardiovascular death or ischemic events in patients with stable atherosclerosis who were receiving standard therapy. However, it increased the risk of moderate or severe bleeding, including intracranial hemorrhage. (Funded by Merck; TRA 2P-TIMI 50 ClinicalTrials.gov number, NCT00526474.).

Comment in

PMID:
22443427
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon
    Loading ...
    Write to the Help Desk