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Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain.

Solberg NO, Chamberlin R, Vigil JR, Deck LM, Heidrich JE, Brown DC, Brady CI, Vander Jagt TA, Garwood M, Bisoffi M, Severns V, Vander Jagt DL, Sillerud LO.

J Alzheimers Dis. 2014;40(1):191-212. doi: 10.3233/JAD-131031.


Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.

Dutta P, Le A, Vander Jagt DL, Tsukamoto T, Martinez GV, Dang CV, Gillies RJ.

Cancer Res. 2013 Jul 15;73(14):4190-5. doi: 10.1158/0008-5472.CAN-13-0465. Epub 2013 May 30.


SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AβPP/PS-1 transgenic mouse brain.

Sillerud LO, Solberg NO, Chamberlain R, Orlando RA, Heidrich JE, Brown DC, Brady CI, Vander Jagt TA, Garwood M, Vander Jagt DL.

J Alzheimers Dis. 2013;34(2):349-65. doi: 10.3233/JAD-121171.


Plasma metabolomic profiles in different stages of CKD.

Shah VO, Townsend RR, Feldman HI, Pappan KL, Kensicki E, Vander Jagt DL.

Clin J Am Soc Nephrol. 2013 Mar;8(3):363-70. doi: 10.2215/CJN.05540512. Epub 2012 Dec 6.


A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization.

Orlando RA, Gonzales AM, Royer RE, Deck LM, Vander Jagt DL.

PLoS One. 2012;7(3):e31869. doi: 10.1371/journal.pone.0031869. Epub 2012 Mar 19.


Synthesis of benzyl substituted naphthalenes from benzylidene tetralones.

Deck LM, Mgani Q, Martinez A, Martinic A, Whalen LJ, Vander Jagt DL, Royer RE.

Tetrahedron Lett. 2012 Jan 25;53(4):373-376.


The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.

Fajardo AM, MacKenzie DA, Ji M, Deck LM, Vander Jagt DL, Thompson TA, Bisoffi M.

Prostate. 2012 May 1;72(6):612-25. doi: 10.1002/pros.21464. Epub 2011 Jul 27.


Synthesis of Hemigossypol and its Derivatives.

Wei J, Vander Jagt DL, Royer RE, Deck LM.

Tetrahedron Lett. 2010 Oct 3;51(44):5757-5760. Epub 2010 Aug 30.


Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.

Shah VO, Ferguson JE, Hunsaker LA, Deck LM, Vander Jagt DL.

Nat Prod Res. 2010 Jul;24(12):1177-88. doi: 10.1080/14786410903112680.


Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.

Orlando RA, Gonzales AM, Hunsaker LA, Franco CR, Royer RE, Vander Jagt DL, Vander Jagt DJ.

J Med Food. 2010 Aug;13(4):888-95. doi: 10.1089/jmf.2009.1128.


Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.

Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. doi: 10.1073/pnas.0914433107. Epub 2010 Jan 19.


Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.

Deck LM, Hunsaker LA, Gonzales AM, Orlando RA, Vander Jagt DL.

BMC Pharmacol. 2008 Nov 10;8:19. doi: 10.1186/1471-2210-8-19.


Efficient calculation of molecular properties from simulation using kernel molecular dynamics.

Brown WM, Sasson A, Bellew DR, Hunsaker LA, Martin S, Leitao A, Deck LM, Vander Jagt DL, Oprea TI.

J Chem Inf Model. 2008 Aug;48(8):1626-37. doi: 10.1021/ci8001233. Epub 2008 Aug 2.


Methylglyoxal, diabetes mellitus and diabetic complications.

Vander Jagt DL.

Drug Metabol Drug Interact. 2008;23(1-2):93-124. Review.


Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project.

Degaffe GH, Vander Jagt DL, Bobelu A, Bobelu J, Neha D, Waikaniwa M, Zager P, Shah VO.

J Diabetes Complications. 2008 Jul-Aug;22(4):267-72. doi: 10.1016/j.jdiacomp.2007.06.010. Epub 2008 Apr 16.


Isocoumarin-based inhibitors of pancreatic cholesterol esterase.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2008 May 1;16(9):5285-94. doi: 10.1016/j.bmc.2008.03.016. Epub 2008 Mar 6.


TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.

Weber WM, Hunsaker LA, Gonzales AM, Heynekamp JJ, Orlando RA, Deck LM, Vander Jagt DL.

Biochem Pharmacol. 2006 Oct 16;72(8):928-40. Epub 2006 Aug 28.


Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Deck LM, Vander Jagt DL.

BMC Chem Biol. 2006 Feb 8;6:1.


Activation of NFkappaB is inhibited by curcumin and related enones.

Weber WM, Hunsaker LA, Roybal CN, Bobrovnikova-Marjon EV, Abcouwer SF, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7.


Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression.

Roybal CN, Marmorstein LY, Vander Jagt DL, Abcouwer SF.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3973-9.

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