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Results: 13

1.

Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery - the GSK experience.

Vanderwall DE, Yuen N, Al-Ansari M, Bailey J, Fram D, Green DV, Pickett S, Vitulli G, Luengo JI, Almenoff JS.

Drug Discov Today. 2011 Aug;16(15-16):646-53. doi: 10.1016/j.drudis.2011.05.001. Epub 2011 May 11.

PMID:
21601652
2.

Disclosing ambiguous gene aliases by automatic literature profiling.

Coimbra RS, Vanderwall DE, Oliveira GC.

BMC Genomics. 2010 Dec 22;11 Suppl 5:S3. doi: 10.1186/1471-2164-11-S5-S3.

3.

Thousands of chemical starting points for antimalarial lead identification.

Gamo FJ, Sanz LM, Vidal J, de Cozar C, Alvarez E, Lavandera JL, Vanderwall DE, Green DV, Kumar V, Hasan S, Brown JR, Peishoff CE, Cardon LR, Garcia-Bustos JF.

Nature. 2010 May 20;465(7296):305-10. doi: 10.1038/nature09107.

PMID:
20485427
4.

Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.

Rheault TR, Caferro TR, Dickerson SH, Donaldson KH, Gaul MD, Goetz AS, Mullin RJ, McDonald OB, Petrov KG, Rusnak DW, Shewchuk LM, Spehar GM, Truesdale AT, Vanderwall DE, Wood ER, Uehling DE.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):817-20. doi: 10.1016/j.bmcl.2008.12.011. Epub 2008 Dec 7.

PMID:
19111461
5.

6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.

Wood ER, Shewchuk LM, Ellis B, Brignola P, Brashear RL, Caferro TR, Dickerson SH, Dickson HD, Donaldson KH, Gaul M, Griffin RJ, Hassell AM, Keith B, Mullin R, Petrov KG, Reno MJ, Rusnak DW, Tadepalli SM, Ulrich JC, Wagner CD, Vanderwall DE, Waterson AG, Williams JD, White WL, Uehling DE.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2773-8. doi: 10.1073/pnas.0708281105. Epub 2008 Feb 19. Erratum in: Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6208.

6.

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

Xu RX, Rocque WJ, Lambert MH, Vanderwall DE, Luther MA, Nolte RT.

J Mol Biol. 2004 Mar 19;337(2):355-65.

PMID:
15003452
7.

Correlation between in vitro peptide binding profiles and cellular activities for estrogen receptor-modulating compounds.

Iannone MA, Simmons CA, Kadwell SH, Svoboda DL, Vanderwall DE, Deng SJ, Consler TG, Shearin J, Gray JG, Pearce KH.

Mol Endocrinol. 2004 May;18(5):1064-81. Epub 2004 Feb 19.

PMID:
14976226
8.

Solution structure of the hydroperoxide of Co(III) phleomycin complexed with d(CCAGGCCTGG)2: evidence for binding by partial intercalation.

Wu W, Vanderwall DE, Turner CJ, Hoehn S, Chen J, Kozarich JW, Stubbe J.

Nucleic Acids Res. 2002 Nov 15;30(22):4881-91.

9.

Inhibitors of dihydrodipicolinate reductase, a key enzyme of the diaminopimelate pathway of Mycobacterium tuberculosis.

Paiva AM, Vanderwall DE, Blanchard JS, Kozarich JW, Williamson JM, Kelly TM.

Biochim Biophys Acta. 2001 Feb 9;1545(1-2):67-77.

PMID:
11342032
10.

Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.

Toney JH, Cleary KA, Hammond GG, Yuan X, May WJ, Hutchins SM, Ashton WT, Vanderwall DE.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2741-6.

PMID:
10509927
11.

Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase.

Toney JH, Fitzgerald PM, Grover-Sharma N, Olson SH, May WJ, Sundelof JG, Vanderwall DE, Cleary KA, Grant SK, Wu JK, Kozarich JW, Pompliano DL, Hammond GG.

Chem Biol. 1998 Apr;5(4):185-96.

12.
13.

Sequence-specific isotope effects on the cleavage of DNA by bleomycin.

Kozarich JW, Worth L Jr, Frank BL, Christner DF, Vanderwall DE, Stubbe J.

Science. 1989 Sep 22;245(4924):1396-9.

PMID:
2476851
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